Role of substrate-product frustration on enzyme functional dynamics.
Kong J, Li J, Lu J, Li W, Wang W.
Kong J, et al. Among authors: li j, li w.
Phys Rev E. 2019 Nov;100(5-1):052409. doi: 10.1103/PhysRevE.100.052409.
Phys Rev E. 2019.
PMID: 31869999
Our recent work demonstrated that multisubstrate enzymes can utilize steric frustration encountered in the substrate-product cobound complex to overcome the bottleneck of the enzymatic cycle [W. Li et al., Phys. Rev. Lett. 122, 238102 (2019)10.1103/PhysRevLett.122.2 …
Our recent work demonstrated that multisubstrate enzymes can utilize steric frustration encountered in the substrate-product cobound complex …