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In vitro human hepatocyte-based experimental systems for the evaluation of human drug metabolism, drug-drug interactions, and drug toxicity in drug development.
Li AP. Li AP. Curr Top Med Chem. 2014;14(11):1325-38. doi: 10.2174/1568026614666140506114411. Curr Top Med Chem. 2014. PMID: 24805059 Review.
Applications of primary human hepatocytes in the evaluation of pharmacokinetic drug-drug interactions: evaluation of model drugs terfenadine and rifampin.
Li AP, Jurima-Romet M. Li AP, et al. Cell Biol Toxicol. 1997 Jul;13(4-5):365-74. doi: 10.1023/a:1007451911843. Cell Biol Toxicol. 1997. PMID: 9298257
Overview: pharmacokinetic drug-drug interactions.
Li AP, Jurima-Romet M. Li AP, et al. Adv Pharmacol. 1997;43:1-6. doi: 10.1016/s1054-3589(08)60199-4. Adv Pharmacol. 1997. PMID: 9342170 Review. No abstract available.
Primary hepatocyte cultures as an in vitro experimental model for the evaluation of pharmacokinetic drug-drug interactions.
Li AP. Li AP. Adv Pharmacol. 1997;43:103-30. doi: 10.1016/s1054-3589(08)60203-3. Adv Pharmacol. 1997. PMID: 9342174 Review. No abstract available.
Preclinical evaluation of drug-drug interaction potential: present status of the application of primary human hepatocytes in the evaluation of cytochrome P450 induction.
Li AP, Maurel P, Gomez-Lechon MJ, Cheng LC, Jurima-Romet M. Li AP, et al. Chem Biol Interact. 1997 Nov 6;107(1-2):5-16. doi: 10.1016/s0009-2797(97)00070-7. Chem Biol Interact. 1997. PMID: 9402946 Review.
Primary human hepatocytes as a tool for the evaluation of structure-activity relationship in cytochrome P450 induction potential of xenobiotics: evaluation of rifampin, rifapentine and rifabutin.
Li AP, Reith MK, Rasmussen A, Gorski JC, Hall SD, Xu L, Kaminski DL, Cheng LK. Li AP, et al. Chem Biol Interact. 1997 Nov 6;107(1-2):17-30. doi: 10.1016/s0009-2797(97)00071-9. Chem Biol Interact. 1997. PMID: 9402947
Overview: hepatocytes and cryopreservation--a personal historical perspective.
Li AP. Li AP. Chem Biol Interact. 1999 Jun 1;121(1):1-5. doi: 10.1016/s0009-2797(99)00086-1. Chem Biol Interact. 1999. PMID: 10418966
Cryopreserved human hepatocytes: characterization of drug-metabolizing enzyme activities and applications in higher throughput screening assays for hepatotoxicity, metabolic stability, and drug-drug interaction potential.
Li AP, Lu C, Brent JA, Pham C, Fackett A, Ruegg CE, Silber PM. Li AP, et al. Chem Biol Interact. 1999 Jun 1;121(1):17-35. doi: 10.1016/s0009-2797(99)00088-5. Chem Biol Interact. 1999. PMID: 10418968
Present status of the application of cryopreserved hepatocytes in the evaluation of xenobiotics: consensus of an international expert panel.
Li AP, Gorycki PD, Hengstler JG, Kedderis GL, Koebe HG, Rahmani R, de Sousas G, Silva JM, Skett P. Li AP, et al. Chem Biol Interact. 1999 Jun 1;121(1):117-23. doi: 10.1016/s0009-2797(99)00081-2. Chem Biol Interact. 1999. PMID: 10418974 Review.
Screening for human ADME/Tox drug properties in drug discovery.
Li AP. Li AP. Drug Discov Today. 2001 Apr 1;6(7):357-366. doi: 10.1016/s1359-6446(01)01712-3. Drug Discov Today. 2001. PMID: 11267922
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