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A nonprostanoid EP4 receptor selective prostaglandin E2 agonist restores bone mass and strength in aged, ovariectomized rats.
Ke HZ, Crawford DT, Qi H, Simmons HA, Owen TA, Paralkar VM, Li M, Lu B, Grasser WA, Cameron KO, Lefker BA, DaSilva-Jardine P, Scott DO, Zhang Q, Tian XY, Jee WS, Brown TA, Thompson DD. Ke HZ, et al. Among authors: li m. J Bone Miner Res. 2006 Apr;21(4):565-75. doi: 10.1359/jbmr.051110. Epub 2006 Apr 5. J Bone Miner Res. 2006. PMID: 16598377 Free article.
Proline-rich tyrosine kinase 2 regulates osteoprogenitor cells and bone formation, and offers an anabolic treatment approach for osteoporosis.
Buckbinder L, Crawford DT, Qi H, Ke HZ, Olson LM, Long KR, Bonnette PC, Baumann AP, Hambor JE, Grasser WA 3rd, Pan LC, Owen TA, Luzzio MJ, Hulford CA, Gebhard DF, Paralkar VM, Simmons HA, Kath JC, Roberts WG, Smock SL, Guzman-Perez A, Brown TA, Li M. Buckbinder L, et al. Among authors: li m. Proc Natl Acad Sci U S A. 2007 Jun 19;104(25):10619-24. doi: 10.1073/pnas.0701421104. Epub 2007 May 30. Proc Natl Acad Sci U S A. 2007. PMID: 17537919 Free PMC article.
Metabolism-guided design of short-acting calcium-sensing receptor antagonists.
Southers JA, Bauman JN, Price DA, Humphries PS, Balan G, Sagal JF, Maurer TS, Zhang Y, Oliver R, Herr M, Healy DR, Li M, Kapinos B, Fate GD, Riccardi KA, Paralkar VM, Brown TA, Kalgutkar AS. Southers JA, et al. Among authors: li m. ACS Med Chem Lett. 2010 May 13;1(5):219-23. doi: 10.1021/ml100058w. eCollection 2010 Aug 12. ACS Med Chem Lett. 2010. PMID: 24900198 Free PMC article.
The discovery of novel calcium sensing receptor negative allosteric modulators.
Balan G, Bauman J, Bhattacharya S, Castrodad M, Healy DR, Herr M, Humphries P, Jennings S, Kalgutkar AS, Kapinos B, Khot V, Lazarra K, Li M, Li Y, Neagu C, Oliver R, Piotrowski DW, Price D, Qi H, Simmons HA, Southers J, Wei L, Zhang Y, Paralkar VM. Balan G, et al. Among authors: li y, li m. Bioorg Med Chem Lett. 2009 Jun 15;19(12):3328-32. doi: 10.1016/j.bmcl.2009.04.044. Epub 2009 Apr 18. Bioorg Med Chem Lett. 2009. PMID: 19442519
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