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Investigation of Linum flavum (L.) Hairy Root Cultures for the Production of Anticancer Aryltetralin Lignans.
Renouard S, Corbin C, Drouet S, Medvedec B, Doussot J, Colas C, Maunit B, Bhambra AS, Gontier E, Jullian N, Mesnard F, Boitel M, Abbasi BH, Arroo RRJ, Lainé E, Hano C. Renouard S, et al. Int J Mol Sci. 2018 Mar 26;19(4):990. doi: 10.3390/ijms19040990. Int J Mol Sci. 2018. PMID: 29587452 Free PMC article.
Linum flavum hairy root lines were established from hypocotyl pieces using Agrobacterium rhizogenes strains LBA 9402 and ATCC 15834. ...These results point to the use of hairy root culture lines of Linum flavum as potential sources for these valuable m …
Linum flavum hairy root lines were established from hypocotyl pieces using Agrobacterium rhizogenes strains LBA 9402 and ATCC …
Enhanced Aryltetralin Lignans Production in Linum Adventi-Tious Root Cultures.
Alfieri M, Mascheretti I, Dougué Kentsop RA, Consonni R, Locatelli F, Mattana M, Ottolina G. Alfieri M, et al. Molecules. 2021 Aug 27;26(17):5189. doi: 10.3390/molecules26175189. Molecules. 2021. PMID: 34500623 Free PMC article.
Lignans are the main secondary metabolites synthetized by Linum species as plant defense molecules. They are also valuable for human health, in particular, for their potent antiviral and antineoplastic properties. In this study, the adventitious root cultures of three L …
Lignans are the main secondary metabolites synthetized by Linum species as plant defense molecules. They are also valuable for human …
Dirigent-mediated podophyllotoxin biosynthesis in Linum flavum and Podophyllum peltatum.
Xia ZQ, Costa MA, Proctor J, Davin LB, Lewis NG. Xia ZQ, et al. Phytochemistry. 2000 Nov;55(6):537-49. doi: 10.1016/s0031-9422(00)00242-9. Phytochemistry. 2000. PMID: 11130663
Given the importance of the antitumor/antiviral lignans, podophyllotoxin and 5-methoxypodophyllotoxin, as biotechnological targets, their biosynthetic pathways were investigated in Podophyllum peltatum and Linum flavum. Entry into their pathways was established to o …
Given the importance of the antitumor/antiviral lignans, podophyllotoxin and 5-methoxypodophyllotoxin, as biotechnological targets, their bi …
Biotechnological Approaches for Production of Anti-Cancerous Compounds Resveratrol, Podophyllotoxin and Zerumbone.
Nandagopal K, Halder M, Dash B, Nayak S, Jha S. Nandagopal K, et al. Curr Med Chem. 2018;25(36):4693-4717. doi: 10.2174/0929867324666170404145656. Curr Med Chem. 2018. PMID: 28393691 Review.
Interestingly, genetic transformation of Podophyllum hexandrum and Linum flavum with Agrobacterium rhizogenes resulted in Ri-T-DNA gene(s)-mediated enhancement of podophyllotoxin production. ...
Interestingly, genetic transformation of Podophyllum hexandrum and Linum flavum with Agrobacterium rhizogenes resulted in Ri-T …
Lignans in seeds of Linum species.
Schmidt TJ, Klaes M, Sendker J. Schmidt TJ, et al. Phytochemistry. 2012 Oct;82:89-99. doi: 10.1016/j.phytochem.2012.07.004. Epub 2012 Jul 31. Phytochemistry. 2012. PMID: 22854497
Mature seeds of 20 Linum species were analyzed for their content of lignans. The seeds of common flax (Linum usitatissimum L.) are known to contain as characteristic lignan sesoisolariciresinol diglucoside (SDG), whose presence in seeds of some other Linum …
Mature seeds of 20 Linum species were analyzed for their content of lignans. The seeds of common flax (Linum usitatissi …
Kinetics of glucosylated and non-glucosylated aryltetralin lignans in Linum hairy root cultures.
