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320 results

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Page 1
LGALS3BP in Microglia Promotes Retinal Angiogenesis Through PI3K/AKT Pathway During Hypoxia.
Zhao C, Liu Y, Meng J, Wang X, Liu X, Li W, Zhou Q, Xiang J, Li N, Hou S. Zhao C, et al. Invest Ophthalmol Vis Sci. 2022 Jul 8;63(8):25. doi: 10.1167/iovs.63.8.25. Invest Ophthalmol Vis Sci. 2022. PMID: 35895036 Free PMC article.
METHODS: The expression of LGALS3BP in microglia was detected by immunofluorescence, RT-qPCR, and western blotting. ...CONCLUSIONS: Collectively, our findings suggest that LGALS3BP in microglia plays an important role in angiogenesis, suggesting a potential therapeu …
METHODS: The expression of LGALS3BP in microglia was detected by immunofluorescence, RT-qPCR, and western blotting. ...CONCLUSIONS: C …
Extracellular LGALS3BP: a potential disease marker and actionable target for antibody-drug conjugate therapy in glioblastoma.
Dufrusine B, Capone E, Ponziani S, Lattanzio R, Lanuti P, Giansanti F, De Laurenzi V, Iacobelli S, Ippoliti R, Mangiola A, Trevisi G, Sala G. Dufrusine B, et al. Mol Oncol. 2023 Aug;17(8):1460-1473. doi: 10.1002/1878-0261.13453. Epub 2023 Jun 7. Mol Oncol. 2023. PMID: 37195369 Free PMC article.
Moreover, analysis of plasma-derived extracellular vesicles from mice harbouring human GBM revealed that LGALS3BP can be used for liquid biopsy as a marker of disease. Finally, an ADC targeting LGALS3BP, named 1959-sss/DM4, specifically accumulates in tumour tissue, …
Moreover, analysis of plasma-derived extracellular vesicles from mice harbouring human GBM revealed that LGALS3BP can be used for liq …
LGALS3BP is a potential target of antibody-drug conjugates in oral squamous cell carcinoma.
Cela I, Caponio VCA, Capone E, Pinti M, Mascitti M, Togni L, Lo Muzio L, Rubini C, De Laurenzi V, Lattanzio R, Perrotti V, Sala G. Cela I, et al. Oral Dis. 2023 Aug 31. doi: 10.1111/odi.14719. Online ahead of print. Oral Dis. 2023. PMID: 37649401
RESULTS: LGALS3BP resulted in being highly expressed in the cytoplasm of tumour cells in OSCC patient tissues. A strong correlation was found between high LGALS3BP expression levels and aggressive histological features of OSCC. ...
RESULTS: LGALS3BP resulted in being highly expressed in the cytoplasm of tumour cells in OSCC patient tissues. A strong correlation w …
90K/LGALS3BP expression is upregulated in COVID-19 but may not restrict SARS-CoV-2 infection.
Bosquillon de Jarcy L, Akbil B, Mhlekude B, Leyens J, Postmus D, Harnisch G, Jansen J, Schmidt ML, Aigner A, Pott F, Chua RL, Krist L, Gentile R, Mühlemann B, Jones TC, Niemeyer D, Fricke J, Keil T, Pischon T, Janke J, Conrad C, Iacobelli S, Drosten C, Corman VM, Ralser M, Eils R, Kurth F, Sander L, Goffinet C. Bosquillon de Jarcy L, et al. Clin Exp Med. 2023 Nov;23(7):3689-3700. doi: 10.1007/s10238-023-01077-2. Epub 2023 May 10. Clin Exp Med. 2023. PMID: 37162650 Free PMC article.
Its antiviral potential in SARS-CoV-2 infection remains largely unknown. Here, we analyzed the expression of 90K/LGALS3BP in 44 hospitalized COVID-19 patients at multiple levels. We quantified 90K protein concentrations in serum and PBMCs as well as LGALS3BP mRNA le …
Its antiviral potential in SARS-CoV-2 infection remains largely unknown. Here, we analyzed the expression of 90K/LGALS3BP in 44 hospi …
Extracellular LGALS3BP regulates neural progenitor position and relates to human cortical complexity.
Kyrousi C, O'Neill AC, Brazovskaja A, He Z, Kielkowski P, Coquand L, Di Giaimo R, D' Andrea P, Belka A, Forero Echeverry A, Mei D, Lenge M, Cruceanu C, Buchsbaum IY, Khattak S, Fabien G, Binder E, Elmslie F, Guerrini R, Baffet AD, Sieber SA, Treutlein B, Robertson SP, Cappello S. Kyrousi C, et al. Nat Commun. 2021 Nov 2;12(1):6298. doi: 10.1038/s41467-021-26447-w. Nat Commun. 2021. PMID: 34728600 Free PMC article.
We show that individuals with LGALS3BP de novo variants exhibit altered local gyrification, sulcal depth, surface area and thickness in their cortex. Additionally, using cerebral organoids, human fetal tissues and mice, we show that LGALS3BP regulates the position o …
We show that individuals with LGALS3BP de novo variants exhibit altered local gyrification, sulcal depth, surface area and thickness …
Platelet LGALS3BP as a Mediator of Myeloid Inflammation in Systemic Lupus Erythematosus.
El Bannoudi H, Cornwell M, Luttrell-Williams E, Engel A, Rolling C, Barrett TJ, Izmirly P, Belmont HM, Ruggles K, Clancy R, Buyon J, Berger JS. El Bannoudi H, et al. Arthritis Rheumatol. 2023 May;75(5):711-722. doi: 10.1002/art.42382. Epub 2023 Mar 14. Arthritis Rheumatol. 2023. PMID: 36245285

