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1984 1
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2012 1
2015 2
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2020 17
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Page 1
The histidine phosphatase LHPP: an emerging player in cancer.
Wu F, Ma H, Wang X, Wei H, Zhang W, Zhang Y. Wu F, et al. Cell Cycle. 2022 Jun;21(11):1140-1152. doi: 10.1080/15384101.2022.2044148. Epub 2022 Mar 3. Cell Cycle. 2022. PMID: 35239447 Free PMC article. Review.
It has been reported in the literature that LHPP is expressed at low levels in tumor tissues and cells and that patients with low LHPP expression have a poorer prognosis. ...In addition, researchers have used iDPP nanoparticles to deliver LHPP plasmids to tre …
It has been reported in the literature that LHPP is expressed at low levels in tumor tissues and cells and that patients with low …
LHPP in Glutamatergic Neurons of the Ventral Hippocampus Mediates Depression-like Behavior by Dephosphorylating CaMKIIalpha and ERK.
Zhuang L, Gao W, Chen Y, Fang W, Lo H, Dai X, Zhang J, Chen W, Ye Q, Chen X, Zhang J. Zhuang L, et al. Biol Psychiatry. 2024 Mar 1;95(5):389-402. doi: 10.1016/j.biopsych.2023.08.026. Epub 2023 Sep 9. Biol Psychiatry. 2024. PMID: 37678540
Knockout of LHPP in glutamatergic neurons of the brain improved the spontaneous activity of LHPP(flox/flox).CaMKIIalphaCre+ (conditional knockout) mice. ...Notably, compared with wild-type LHPP, human mutant LHPP (E56K, S57L) significantly increased th …
Knockout of LHPP in glutamatergic neurons of the brain improved the spontaneous activity of LHPP(flox/flox).CaMKIIalphaCre+ (c …
Long noncoding RNA DLGAP1-AS2 promotes tumorigenesis and metastasis by regulating the Trim21/ELOA/LHPP axis in colorectal cancer.
Wang X, Cheng H, Zhao J, Li J, Chen Y, Cui K, Tian L, Zhang J, Li C, Sun S, Feng Y, Yao S, Bian Z, Huang S, Fei B, Huang Z. Wang X, et al. Mol Cancer. 2022 Nov 14;21(1):210. doi: 10.1186/s12943-022-01675-w. Mol Cancer. 2022. PMID: 36376892 Free PMC article.
In particular, we revealed that DLGAP1-AS2 decreases phospholysine phosphohistidine inorganic pyrophosphate phosphatase (LHPP) expression by inhibiting ELOA-mediated transcriptional activating of LHPP and thus blocking LHPP-dependent suppression of the AKT si …
In particular, we revealed that DLGAP1-AS2 decreases phospholysine phosphohistidine inorganic pyrophosphate phosphatase (LHPP) expres …
LHPP suppresses gastric cancer progression via the PI3K/AKT/mTOR signaling pathway.
Wang D, Li J, Li W. Wang D, et al. J Cancer. 2022 Oct 31;13(14):3584-3592. doi: 10.7150/jca.78098. eCollection 2022. J Cancer. 2022. PMID: 36484014 Free PMC article.
Emerging evidence has revealed the anti-oncogenic role of LHPP in several malignancies. The current study aims to explore the underlying mechanism of LHPP in gastric cancer (GC). ...Mechanically, LHPP overexpression led to decreased level of PI3K/AKT/mTOR pat …
Emerging evidence has revealed the anti-oncogenic role of LHPP in several malignancies. The current study aims to explore the underly …
LHPP-mediated inorganic pyrophosphate hydrolysis-driven lysosomal acidification in astrocytes regulates adult neurogenesis.
Sha L, Li J, Shen H, Wang Q, Meng P, Zhang X, Deng Y, Zhu W, Xu Q. Sha L, et al. Cell Rep. 2023 Aug 29;42(8):112975. doi: 10.1016/j.celrep.2023.112975. Epub 2023 Aug 12. Cell Rep. 2023. PMID: 37573508 Free article.
