Liu L - Search Results

1

Changing the Apoptosis Pathway through Evolutionary Protein Design.

Shultis D, Mitra P, Huang X, Johnson J, Khattak NA, Gray F, Piper C, Czajka J, Hansen L, Wan B, Chinnaswamy K, Liu L, Wang M, Pan J, Stuckey J, Cierpicki T, Borchers CH, Wang S, Lei M, Zhang Y. Shultis D, et al. Among authors: liu l. J Mol Biol. 2019 Feb 15;431(4):825-841. doi: 10.1016/j.jmb.2018.12.016. Epub 2019 Jan 6. J Mol Biol. 2019. PMID: 30625288 Free PMC article.

2

Potent and selective small-molecule inhibitors of cIAP1/2 proteins reveal that the binding of Smac mimetics to XIAP BIR3 is not required for their effective induction of cell death in tumor cells.

Sun H, Lu J, Liu L, Yang CY, Wang S. Sun H, et al. Among authors: liu l. ACS Chem Biol. 2014 Apr 18;9(4):994-1002. doi: 10.1021/cb400889a. Epub 2014 Feb 12. ACS Chem Biol. 2014. PMID: 24521431 Free PMC article.

3

Case Study: discovery of inhibitors of the MDM2-p53 protein-protein interaction.

Liu L, Bernard D, Wang S. Liu L, et al. Methods Mol Biol. 2015;1278:567-85. doi: 10.1007/978-1-4939-2425-7_38. Methods Mol Biol. 2015. PMID: 25859977

4

Structure-Based Design of γ-Carboline Analogues as Potent and Specific BET Bromodomain Inhibitors.

Ran X, Zhao Y, Liu L, Bai L, Yang CY, Zhou B, Meagher JL, Chinnaswamy K, Stuckey JA, Wang S. Ran X, et al. Among authors: liu l. J Med Chem. 2015 Jun 25;58(12):4927-39. doi: 10.1021/acs.jmedchem.5b00613. Epub 2015 Jun 16. J Med Chem. 2015. PMID: 26080064 Free PMC article.

5

Design of the First-in-Class, Highly Potent Irreversible Inhibitor Targeting the Menin-MLL Protein-Protein Interaction.

Xu S, Aguilar A, Xu T, Zheng K, Huang L, Stuckey J, Chinnaswamy K, Bernard D, Fernández-Salas E, Liu L, Wang M, McEachern D, Przybranowski S, Foster C, Wang S. Xu S, et al. Among authors: liu l. Angew Chem Int Ed Engl. 2018 Feb 5;57(6):1601-1605. doi: 10.1002/anie.201711828. Epub 2018 Jan 15. Angew Chem Int Ed Engl. 2018. PMID: 29284071 Free article.

6

Targeting inhibitors of apoptosis proteins (IAPs) for new breast cancer therapeutics.

Wang S, Bai L, Lu J, Liu L, Yang CY, Sun H. Wang S, et al. Among authors: liu l. J Mammary Gland Biol Neoplasia. 2012 Dec;17(3-4):217-28. doi: 10.1007/s10911-012-9265-1. Epub 2012 Sep 29. J Mammary Gland Biol Neoplasia. 2012. PMID: 23054134 Free PMC article. Review.

7

Structure-based design of high-affinity macrocyclic peptidomimetics to block the menin-mixed lineage leukemia 1 (MLL1) protein-protein interaction.

Zhou H, Liu L, Huang J, Bernard D, Karatas H, Navarro A, Lei M, Wang S. Zhou H, et al. Among authors: liu l. J Med Chem. 2013 Feb 14;56(3):1113-23. doi: 10.1021/jm3015298. Epub 2013 Jan 17. J Med Chem. 2013. PMID: 23244744

8

Design of High-Affinity Stapled Peptides To Target the Repressor Activator Protein 1 (RAP1)/Telomeric Repeat-Binding Factor 2 (TRF2) Protein-Protein Interaction in the Shelterin Complex.

Ran X, Liu L, Yang CY, Lu J, Chen Y, Lei M, Wang S. Ran X, et al. Among authors: liu l. J Med Chem. 2016 Jan 14;59(1):328-34. doi: 10.1021/acs.jmedchem.5b01465. Epub 2015 Dec 29. J Med Chem. 2016. PMID: 26673461

9

Cyclopeptide Smac mimetics as antagonists of IAP proteins.

Sun H, Liu L, Lu J, Qiu S, Yang CY, Yi H, Wang S. Sun H, et al. Among authors: liu l. Bioorg Med Chem Lett. 2010 May 15;20(10):3043-6. doi: 10.1016/j.bmcl.2010.03.114. Bioorg Med Chem Lett. 2010. PMID: 20443226 Free PMC article.

10

Structure-based design of potent Bcl-2/Bcl-xL inhibitors with strong in vivo antitumor activity.

Zhou H, Aguilar A, Chen J, Bai L, Liu L, Meagher JL, Yang CY, McEachern D, Cong X, Stuckey JA, Wang S. Zhou H, et al. Among authors: liu l. J Med Chem. 2012 Jul 12;55(13):6149-61. doi: 10.1021/jm300608w. Epub 2012 Jul 2. J Med Chem. 2012. PMID: 22747598 Free PMC article.

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