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In utero and postnatal VX-770 administration rescues multiorgan disease in a ferret model of cystic fibrosis.
Sci Transl Med. 2019 Mar 27;11(485):eaau7531. doi: 10.1126/scitranslmed.aau7531.
Sci Transl Med. 2019.
PMID: 30918114
Free PMC article.
Identification of novel HSP90α/β isoform selective inhibitors using structure-based drug design. demonstration of potential utility in treating CNS disorders such as Huntington's disease.
Ernst JT, Neubert T, Liu M, Sperry S, Zuccola H, Turnbull A, Fleck B, Kargo W, Woody L, Chiang P, Tran D, Chen W, Snyder P, Alcacio T, Nezami A, Reynolds J, Alvi K, Goulet L, Stamos D.
Ernst JT, et al. Among authors: woody l.
J Med Chem. 2014 Apr 24;57(8):3382-400. doi: 10.1021/jm500042s. Epub 2014 Apr 10.
J Med Chem. 2014.
PMID: 24673104
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Discovery of novel oxazepine and diazepine carboxamides as two new classes of heat shock protein 90 inhibitors.
Neubert T, Numa M, Ernst J, Clemens J, Krenitsky P, Liu M, Fleck B, Woody L, Zuccola H, Stamos D.
Neubert T, et al. Among authors: woody l.
Bioorg Med Chem Lett. 2015 Mar 15;25(6):1338-42. doi: 10.1016/j.bmcl.2015.01.023. Epub 2015 Jan 20.
Bioorg Med Chem Lett. 2015.
PMID: 25677667
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