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miRTarBase 2016: updates to the experimentally validated miRNA-target interactions database.
Chou CH, Chang NW, Shrestha S, Hsu SD, Lin YL, Lee WH, Yang CD, Hong HC, Wei TY, Tu SJ, Tsai TR, Ho SY, Jian TY, Wu HY, Chen PR, Lin NC, Huang HT, Yang TL, Pai CY, Tai CS, Chen WL, Huang CY, Liu CC, Weng SL, Liao KW, Hsu WL, Huang HD. Chou CH, et al. Nucleic Acids Res. 2016 Jan 4;44(D1):D239-47. doi: 10.1093/nar/gkv1258. Epub 2015 Nov 20. Nucleic Acids Res. 2016. PMID: 26590260 Free PMC article.
The latest update of the miRTarBase expanded it to identify systematically Argonaute-miRNA-RNA interactions from 138 crosslinking and immunoprecipitation sequencing (CLIP-seq) data sets that were generated by 21 independent studies. The database contains 4966 articles, 743 …
The latest update of the miRTarBase expanded it to identify systematically Argonaute-miRNA-RNA interactions from 138 crosslinking and immuno …
Mechanism of inactivation of gamma-aminobutyric acid aminotransferase by (1S,3S)-3-amino-4-difluoromethylene-1-cyclopentanoic acid (CPP-115).
Lee H, Doud EH, Wu R, Sanishvili R, Juncosa JI, Liu D, Kelleher NL, Silverman RB. Lee H, et al. J Am Chem Soc. 2015 Feb 25;137(7):2628-40. doi: 10.1021/ja512299n. Epub 2015 Feb 10. J Am Chem Soc. 2015. PMID: 25616005 Free PMC article.
Recently, CPP-115 was shown to have no adverse effects in a Phase I clinical trial. ...The partition ratio for CPP-115 with GABA-AT is about 2000, releasing cyclopentanone-2,4-dicarboxylate (22) and two other precursors of this compound (20 and 21). ...
Recently, CPP-115 was shown to have no adverse effects in a Phase I clinical trial. ...The partition ratio for CPP-115 with GA …
Quest for Missing Proteins: Update 2015 on Chromosome-Centric Human Proteome Project.
Horvatovich P, Lundberg EK, Chen YJ, Sung TY, He F, Nice EC, Goode RJ, Yu S, Ranganathan S, Baker MS, Domont GB, Velasquez E, Li D, Liu S, Wang Q, He QY, Menon R, Guan Y, Corrales FJ, Segura V, Casal JI, Pascual-Montano A, Albar JP, Fuentes M, Gonzalez-Gonzalez M, Diez P, Ibarrola N, Degano RM, Mohammed Y, Borchers CH, Urbani A, Soggiu A, Yamamoto T, Salekdeh GH, Archakov A, Ponomarenko E, Lisitsa A, Lichti CF, Mostovenko E, Kroes RA, Rezeli M, Végvári Á, Fehniger TE, Bischoff R, Vizcaíno JA, Deutsch EW, Lane L, Nilsson CL, Marko-Varga G, Omenn GS, Jeong SK, Lim JS, Paik YK, Hancock WS. Horvatovich P, et al. J Proteome Res. 2015 Sep 4;14(9):3415-31. doi: 10.1021/pr5013009. Epub 2015 Jul 23. J Proteome Res. 2015. PMID: 26076068 Free article.
Chemical constituents from branch of Fraxinus sieboldiana.
Lin S, Zhang YL, Liu MT, Zi JC, Gan ML, Song WX, Fan XN, Wang XN, Yang YC, Shi JG. Lin S, et al. Zhongguo Zhong Yao Za Zhi. 2015 Jul;40(13):2602-11. Zhongguo Zhong Yao Za Zhi. 2015. PMID: 26697686
Using a combination of various chromatographic techniques including column chromatography over silica gel, Sephadex LH-20, macroporous adsorbent resin, and reversed-phase HPLC, 115 compounds including diterpenes, sesquiterpenes, treterpenes, coumarins, lignans, fatty acid …
Using a combination of various chromatographic techniques including column chromatography over silica gel, Sephadex LH-20, macroporous adsor …
Structurally responsive oligonucleotide-based single-probe lateral-flow test for detection of miRNA-21 mimics.
Kor K, Turner AP, Zarei K, Atabati M, Beni V, Mak WC. Kor K, et al. Anal Bioanal Chem. 2016 Feb;408(5):1475-85. doi: 10.1007/s00216-015-9250-9. Epub 2015 Dec 23. Anal Bioanal Chem. 2016. PMID: 26700447
The response of the strip test was linear over the range 0.5 to 20 nM miRNA-21 (limit of detection of 115 pM) and showed good reproducibility (intra and inter CVs below 8%); furthermore, the assay was shown to be highly selective, discriminating other interference m …
The response of the strip test was linear over the range 0.5 to 20 nM miRNA-21 (limit of detection of 115 pM) and showed good …
Characterization of the multiple components of Acanthopanax Senticosus stem by ultra high performance liquid chromatography with quadrupole time-of-flight tandem mass spectrometry.
Sun H, Liu J, Zhang A, Zhang Y, Meng X, Han Y, Zhang Y, Wang X. Sun H, et al. J Sep Sci. 2016 Feb;39(3):496-502. doi: 10.1002/jssc.201500915. Epub 2015 Dec 29. J Sep Sci. 2016. PMID: 26632031
Of the 115 compounds in vitro, 54 were reported for first time, including sinapyl alcohol, sinapyl alcohol diglucoside, and 1-O-sinapoyl-beta-D-glucose. In the 41 compounds in vivo, 7 were prototype components and 34 were metabolites which were from 21 components of …
Of the 115 compounds in vitro, 54 were reported for first time, including sinapyl alcohol, sinapyl alcohol diglucoside, and 1-O-sinap …
[Quality standard study on Tibetan medicine Gentianae Szechenyii Flos].
Zong LL, Luo GF, Wu LH, Wang ZT, Liu HQ, Zhao DD. Zong LL, et al. Zhongguo Zhong Yao Za Zhi. 2015 May;40(10):1872-6. Zhongguo Zhong Yao Za Zhi. 2015. PMID: 26390640 Chinese.
The mass fractions of gentiournoside A, water content, ethanol-soluble extractives of 19 batches samples were varied in the ranges of 14.48-31.51 mg x g(-1), 11.25% -12.74% and 24.21% - 31.60%, respectively, and total ash was 4.64% - 6.12% detected from 10 batches samples. …
The mass fractions of gentiournoside A, water content, ethanol-soluble extractives of 19 batches samples were varied in the ranges of 14.48- …
Oxidation Dynamics of Methionine with Singlet Oxygen: Effects of Methionine Ionization and Microsolvation.
Liu F, Liu J. Liu F, et al. J Phys Chem B. 2015 Jun 25;119(25):8001-12. doi: 10.1021/acs.jpcb.5b03779. Epub 2015 Jun 8. J Phys Chem B. 2015. PMID: 26000762
The latter channel is similar to what was found in the reaction of dehydrated MetH(+) with (1)O2 (J. Phys. Chem. B 2011, 115, 2671). The reactions of hydrated protonated and deprotonated Met are all inhibited by Ecol, becoming negligible at Ecol 0.5 eV. ...
The latter channel is similar to what was found in the reaction of dehydrated MetH(+) with (1)O2 (J. Phys. Chem. B 2011, 115, 2671). …
18 results