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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2008 1
2009 1
2010 2
2011 1
2012 2
2013 1
2014 6
2015 4
2016 1
2018 1
2019 1
2020 2
2024 0

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23 results

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Page 1
HDAC6 mediates an aggresome-like mechanism for NLRP3 and pyrin inflammasome activation.
Magupalli VG, Negro R, Tian Y, Hauenstein AV, Di Caprio G, Skillern W, Deng Q, Orning P, Alam HB, Maliga Z, Sharif H, Hu JJ, Evavold CL, Kagan JC, Schmidt FI, Fitzgerald KA, Kirchhausen T, Li Y, Wu H. Magupalli VG, et al. Among authors: alam hb, li y. Science. 2020 Sep 18;369(6510):eaas8995. doi: 10.1126/science.aas8995. Science. 2020. PMID: 32943500 Free PMC article.
Here, we show that nucleotide-binding domain, leucine-rich repeat, and pyrin domain-containing protein 3 (NLRP3)- and pyrin-mediated inflammasome assembly, caspase activation, and IL-1beta conversion occur at the microtubule-organizing center (MTOC). Furthermore, the dynein adapt …
Here, we show that nucleotide-binding domain, leucine-rich repeat, and pyrin domain-containing protein 3 (NLRP3)- and pyrin-mediated inflamm …
Histone Deacetylase Inhibitors: A Novel Strategy in Trauma and Sepsis.
Williams AM, Dennahy IS, Bhatti UF, Biesterveld BE, Graham NJ, Li Y, Alam HB. Williams AM, et al. Among authors: alam hb, li y. Shock. 2019 Sep;52(3):300-306. doi: 10.1097/SHK.0000000000001308. Shock. 2019. PMID: 30601405 Free PMC article. Review.
Due to logistical constraints, however, definitive resuscitation with blood products is often not feasible in the prehospital setting-highlighting the importance of adjunctive therapies. In recent years, histone deacetylase inhibitors (HDACis) have shown promise as …
Due to logistical constraints, however, definitive resuscitation with blood products is often not feasible in the prehospital setting-highli …
Creating a "Prosurvival Phenotype" Through Histone Deacetylase Inhibition: Past, Present, and Future.
Halaweish I, Nikolian V, Georgoff P, Li Y, Alam HB. Halaweish I, et al. Among authors: alam hb, li y. Shock. 2015 Aug;44 Suppl 1(0 1):6-16. doi: 10.1097/SHK.0000000000000319. Shock. 2015. PMID: 25565645 Free PMC article. Review.
To date, there are no treatments with inherent prosurvival properties. Our laboratory has investigated the use of histone deacetylase inhibitors (HDACIs) as pharmacological agents to improve survival. ...Positive results have also been shown in two-hit models of hem …
To date, there are no treatments with inherent prosurvival properties. Our laboratory has investigated the use of histone deacetyl …
Histone deacetylase III as a potential therapeutic target for the treatment of lethal sepsis.
Zhao T, Li Y, Liu B, Bronson RT, Halaweish I, Alam HB. Zhao T, et al. Among authors: alam hb, li y. J Trauma Acute Care Surg. 2014 Dec;77(6):913-9; discussion 919. doi: 10.1097/TA.0000000000000347. J Trauma Acute Care Surg. 2014. PMID: 25051385 Free PMC article.
BACKGROUND: We have recently demonstrated that inhibition of histone deacetylase (HDAC) Class I, II, and IV with nonspecific HDAC inhibitors improves survival in a mouse model of lethal cecal ligation and puncture (CLP). ...The aims of the present study were to expl …
BACKGROUND: We have recently demonstrated that inhibition of histone deacetylase (HDAC) Class I, II, and IV with nonspecific H …
Modulation of acetylation: creating a pro-survival and anti-inflammatory phenotype in lethal hemorrhagic and septic shock.
Li Y, Alam HB. Li Y, et al. Among authors: alam hb. J Biomed Biotechnol. 2011;2011:523481. doi: 10.1155/2011/523481. Epub 2011 Feb 15. J Biomed Biotechnol. 2011. PMID: 21403879 Free PMC article. Review.
Histone deacetylases (HDACs) play a key role in homeostasis of protein acetylation in histone and nonhistone proteins and in regulating fundamental cellular activities. In this paper we review and discuss intriguing recent developments in the use of histon …
Histone deacetylases (HDACs) play a key role in homeostasis of protein acetylation in histone and nonhistone proteins a …
Histone deacetylase inhibitor treatment attenuates coagulation imbalance in a lethal murine model of sepsis.
