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Licochalcone C Inhibits the Growth of Human Colorectal Cancer HCT116 Cells Resistant to Oxaliplatin.
Lee SO, Joo SH, Lee JY, Kwak AW, Kim KT, Cho SS, Yoon G, Choi YH, Park JW, Shim JH. Lee SO, et al. Biomol Ther (Seoul). 2024 Jan 1;32(1):104-114. doi: 10.4062/biomolther.2023.167. Biomol Ther (Seoul). 2024. PMID: 38148556 Free PMC article.
Licochalcone C (LCC; PubChem CID:9840805), a chalcone compound originating from the root of Glycyrrhiza inflata, has shown anticancer activity against skin cancer, esophageal squamous cell carcinoma, and oral squamous cell carcinoma. ...
Licochalcone C (LCC; PubChem CID:9840805), a chalcone compound originating from the root of Glycyrrhiza inflata, has shown ant …
Network Pharmacology Combined with Machine Learning to Reveal the Action Mechanism of Licochalcone Intervention in Liver Cancer.
Guo F, Yang X, Hu C, Li W, Han W. Guo F, et al. Int J Mol Sci. 2023 Nov 3;24(21):15935. doi: 10.3390/ijms242115935. Int J Mol Sci. 2023. PMID: 37958916 Free PMC article.
This study aims to reveal the potential mechanisms of licochalcone A (LCA), licochalcone B (LCB), licochalcone C (LCC), licochalcone D (LCD), licochalcone E (LCE), licochalcone F (LCF), and licochalcone G (LCG) inhibition in liver cancer through computer-aided scree …
This study aims to reveal the potential mechanisms of licochalcone A (LCA), licochalcone B (LCB), licochalcone C (LCC), licoch …
Licochalcone H Targets EGFR and AKT to Suppress the Growth of Oxaliplatin -Sensitive and -Resistant Colorectal Cancer Cells.
Lee SO, Lee MH, Kwak AW, Lee JY, Yoon G, Joo SH, Choi YH, Park JW, Shim JH. Lee SO, et al. Biomol Ther (Seoul). 2023 Nov 1;31(6):661-673. doi: 10.4062/biomolther.2023.155. Biomol Ther (Seoul). 2023. PMID: 37899744 Free PMC article.
We investigated the antiproliferative activity of licochalcone H (LCH), a regioisomer of licochalcone C derived from the root of Glycyrrhiza inflata, in oxaliplatin (Ox)-sensitive and -resistant CRC cells. ...
We investigated the antiproliferative activity of licochalcone H (LCH), a regioisomer of licochalcone C derived from the root …
Anticancer effects of licochalcones: A review of the mechanisms.
Deng N, Qiao M, Li Y, Liang F, Li J, Liu Y. Deng N, et al. Front Pharmacol. 2023 Jan 23;14:1074506. doi: 10.3389/fphar.2023.1074506. eCollection 2023. Front Pharmacol. 2023. PMID: 36755942 Free PMC article.
Licorice is a widely used traditional Chinese medicine with various pharmacological properties, and licorice-derived flavonoids include licochalcones like licochalcone A, licochalcone B, licochalcone C, licochalcone D, licochalcone E, and licochalcone H. By regulati …
Licorice is a widely used traditional Chinese medicine with various pharmacological properties, and licorice-derived flavonoids include lico …
Licochalcone H Induces Cell Cycle Arrest and Apoptosis in Human Skin Cancer Cells by Modulating JAK2/STAT3 Signaling.
Park KH, Joo SH, Seo JH, Kim J, Yoon G, Jeon YJ, Lee MH, Chae JI, Kim WK, Shim JH. Park KH, et al. Biomol Ther (Seoul). 2022 Jan 1;30(1):72-79. doi: 10.4062/biomolther.2021.149. Biomol Ther (Seoul). 2022. PMID: 34873073 Free PMC article.
Licochalcone H (LCH) is a phenolic compound synthetically derived from licochalcone C (LCC) that exerts anticancer activity. In this study, we investigated the anticancer activity of LCH in human skin cancer A375 and A431 cells. ...
