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Discovery, structure-activity relationship studies, and anti-nociceptive effects of N-(1,2,3,4-tetrahydro-1-isoquinolinylmethyl)benzamides as novel opioid receptor agonists.
Chen SR, Ke YY, Yeh TK, Lin SY, Ou LC, Chen SC, Chang WT, Chang HF, Wu ZH, Hsieh CC, Law PY, Loh HH, Shih C, Lai YK, Yeh SH, Ueng SH. Chen SR, et al. Among authors: lin sy. Eur J Med Chem. 2017 Jan 27;126:202-217. doi: 10.1016/j.ejmech.2016.09.003. Epub 2016 Sep 20. Eur J Med Chem. 2017. PMID: 27776274
Chikungunya virus inhibition by synthetic coumarin-guanosine conjugates.
Hwu JR, Huang WC, Lin SY, Tan KT, Hu YC, Shieh FK, Bachurin SO, Ustyugov A, Tsay SC. Hwu JR, et al. Among authors: lin sy. Eur J Med Chem. 2019 Mar 15;166:136-143. doi: 10.1016/j.ejmech.2019.01.037. Epub 2019 Jan 21. Eur J Med Chem. 2019. PMID: 30703657
Discovery of a Furanopyrimidine-Based Epidermal Growth Factor Receptor Inhibitor (DBPR112) as a Clinical Candidate for the Treatment of Non-Small Cell Lung Cancer.
Lin SY, Chang Hsu Y, Peng YH, Ke YY, Lin WH, Sun HY, Shiao HY, Kuo FM, Chen PY, Lien TW, Chen CH, Chu CY, Wang SY, Yeh KC, Chen CP, Hsu TA, Wu SY, Yeh TK, Chen CT, Hsieh HP. Lin SY, et al. Among authors: lin wh. J Med Chem. 2019 Nov 27;62(22):10108-10123. doi: 10.1021/acs.jmedchem.9b00722. Epub 2019 Nov 15. J Med Chem. 2019. PMID: 31560541
Development of Furanopyrimidine-Based Orally Active Third-Generation EGFR Inhibitors for the Treatment of Non-Small Cell Lung Cancer.
Li MC, Coumar MS, Lin SY, Lin YS, Huang GL, Chen CH, Lien TW, Wu YW, Chen YT, Chen CP, Huang YC, Yeh KC, Yang CM, Kalita B, Pan SL, Hsu TA, Yeh TK, Chen CT, Hsieh HP. Li MC, et al. Among authors: lin sy, lin ys. J Med Chem. 2023 Feb 23;66(4):2566-2588. doi: 10.1021/acs.jmedchem.2c01434. Epub 2023 Feb 7. J Med Chem. 2023. PMID: 36749735 Free PMC article.
Identification of Substituted Naphthotriazolediones as Novel Tryptophan 2,3-Dioxygenase (TDO) Inhibitors through Structure-Based Virtual Screening.
Wu JS, Lin SY, Liao FY, Hsiao WC, Lee LC, Peng YH, Hsieh CL, Wu MH, Song JS, Yueh A, Chen CH, Yeh SH, Liu CY, Lin SY, Yeh TK, Hsu JT, Shih C, Ueng SH, Hung MS, Wu SY. Wu JS, et al. Among authors: lin sy. J Med Chem. 2015 Oct 8;58(19):7807-19. doi: 10.1021/acs.jmedchem.5b00921. Epub 2015 Sep 16. J Med Chem. 2015. PMID: 26348881
Important Hydrogen Bond Networks in Indoleamine 2,3-Dioxygenase 1 (IDO1) Inhibitor Design Revealed by Crystal Structures of Imidazoleisoindole Derivatives with IDO1.
Peng YH, Ueng SH, Tseng CT, Hung MS, Song JS, Wu JS, Liao FY, Fan YS, Wu MH, Hsiao WC, Hsueh CC, Lin SY, Cheng CY, Tu CH, Lee LC, Cheng MF, Shia KS, Shih C, Wu SY. Peng YH, et al. Among authors: lin sy. J Med Chem. 2016 Jan 14;59(1):282-93. doi: 10.1021/acs.jmedchem.5b01390. Epub 2015 Dec 21. J Med Chem. 2016. PMID: 26642377
2,849 results