Lewis K - Search Results

1

Gram-scale total synthesis of teixobactin promoting binding mode study and discovery of more potent antibiotics.

Zong Y, Fang F, Meyer KJ, Wang L, Ni Z, Gao H, Lewis K, Zhang J, Rao Y. Zong Y, et al. Among authors: lewis k. Nat Commun. 2019 Jul 22;10(1):3268. doi: 10.1038/s41467-019-11211-y. Nat Commun. 2019. PMID: 31332172 Free PMC article.

2

Antibiotics: Recover the lost art of drug discovery.

Lewis K. Lewis K. Nature. 2012 May 23;485(7399):439-40. doi: 10.1038/485439a. Nature. 2012. PMID: 22622552 No abstract available.

3

Activated ClpP kills persisters and eradicates a chronic biofilm infection.

Conlon BP, Nakayasu ES, Fleck LE, LaFleur MD, Isabella VM, Coleman K, Leonard SN, Smith RD, Adkins JN, Lewis K. Conlon BP, et al. Among authors: lewis k. Nature. 2013 Nov 21;503(7476):365-70. doi: 10.1038/nature12790. Epub 2013 Nov 13. Nature. 2013. PMID: 24226776 Free PMC article.

4

A new antibiotic kills pathogens without detectable resistance.

Ling LL, Schneider T, Peoples AJ, Spoering AL, Engels I, Conlon BP, Mueller A, Schäberle TF, Hughes DE, Epstein S, Jones M, Lazarides L, Steadman VA, Cohen DR, Felix CR, Fetterman KA, Millett WP, Nitti AG, Zullo AM, Chen C, Lewis K. Ling LL, et al. Among authors: lewis k. Nature. 2015 Jan 22;517(7535):455-9. doi: 10.1038/nature14098. Epub 2015 Jan 7. Nature. 2015. PMID: 25561178 Free PMC article.

5

HipBA-promoter structures reveal the basis of heritable multidrug tolerance.

Schumacher MA, Balani P, Min J, Chinnam NB, Hansen S, Vulić M, Lewis K, Brennan RG. Schumacher MA, et al. Among authors: lewis k. Nature. 2015 Aug 6;524(7563):59-64. doi: 10.1038/nature14662. Epub 2015 Jul 29. Nature. 2015. PMID: 26222023 Free PMC article.

6

Microbiology: Antibiotics right under our nose.

Lewis K, Strandwitz P. Lewis K, et al. Nature. 2016 Jul 28;535(7613):501-2. doi: 10.1038/535501a. Nature. 2016. PMID: 27466121 No abstract available.

7

Dual Targeting of Cell Wall Precursors by Teixobactin Leads to Cell Lysis.

Homma T, Nuxoll A, Gandt AB, Ebner P, Engels I, Schneider T, Götz F, Lewis K, Conlon BP. Homma T, et al. Among authors: lewis k. Antimicrob Agents Chemother. 2016 Oct 21;60(11):6510-6517. doi: 10.1128/AAC.01050-16. Print 2016 Nov. Antimicrob Agents Chemother. 2016. PMID: 27550357 Free PMC article.

8

Persister formation in Staphylococcus aureus is associated with ATP depletion.

Conlon BP, Rowe SE, Gandt AB, Nuxoll AS, Donegan NP, Zalis EA, Clair G, Adkins JN, Cheung AL, Lewis K. Conlon BP, et al. Among authors: lewis k. Nat Microbiol. 2016 Apr 18;1:16051. doi: 10.1038/nmicrobiol.2016.51. Nat Microbiol. 2016. PMID: 27572649

9

Reducing the Bottleneck in Discovery of Novel Antibiotics.

Jones MB, Nierman WC, Shan Y, Frank BC, Spoering A, Ling L, Peoples A, Zullo A, Lewis K, Nelson KE. Jones MB, et al. Among authors: lewis k. Microb Ecol. 2017 Apr;73(3):658-667. doi: 10.1007/s00248-016-0889-3. Epub 2016 Nov 28. Microb Ecol. 2017. PMID: 27896376

10

Developing Equipotent Teixobactin Analogues against Drug-Resistant Bacteria and Discovering a Hydrophobic Interaction between Lipid II and Teixobactin.

Zong Y, Sun X, Gao H, Meyer KJ, Lewis K, Rao Y. Zong Y, et al. Among authors: lewis k. J Med Chem. 2018 Apr 26;61(8):3409-3421. doi: 10.1021/acs.jmedchem.7b01241. Epub 2018 Apr 13. J Med Chem. 2018. PMID: 29629769

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