Licochalcone H (LCH) is a phenolic compound synthetically derived from licochalcone C (LCC) that exerts anticancer activity. I …
Inhibition of drug-metabolizing enzymes by Jingyin granules: implications of herb-drug interactions in antiviral therapy.
Zhang F, Liu W, Huang J, Chen QL, Wang DD, Zou LW, Zhao YF, Zhang WD, Xu JG, Chen HZ, Ge GB. Zhang F, et al. Acta Pharmacol Sin. 2022 Apr;43(4):1072-1081. doi: 10.1038/s41401-021-00697-2. Epub 2021 Jun 28. Acta Pharmacol Sin. 2022. PMID: 34183756 Free PMC article.
Further investigation revealed licochalcone A, licochalcone B, licochalcone C and echinatin in Radix Glycyrrhizae, as well as quercetin and kaempferol in Folium Llicis Purpureae, to be time-dependent CYP3A inhibitors. ...
Further investigation revealed licochalcone A, licochalcone B, licochalcone C and echinatin in Radix Glycyrrhizae, as well as …
Spectrum-Effect Relationships of Flavonoids in Glycyrrhiza uralensis Fisch.
Li T, Hua S, Ma J, Dong L, Xu F, Fu X. Li T, et al. J Anal Methods Chem. 2020 Dec 3;2020:8838290. doi: 10.1155/2020/8838290. eCollection 2020. J Anal Methods Chem. 2020. PMID: 33343964 Free PMC article.
After HPLC-quadrupole time-of-flight mass spectrometry and standard comparison, these five identified compounds (liquiritin apioside, neoisoliquiritin, licochalcone A, licochalcone B, and licochalcone C) could be used to evaluate licorice quality with regard to its …
After HPLC-quadrupole time-of-flight mass spectrometry and standard comparison, these five identified compounds (liquiritin apioside, neoiso …
Discovery of hCES2A inhibitors from Glycyrrhiza inflata via combination of docking-based virtual screening and fluorescence-based inhibition assays.
Song YQ, Guan XQ, Weng ZM, Liu JL, Chen J, Wang L, Cui LT, Fang SQ, Hou J, Ge GB. Song YQ, et al. Food Funct. 2021 Jan 7;12(1):162-176. doi: 10.1039/d0fo02140g. Epub 2020 Dec 8. Food Funct. 2021. PMID: 33291124
Inhibition kinetic analysis demonstrated that licochalcone A, licochalcone C, licochalcone D and isolicoflavonol potently inhibited hCES2A-mediated fluorescein diacetate hydrolysis in a reversible and mixed inhibition manner, with K(i) values less than 1.0 muM. Furt …
Inhibition kinetic analysis demonstrated that licochalcone A, licochalcone C, licochalcone D and isolicoflavonol potently inhi …
Licochalcone C induces cell cycle G1 arrest and apoptosis in human esophageal squamous carcinoma cells by activation of the ROS/MAPK signaling pathway.
Kwak AW, Choi JS, Liu K, Lee MH, Jeon YJ, Cho SS, Yoon G, Oh HN, Chae JI, Shim JH. Kwak AW, et al. J Chemother. 2020 May;32(3):132-143. doi: 10.1080/1120009X.2020.1721175. Epub 2020 Feb 3. J Chemother. 2020. PMID: 32009586
Since chemotherapy for esophageal cancer has significant side effects, phytochemicals have attracted attention as an alternative medicine. Licochalcone C (LCC) is a flavonoid compound extracted from Licorice, with a variety of clinical uses including anti-cancer, an …
Since chemotherapy for esophageal cancer has significant side effects, phytochemicals have attracted attention as an alternative medicine. …
Microbial Transformation of Licochalcones.
Xiao Y, Han F, Lee IS. Xiao Y, et al. Molecules. 2019 Dec 23;25(1):60. doi: 10.3390/molecules25010060. Molecules. 2019. PMID: 31878031 Free PMC article.
24 results