Zhao T, Li Y, Liu B, Wu E, Sillesen M, Velmahos GC, Halaweish I, Alam HB. Zhao T, et al. Among authors: alam hb, li y. Surgery. 2014 Aug;156(2):214-20. doi: 10.1016/j.surg.2014.04.022. Epub 2014 Jun 21. Surgery. 2014. PMID: 24957668 Free PMC article.
BACKGROUND: Sepsis has a profound impact on the inflammatory and hemostatic systems. ...We have shown that treatment with suberoylanilide hydroxamic acid (SAHA), a histone deacetylase inhibitor (HDACI), improves survival in a lethal model of cecal ligation an …
BACKGROUND: Sepsis has a profound impact on the inflammatory and hemostatic systems. ...We have shown that treatment with suberoylani …
Selective histone deacetylase 6 inhibition prolongs survival in a lethal two-hit model.
Cheng X, Liu Z, Liu B, Zhao T, Li Y, Alam HB. Cheng X, et al. Among authors: alam hb, li y. J Surg Res. 2015 Jul;197(1):39-44. doi: 10.1016/j.jss.2015.02.070. Epub 2015 Mar 6. J Surg Res. 2015. PMID: 25837686 Free PMC article.
BACKGROUND: Hemorrhagic shock (HS) followed by a subsequent insult ("second hit") often initiates an exaggerated systemic inflammatory response and multiple organ failure. We have previously demonstrated that valproic acid, a pan histone deacetylase inhibitor, could …
BACKGROUND: Hemorrhagic shock (HS) followed by a subsequent insult ("second hit") often initiates an exaggerated systemic inflammatory respo …
Protective Effect of Tubastatin A in CLP-Induced Lethal Sepsis.
Deng Q, Zhao T, Pan B, Dennahy IS, Duan X, Williams AM, Liu B, Lin N, Bhatti UF, Chen E, Alam HB, Li Y. Deng Q, et al. Among authors: alam hb, li y. Inflammation. 2018 Dec;41(6):2101-2109. doi: 10.1007/s10753-018-0853-0. Inflammation. 2018. PMID: 30047002 Free PMC article.
We have found earlier that Tubastatin A (TubA), a selective inhibitor of histone deacetylase 6 (HDAC6), improves survival in a mouse model of lethal cecal ligation and puncture (CLP)-induced sepsis. ...Such findings may help to explain the beneficial effects …
We have found earlier that Tubastatin A (TubA), a selective inhibitor of histone deacetylase 6 (HDAC6), improves survival in a …
Histone deacetylase 6 inhibition improves survival in a swine model of lethal hemorrhage, polytrauma, and bacteremia.
Biesterveld BE, Wakam GK, Kemp MT, Williams AM, Shamshad A, O'Connell RL, Siddiqui AZ, Chtraklin K, Bhatti UF, Li Y, Alam HB. Biesterveld BE, et al. Among authors: alam hb, li y. J Trauma Acute Care Surg. 2020 Nov;89(5):932-939. doi: 10.1097/TA.0000000000002677. J Trauma Acute Care Surg. 2020. PMID: 32195993
BACKGROUND: Trauma is the leading cause of death for young Americans. Nonspecific histone deacetylase inhibitors, such as valproic acid, have been shown to improve survival in preclinical models of lethal trauma, hemorrhage, and sepsis. The doses needed to ac …
BACKGROUND: Trauma is the leading cause of death for young Americans. Nonspecific histone deacetylase inhibitors, such as valp …
Selective inhibition of histone deacetylase 6 alters the composition of circulating blood cells in a lethal septic model.
Zhao T, Li Y, Liu B, Halaweish I, Mazitschek R, Alam HB. Zhao T, et al. Among authors: alam hb, li y. J Surg Res. 2014 Aug;190(2):647-54. doi: 10.1016/j.jss.2014.01.056. Epub 2014 Feb 4. J Surg Res. 2014. PMID: 24613069 Free PMC article.
BACKGROUND: Phagocytes, especially monocytes, macrophages, and dendritic cells, play a pivotal role in the innate and adaptive immune responses during sepsis. We have shown that inhibition of histone deacetylase 6 improves survival and increases bacterial cle …
BACKGROUND: Phagocytes, especially monocytes, macrophages, and dendritic cells, play a pivotal role in the innate and adaptive immune respon …
23 results