The synthesized transporter K16APoE enabled the therapeutic HAYED peptide to cross the blood-brain barrier and remove excess iron and radicals in the brain, thus easing Alzheimer's disease.
Zou Z, Shen Q, Pang Y, Li X, Chen Y, Wang X, Luo X, Wu Z, Bao Z, Zhang J, Liang J, Kong L, Yan L, Xiong L, Zhu T, Yuan S, Wang M, Cai K, Yao Y, Wu J, Jiang Y, Liu H, Liu J, Zhou Y, Dong Q, Wang W, Zhu K, Li L, Lou Y, Wang H, Li Y, Lin H.
Zou Z, et al. Among authors: liu j, liu h.
Drug Deliv Transl Res. 2019 Feb;9(1):394-403. doi: 10.1007/s13346-018-0579-4.
Drug Deliv Transl Res. 2019.
PMID: 30136122