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Pharmacological Modulation of Apoptosis and Autophagy in Pancreatic Cancer Treatment.
Selvarajoo N, Stanslas J, Islam MK, Sagineedu SR, Lian HK, Lim JCW. Selvarajoo N, et al. Mini Rev Med Chem. 2022;22(20):2581-2595. doi: 10.2174/1389557522666220324123605. Mini Rev Med Chem. 2022. PMID: 35331093 Review.
OBJECTIVE: This review compiled essential information on the regulatory mechanisms and roles of apoptosis and autophagy in pancreatic cancer, as well as drug-like molecules that target different pathways in pancreatic cancer eradication, with an aim to provide ideas to the …
OBJECTIVE: This review compiled essential information on the regulatory mechanisms and roles of apoptosis and autophagy in pancreatic cancer …
Deregulation of microRNAs in blood and skeletal muscles of myotonic dystrophy type 1 patients.
Ambrose KK, Ishak T, Lian LH, Goh KJ, Wong KT, Ahmad-Annuar A, Thong MK. Ambrose KK, et al. Neurol India. 2017 May-Jun;65(3):512-517. doi: 10.4103/neuroindia.NI_237_16. Neurol India. 2017. PMID: 28488611 Free article.
INTRODUCTION: MicroRNAs (miRNAs) are short RNA molecules of approximately 22 nucleotides that function as post-transcriptional regulators of gene expression. ...
INTRODUCTION: MicroRNAs (miRNAs) are short RNA molecules of approximately 22 nucleotides that function as post-transcriptional …
Development of Potent Type I Protein Arginine Methyltransferase (PRMT) Inhibitors of Leukemia Cell Proliferation.
Wang C, Jiang H, Jin J, Xie Y, Chen Z, Zhang H, Lian F, Liu YC, Zhang C, Ding H, Chen S, Zhang N, Zhang Y, Jiang H, Chen K, Ye F, Yao Z, Luo C. Wang C, et al. J Med Chem. 2017 Nov 9;60(21):8888-8905. doi: 10.1021/acs.jmedchem.7b01134. Epub 2017 Oct 27. J Med Chem. 2017. PMID: 29019697
Protein Arginine Methyltransferases (PRMTs) are crucial players in diverse biological processes, and dysregulation of PRMTs has been linked to various human diseases, especially cancer. Therefore, small molecules targeting PRMTs have profound impact for both academic funct …
Protein Arginine Methyltransferases (PRMTs) are crucial players in diverse biological processes, and dysregulation of PRMTs has been linked …
Study on the Rationality for Antiviral Activity of Flos Lonicerae Japonicae-Fructus Forsythiae Herb Chito-Oligosaccharide via Integral Pharmacokinetics.
Zhou W, Yin A, Shan J, Wang S, Cai B, Di L. Zhou W, et al. Molecules. 2017 Apr 20;22(4):654. doi: 10.3390/molecules22040654. Molecules. 2017. PMID: 28425933 Free PMC article.
It was found that the integral absorption, both in vitro and in vivo, especially that in Shuang-Huang-Lian, can be improved significantly by COS, an absorption enhancer based on tight junction. ...
It was found that the integral absorption, both in vitro and in vivo, especially that in Shuang-Huang-Lian, can be improved significa …
Origin and Formation Mechanism Investigation of Compound Precipitation from the Traditional Chinese Prescription Huang-Lian-Jie-Du-Tang by Isothermal Titration Calorimetry.
Wang H, Li T, Xiang H, Zhang X, Fang K, Wu G, Yan M, Xue N, Chen M, Xie T, Zhang Y, Wang P, Lei H. Wang H, et al. Molecules. 2017 Sep 1;22(9):1456. doi: 10.3390/molecules22091456. Molecules. 2017. PMID: 28862668 Free PMC article.
Previous studies have shown that compounds in the form of precipitate (CFP) from Huang-Lian-Jie-Du-Tang (HLJDT) were stable, and the CFP content reached 2.63% of the whole decoction and had good neuroprotective effects. ...
Previous studies have shown that compounds in the form of precipitate (CFP) from Huang-Lian-Jie-Du-Tang (HLJDT) were stable, and the …
[Establishment of a model of hydrogen peroxide-induced injury in pulmonary artery endothelium cells and relevant mechanisms of oxidative stress].
Ye J, He YY, Yan Y, Zhao JH, Lian TY, Wang XJ, Yan Y, Zhang SJ, Yang SH, Jing ZC. Ye J, et al. Zhonghua Xin Xue Guan Bing Za Zhi. 2017 Jul 24;45(7):613-618. doi: 10.3760/cma.j.issn.0253-3758.2017.07.011. Zhonghua Xin Xue Guan Bing Za Zhi. 2017. PMID: 28738491 Chinese.
Proteins were extracted and the phosphorylation levels of signal molecules in PAECs were detected by Western blot assays. Results: (1) The effect of H(2)O(2) at various concentrations on cell viability of PAECs: cell viability of PAECs decreased in proportion to increasing …
Proteins were extracted and the phosphorylation levels of signal molecules in PAECs were detected by Western blot assays. Results: (1 …
Simultaneous Determination of Multiple Classes of Hydrophilic and Lipophilic Components in Shuang-Huang-Lian Oral Liquid Formulations by UPLC-Triple Quadrupole Linear Ion Trap Mass Spectrometry.
Liang J, Sun HM, Wang TL. Liang J, et al. Molecules. 2017 Nov 24;22(12):2057. doi: 10.3390/molecules22122057. Molecules. 2017. PMID: 29186758 Free PMC article.
The Shuang-Huang-Lian (SHL) oral liquid is a combined herbal prescription used in the treatment of acute upper respiratory tract infection, acute bronchitis and pneumonia. ...
The Shuang-Huang-Lian (SHL) oral liquid is a combined herbal prescription used in the treatment of acute upper respiratory tract infe …