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Inceptor counteracts insulin signalling in beta-cells to control glycaemia.
Nature. 2021 Feb;590(7845):326-331. doi: 10.1038/s41586-021-03225-8. Epub 2021 Jan 27.
Nature. 2021.
PMID: 33505018
Blocking this physical interaction using monoclonal antibodies against the extracellular domain of inceptor resulted in the retention of inceptor and INSR at the plasma membrane to sustain the activation of INSR-IGF1R in beta-cells. Together, our findings show that …
Blocking this physical interaction using monoclonal antibodies against the extracellular domain of inceptor resulted in the retention …
Inceptor correlates with markers of prostate cancer progression and modulates insulin/IGF1 signaling and cancer cell migration.
Wissmiller K, Bilekova S, Franko A, Lutz SZ, Katsburg M, Gulde S, Pellegata NS, Stenzl A, Heni M, Berti L, Häring HU, Lickert H.
Wissmiller K, et al.
Mol Metab. 2023 May;71:101706. doi: 10.1016/j.molmet.2023.101706. Epub 2023 Mar 15.
Mol Metab. 2023.
PMID: 36931467
Free PMC article.
Therefore, we investigated the role of the novel insulin/IGF1 signaling modulator inceptor in prostate cancer. METHODS: We analyzed the expression of inceptor in human samples of benign prostate epithelium and prostate cancer. ...Taken together, these data provide a …
Therefore, we investigated the role of the novel insulin/IGF1 signaling modulator inceptor in prostate cancer. METHODS: We analyzed t …
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Inceptor facilitates acrosomal vesicle formation in spermatids and is required for male fertility.
Bilekova S, Garcia-Colomer B, Cebrian-Serrano A, Schirge S, Krey K, Sterr M, Kurth T, Hauck SM, Lickert H.
Bilekova S, et al.
Front Cell Dev Biol. 2023 Aug 24;11:1240039. doi: 10.3389/fcell.2023.1240039. eCollection 2023.
Front Cell Dev Biol. 2023.
PMID: 37691832
Free PMC article.
In this study, we investigated the role of the insulin inhibitory receptor (inceptor) in acrosome formation. Inceptor is a single-pass transmembrane protein with similarities to mannose-6-phosphate receptors (M6PR). ...The absence of inceptor results in vesic …
In this study, we investigated the role of the insulin inhibitory receptor (inceptor) in acrosome formation. Inceptor is a sin …
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Global, neuronal or beta cell-specific deletion of inceptor improves glucose homeostasis in male mice with diet-induced obesity.
Grandl G, Collden G, Feng J, Bhattacharya S, Klingelhuber F, Schomann L, Bilekova S, Ansarullah, Xu W, Far FF, Tost M, Gruber T, Bastidas-Ponce A, Zhang Q, Novikoff A, Liskiewicz A, Liskiewicz D, Garcia-Caceres C, Feuchtinger A, Tschöp MH, Krahmer N, Lickert H, Müller TD.
Grandl G, et al.
Nat Metab. 2024 Mar;6(3):448-457. doi: 10.1038/s42255-024-00991-3. Epub 2024 Feb 28.
Nat Metab. 2024.
PMID: 38418586
Free PMC article.
Moreover, we demonstrate that inceptor-mediated improvement in glucose control does not depend on inceptor function in agouti-related protein-expressing or pro-opiomelanocortin neurons. Our data demonstrate that inceptor inhibition improves glucose homeostasi …
Moreover, we demonstrate that inceptor-mediated improvement in glucose control does not depend on inceptor function in agouti- …
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Author Correction: Inceptor counteracts insulin signalling in beta-cells to control glycaemia.
Ansarullah, Jain C, Far FF, Homberg S, Wißmiller K, von Hahn FG, Raducanu A, Schirge S, Sterr M, Bilekova S, Siehler J, Wiener J, Oppenländer L, Morshedi A, Bastidas-Ponce A, Collden G, Irmler M, Beckers J, Feuchtinger A, Grzybek M, Ahlbrecht C, Feederle R, Plettenburg O, Müller TD, Meier M, Tschöp MH, Coskun Ü, Lickert H.
Ansarullah, et al.
Nature. 2021 Apr;592(7852):E1. doi: 10.1038/s41586-021-03347-z.
Nature. 2021.
PMID: 33712809
No abstract available.
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