RESULTS: Platelets from patients with SLE exhibited increased expression of LGALS3BP (fold change 4.0, adjusted P = 6.02 10(-11) ). Platelet-released LGALS3BP levels were highly correlated with circulating LGALS3BP (R = 0.69, P < 0.0001), and circulating

…
RESULTS: Platelets from patients with SLE exhibited increased expression of LGALS3BP (fold change 4.0, adjusted P = 6.02 10(-11) ). P …
LGALS3BP/Gal-3 promotes osteogenic differentiation of human periodontal ligament stem cells.
Zhang L, Huang Y, Lou H, Gong X, Ouyang Q, Yu H. Zhang L, et al. Arch Oral Biol. 2021 Aug;128:105149. doi: 10.1016/j.archoralbio.2021.105149. Epub 2021 May 12. Arch Oral Biol. 2021. PMID: 34052527
METHODS: IP-WB experiments were carried out to examine the binding of LGALS3BP and Gal-3. Western blot was performed to detect the expressions of LGALS3BP and Gal-3 in hPDLSCs with or without osteogenic differentiation inducement. ...LGALS3BP also promoted os …
METHODS: IP-WB experiments were carried out to examine the binding of LGALS3BP and Gal-3. Western blot was performed to detect the ex …
The GALNT6-LGALS3BP axis promotes breast cancer cell growth.
Kimura R, Yoshimaru T, Matsushita Y, Matsuo T, Ono M, Park JH, Sasa M, Miyoshi Y, Nakamura Y, Katagiri T. Kimura R, et al. Int J Oncol. 2020 Feb;56(2):581-595. doi: 10.3892/ijo.2019.4941. Epub 2019 Dec 13. Int J Oncol. 2020. PMID: 31894262
The Cancer Genome Atlas data analysis revealed that high expression levels of GALNT6 were significantly associated with poor prognosis of breast cancer. GALNT6 O-glycosylated LGALS3BP in breast cancer cells, whereas knockdown of GALNT6 by siRNA led to the inhibition of bot …
The Cancer Genome Atlas data analysis revealed that high expression levels of GALNT6 were significantly associated with poor prognosis of br …
Lgals3bp suppresses colon inflammation and tumorigenesis through the downregulation of TAK1-NF-kappaB signaling.
Cho SH, Shim HJ, Park MR, Choi JN, Akanda MR, Hwang JE, Bae WK, Lee KH, Sun EG, Chung IJ. Cho SH, et al. Cell Death Discov. 2021 Apr 6;7(1):65. doi: 10.1038/s41420-021-00447-7. Cell Death Discov. 2021. PMID: 33824294 Free PMC article.
Mechanistically, Lgals3bp suppressed NF-kappaB through the downregulation of TAK1 in colon epithelial cells. ...Instead, Lgals3bp(-/-) mice showed elevated levels of GM-CSF, compared to those in WT mice. ...
Mechanistically, Lgals3bp suppressed NF-kappaB through the downregulation of TAK1 in colon epithelial cells. ...Instead, Lgals3bp …
Increased LGALS3BP promotes proliferation and migration of oral squamous cell carcinoma via PI3K/AKT pathway.
Zhang X, Ding H, Lu Z, Ding L, Song Y, Jing Y, Hu Q, Dong Y, Ni Y. Zhang X, et al. Cell Signal. 2019 Nov;63:109359. doi: 10.1016/j.cellsig.2019.109359. Epub 2019 Jul 11. Cell Signal. 2019. PMID: 31302247
LGALS3BP was significantly up-regulated in OSCC tumor tissues. IHC analysis showed that LGALS3BP was predominantly expressed in tumor cells and correlated with poor clinical characteristics. In addition, high LGALS3BP expression predicted poor clinical outcom …
LGALS3BP was significantly up-regulated in OSCC tumor tissues. IHC analysis showed that LGALS3BP was predominantly expressed i …
320 results