Cong LH, Dauwe R, Lequart M, Vinchon S, Renouard S, Fliniaux O, Colas C, Corbin C, Doussot J, Hano C, Lamblin F, Molinié R, Pilard S, Jullian N, Boitel M, Gontier E, Mesnard F, Laberche JC. Cong LH, et al. Phytochemistry. 2015 Jul;115:70-8. doi: 10.1016/j.phytochem.2015.01.001. Epub 2015 Feb 16. Phytochemistry. 2015. PMID: 25698360
This work reports on the growth and ATL biosynthesis in two hairy root cultures of Linum album Kotschy ex Boiss. and Linum flavum. The kinetics of accumulation of the intermediates of MPTOX biosynthesis and of their glucosylated forms are described over a 21- …
This work reports on the growth and ATL biosynthesis in two hairy root cultures of Linum album Kotschy ex Boiss. and Linum …
Development of Linum flavum hairy root cultures for production of coniferin.
Lin HW, Kwok KH, Doran PM. Lin HW, et al. Biotechnol Lett. 2003 Apr;25(7):521-5. doi: 10.1023/a:1022821600283. Biotechnol Lett. 2003. PMID: 12882138
Linum flavum hairy roots were initiated from leaf discs using Agrobacterium rhizogenes strains LBA9402 and TR105 though two other strains, 15834 and A4, were relatively ineffective for induction. Significant variation in coniferin accumulation was observed between h …
Linum flavum hairy roots were initiated from leaf discs using Agrobacterium rhizogenes strains LBA9402 and TR105 though two ot …
6-methoxypodophyllotoxin-7-O-n-hexanoate, a new aryltetralin lignan ester from seeds of Linum flavum.
Klaes M, Ellendorff T, Schmidt TJ. Klaes M, et al. Planta Med. 2010 May;76(7):719-21. doi: 10.1055/s-0029-1240674. Epub 2009 Dec 3. Planta Med. 2010. PMID: 19960414
A new aryltetralin-type lignan, 6-methoxypodophyllotoxin-7- O-n-hexanoate, was isolated from the seeds of Linum flavum L. var. compactum (Linaceae) by silica gel column chromatography of the dichloromethane extract. ...The occurrence of aryltetralin lignans, which a …
A new aryltetralin-type lignan, 6-methoxypodophyllotoxin-7- O-n-hexanoate, was isolated from the seeds of Linum flavum L. var. …
Deoxypodophyllotoxin 6-hydroxylase, a cytochrome P450 monooxygenase from cell cultures of Linum flavum involved in the biosynthesis of cytotoxic lignans.
Molog GA, Empt U, Kuhlmann S, van Uden W, Pras N, Alfermann AW, Petersen M. Molog GA, et al. Planta. 2001 Dec;214(2):288-94. doi: 10.1007/s004250100617. Planta. 2001. PMID: 11800394
Cell-suspension cultures of Linum flavum L. (Linaceae) synthesize and accumulate aryltetrahydronaphthalene lignans with 6-methoxypodophyllotoxin as the main component. ...
Cell-suspension cultures of Linum flavum L. (Linaceae) synthesize and accumulate aryltetrahydronaphthalene lignans with 6-meth …
Investigation of the Lignan Content in Extracts from Linum, Callitris and Juniperus Species in Relation to Their In Vitro Antiproliferative Activities.
Doussot J, Mathieu V, Colas C, Molinié R, Corbin C, Montguillon J, Moreno Y Banuls L, Renouard S, Lamblin F, Dupré P, Maunit B, Kiss R, Hano C, Lainé E. Doussot J, et al. Planta Med. 2017 Apr;83(6):574-581. doi: 10.1055/s-0042-118650. Epub 2016 Oct 24. Planta Med. 2017. PMID: 27776375
Plants belonging to the Linaceae and Cupressaceae families could be attractive alternative sources with species that contain the lignan podophyllotoxin or its precursors and derivatives. Wild flax species, such as Linum flavum, as well as some Juniperus and C …
Plants belonging to the Linaceae and Cupressaceae families could be attractive alternative sources with species that contain the lignan podo …
28 results