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Chemical and structural studies provide a mechanistic basis for recognition of the MYC G-quadruplex.
Calabrese DR, Chen X, Leon EC, Gaikwad SM, Phyo Z, Hewitt WM, Alden S, Hilimire TA, He F, Michalowski AM, Simmons JK, Saunders LB, Zhang S, Connors D, Walters KJ, Mock BA, Schneekloth JS Jr. Calabrese DR, et al. Among authors: saunders lb. Nat Commun. 2018 Oct 12;9(1):4229. doi: 10.1038/s41467-018-06315-w. Nat Commun. 2018. PMID: 30315240 Free PMC article.
Insights Into the Allosteric Inhibition of the SUMO E2 Enzyme Ubc9.
Hewitt WM, Lountos GT, Zlotkowski K, Dahlhauser SD, Saunders LB, Needle D, Tropea JE, Zhan C, Wei G, Ma B, Nussinov R, Waugh DS, Schneekloth JS Jr. Hewitt WM, et al. Among authors: saunders lb. Angew Chem Int Ed Engl. 2016 May 4;55(19):5703-7. doi: 10.1002/anie.201511351. Epub 2016 Apr 1. Angew Chem Int Ed Engl. 2016. PMID: 27038327 Free PMC article.