LHPP knockout (KO) mice have no discernable phenotype but are resilient to chronic-stress-induced depression-like behaviors. ...Together, these findings suggest that LHPP is likely to be a therapeutic target for stress-related brain disease....
LHPP knockout (KO) mice have no discernable phenotype but are resilient to chronic-stress-induced depression-like behaviors. ...Toget …
LHPP expression in neurons.
Lin D, Li L, Chen WB, Chen J, Ren D, Zheng ZH, Zhao C, Zhong Y, Luo B, Jing H, Chen P, Zou S, Lai X, Zhou T, Ding N, Li L, Pan BX, Fei E. Lin D, et al. Mol Psychiatry. 2023 Feb;28(2):517. doi: 10.1038/s41380-022-01923-x. Mol Psychiatry. 2023. PMID: 36755101 No abstract available.
LHPP suppresses tumorigenesis of intrahepatic cholangiocarcinoma by inhibiting the TGFbeta/smad signaling pathway.
Wang D, Ning Z, Zhu Z, Zhang C, Wang P, Meng Z. Wang D, et al. Int J Biochem Cell Biol. 2021 Mar;132:105845. doi: 10.1016/j.biocel.2020.105845. Epub 2021 Jan 2. Int J Biochem Cell Biol. 2021. PMID: 33401010
Here, we investigate the effect of LHPP in intrahepatic cholangiocarcinoma (ICC). We discovered that LHPP was downregulated in tumor tissues and low levels of LHPP predicted poor survival. ...Our results indicated that LHPP is a potential therapeutic t …
Here, we investigate the effect of LHPP in intrahepatic cholangiocarcinoma (ICC). We discovered that LHPP was downregulated in …
LHPP, a risk factor for major depressive disorder, regulates stress-induced depression-like behaviors through its histidine phosphatase activity.
Lin D, Li L, Chen WB, Chen J, Ren D, Zheng ZH, Zhao C, Zhong Y, Luo B, Jing H, Chen P, Zou S, Lai X, Zhou T, Ding N, Li L, Pan BX, Fei E. Lin D, et al. Mol Psychiatry. 2023 Feb;28(2):908-918. doi: 10.1038/s41380-022-01893-0. Epub 2022 Dec 2. Mol Psychiatry. 2023. PMID: 36460727
This augmentation could be recapitulated by the local deletion of LHPP in mPFC. By contrast, overexpressing LHPP in mPFC increased the mice's resilience against CSDS, suggesting a critical role of mPFC LHPP in stress-induced depression. ...Finally, reintroduc …
This augmentation could be recapitulated by the local deletion of LHPP in mPFC. By contrast, overexpressing LHPP in mPFC incre …
LHPP inhibits hepatocellular carcinoma cell growth and metastasis.
Liao L, Duan D, Liu Y, Chen L. Liao L, et al. Cell Cycle. 2020 Jul;19(14):1846-1854. doi: 10.1080/15384101.2020.1783472. Epub 2020 Jun 24. Cell Cycle. 2020. PMID: 32578511 Free PMC article.
In this study, we aimed to investigate the roles of Phospholysine Phosphohistidine Inorganic Pyrophosphate Phosphatase (LHPP)in human HCCcell growth and metastasis. We analyzed the LHPP expression level in human HCC tissues paired normal tissues in the Oncomine data …
In this study, we aimed to investigate the roles of Phospholysine Phosphohistidine Inorganic Pyrophosphate Phosphatase (LHPP)in human …
LHPP suppresses proliferation, migration, and invasion and promotes apoptosis in pancreatic cancer.
Wu F, Chen Y, Zhu J. Wu F, et al. Biosci Rep. 2020 Mar 27;40(3):BSR20194142. doi: 10.1042/BSR20194142. Biosci Rep. 2020. PMID: 32186702 Free PMC article.
The results showed that LHPP restrained PaCa cell proliferation, migration, and invasion. ...Moreover, LHPP-induced apoptosis was diminished by SC79 (AKT activator) in PaCa cells. ...
The results showed that LHPP restrained PaCa cell proliferation, migration, and invasion. ...Moreover, LHPP-induced apoptosis …
100 results