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Role of multiple drug resistance protein 1 in neutral but not acidic glycosphingolipid biosynthesis.
De Rosa MF, Sillence D, Ackerley C, Lingwood C. De Rosa MF, et al. Among authors: lingwood c. J Biol Chem. 2004 Feb 27;279(9):7867-76. doi: 10.1074/jbc.M305645200. Epub 2003 Dec 8. J Biol Chem. 2004. PMID: 14662772 Free article.
Transfection studies have implicated the multiple drug resistance pump, MDR1, as a glucosyl ceramide translocase within the Golgi complex (Lala, P., Ito, S., and Lingwood, C. A. (2000) J. Biol. Chem. 275, 6246-6251). We now show that MDR1 inhibitors, cyclosporin A o …
Transfection studies have implicated the multiple drug resistance pump, MDR1, as a glucosyl ceramide translocase within the Golgi complex (L …
Treatment of neutral glycosphingolipid lysosomal storage diseases via inhibition of the ABC drug transporter, MDR1. Cyclosporin A can lower serum and liver globotriaosyl ceramide levels in the Fabry mouse model.
Mattocks M, Bagovich M, De Rosa M, Bond S, Binnington B, Rasaiah VI, Medin J, Lingwood C. Mattocks M, et al. Among authors: lingwood c. FEBS J. 2006 May;273(9):2064-75. doi: 10.1111/j.1742-4658.2006.05223.x. FEBS J. 2006. PMID: 16724420 Free article.
The medium is the message: glycosphingolipids and their soluble analogues.
De Rosa M, Park HJ, Mylvaganum M, Binnington B, Lund N, Branch DR, Lingwood CA. De Rosa M, et al. Among authors: lingwood ca. Biochim Biophys Acta. 2008 Mar;1780(3):347-52. doi: 10.1016/j.bbagen.2007.10.016. Epub 2007 Nov 4. Biochim Biophys Acta. 2008. PMID: 18022400 Review.
204 results