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Identification of Therapeutic Targets for Amyotrophic Lateral Sclerosis Using PandaOmics - An AI-Enabled Biological Target Discovery Platform.
Front Aging Neurosci. 2022 Jun 28;14:914017. doi: 10.3389/fnagi.2022.914017. eCollection 2022.
Front Aging Neurosci. 2022.
PMID: 35837482
Free PMC article.
Hallmarks of aging-based dual-purpose disease and age-associated targets predicted using PandaOmics AI-powered discovery engine.
Pun FW, Leung GHD, Leung HW, Liu BHM, Long X, Ozerov IV, Wang J, Ren F, Aliper A, Izumchenko E, Moskalev A, de Magalhães JP, Zhavoronkov A.
Pun FW, et al. Among authors: liu bhm.
Aging (Albany NY). 2022 Mar 29;14(6):2475-2506. doi: 10.18632/aging.203960. Epub 2022 Mar 29.
Aging (Albany NY). 2022.
PMID: 35347083
Free PMC article.
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Biomedical generative pre-trained based transformer language model for age-related disease target discovery.
Zagirova D, Pushkov S, Leung GHD, Liu BHM, Urban A, Sidorenko D, Kalashnikov A, Kozlova E, Naumov V, Pun FW, Ozerov IV, Aliper A, Zhavoronkov A.
Zagirova D, et al. Among authors: liu bhm.
Aging (Albany NY). 2023 Sep 22;15(18):9293-9309. doi: 10.18632/aging.205055. Epub 2023 Sep 22.
Aging (Albany NY). 2023.
PMID: 37742294
Free PMC article.
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A comprehensive AI-driven analysis of large-scale omic datasets reveals novel dual-purpose targets for the treatment of cancer and aging.
Pun FW, Leung GHD, Leung HW, Rice J, Schmauck-Medina T, Lautrup S, Long X, Liu BHM, Wong CW, Ozerov IV, Aliper A, Ren F, Rosenberg AJ, Agrawal N, Izumchenko E, Fang EF, Zhavoronkov A.
Pun FW, et al. Among authors: liu bhm.
Aging Cell. 2023 Dec;22(12):e14017. doi: 10.1111/acel.14017. Epub 2023 Oct 27.
Aging Cell. 2023.
PMID: 37888486
Free PMC article.
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TPI1-reduced extracellular vesicles mediated by Rab20 downregulation promotes aerobic glycolysis to drive hepatocarcinogenesis.
Liu BHM, Tey SK, Mao X, Ma APY, Yeung CLS, Wong SWK, Ng TH, Xu Y, Yao Y, Fung EYM, Tan KV, Khong PL, Ho DW, Ng IO, Tang AHN, Cai SH, Yun JP, Yam JWP.
Liu BHM, et al.
J Extracell Vesicles. 2021 Aug;10(10):e12135. doi: 10.1002/jev2.12135. Epub 2021 Aug 11.
J Extracell Vesicles. 2021.
PMID: 34401050
Free PMC article.
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Tumour extracellular vesicle-derived Complement Factor H promotes tumorigenesis and metastasis by inhibiting complement-dependent cytotoxicity of tumour cells.
Mao X, Zhou L, Tey SK, Ma APY, Yeung CLS, Ng TH, Wong SWK, Liu BHM, Fung YME, Patz EF Jr, Cao P, Gao Y, Yam JWP.
Mao X, et al. Among authors: liu bhm.
J Extracell Vesicles. 2020 Nov;10(1):e12031. doi: 10.1002/jev2.12031. Epub 2020 Nov 28.
J Extracell Vesicles. 2020.
PMID: 33708358
Free PMC article.
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Galectin-1 promotes hepatocellular carcinoma and the combined therapeutic effect of OTX008 galectin-1 inhibitor and sorafenib in tumor cells.
Leung Z, Ko FCF, Tey SK, Kwong EML, Mao X, Liu BHM, Ma APY, Fung YME, Che CM, Wong DKH, Lai CL, Ng IO, Yam JWP.
Leung Z, et al. Among authors: liu bhm.
J Exp Clin Cancer Res. 2019 Oct 22;38(1):423. doi: 10.1186/s13046-019-1402-x.
J Exp Clin Cancer Res. 2019.
PMID: 31640796
Free PMC article.
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