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Inhibiting de novo ceramide synthesis restores mitochondrial and protein homeostasis in muscle aging.
Lima TI, Laurila PP, Wohlwend M, Morel JD, Goeminne LJE, Li H, Romani M, Li X, Oh CM, Park D, Rodríguez-López S, Ivanisevic J, Gallart-Ayala H, Crisol B, Delort F, Batonnet-Pichon S, Silveira LR, Sankabattula Pavani Veera Venkata L, Padala AK, Jain S, Auwerx J. Lima TI, et al. Sci Transl Med. 2023 May 17;15(696):eade6509. doi: 10.1126/scitranslmed.ade6509. Epub 2023 May 17. Sci Transl Med. 2023. PMID: 37196064
The exercise-induced long noncoding RNA CYTOR promotes fast-twitch myogenesis in aging.
Wohlwend M, Laurila PP, Williams K, Romani M, Lima T, Pattawaran P, Benegiamo G, Salonen M, Schneider BL, Lahti J, Eriksson JG, Barrès R, Wisløff U, Moreira JBN, Auwerx J. Wohlwend M, et al. Sci Transl Med. 2021 Dec 8;13(623):eabc7367. doi: 10.1126/scitranslmed.abc7367. Epub 2021 Dec 8. Sci Transl Med. 2021. PMID: 34878822
Opposing action of NCoR1 and PGC-1α in mitochondrial redox homeostasis.
Lima TI, Guimarães DSPSF, Oliveira AG, Araujo H, Sponton CHG, Souza-Pinto NC, Saito Â, Figueira ACM, Palameta S, Bajgelman MC, Calixto A, Pinto S, Mori MA, Orofino J, Perissi V, Mottis A, Auwerx J, Silveira LR. Lima TI, et al. Free Radic Biol Med. 2019 Nov 1;143:203-208. doi: 10.1016/j.freeradbiomed.2019.08.006. Epub 2019 Aug 10. Free Radic Biol Med. 2019. PMID: 31408725
Role of NCoR1 in mitochondrial function and energy metabolism.
Lima TI, Valentim RR, Araújo HN, Oliveira AG, Favero BC, Menezes ES, Araújo R, Silveira LR. Lima TI, et al. Cell Biol Int. 2018 Jun;42(6):734-741. doi: 10.1002/cbin.10973. Epub 2018 May 8. Cell Biol Int. 2018. PMID: 29660213 Review.
Interaction between poly(A)-binding protein PABPC4 and nuclear receptor corepressor NCoR1 modulates a metabolic stress response.
Oliveira AG, Oliveira LD, Cruz MV, Guimarães DSPSF, Lima TI, Santos-Fávero BC, Luchessi AD, Pauletti BA, Leme AP, Bajgelman MC, Afonso J, Regitano LCA, Carvalho HF, Carneiro EM, Kobarg J, Perissi V, Auwerx J, Silveira LR. Oliveira AG, et al. Among authors: lima ti. J Biol Chem. 2023 Jun;299(6):104702. doi: 10.1016/j.jbc.2023.104702. Epub 2023 Apr 12. J Biol Chem. 2023. PMID: 37059182 Free PMC article.
Essential role of the PGC-1α/PPARβ axis in Ucp3 gene induction.
Lima TI, Guimarães D, Sponton CH, Bajgelman MC, Palameta S, Toscaro JM, Reis O, Silveira LR. Lima TI, et al. J Physiol. 2019 Aug;597(16):4277-4291. doi: 10.1113/JP278006. Epub 2019 Jul 17. J Physiol. 2019. PMID: 31228206 Free article.
Offspring from trained male mice inherit improved muscle mitochondrial function through PPAR co-repressor modulation.
Freitas-Dias R, Lima TI, Costa-Junior JM, Gonçalves LM, Araujo HN, Paula FMM, Santos GJ, Branco RCS, Ou K, Kaestner KH, Silveira LR, Oliveira CAM, Boschero AC, Zoppi CC, Carneiro EM. Freitas-Dias R, et al. Among authors: lima ti. Life Sci. 2022 Feb 15;291:120239. doi: 10.1016/j.lfs.2021.120239. Epub 2021 Dec 21. Life Sci. 2022. PMID: 34942163
28 results