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Constrained (l-)-S-adenosyl-l-homocysteine (SAH) analogues as DNA methyltransferase inhibitors.
Bioorg Med Chem Lett. 2009 May 15;19(10):2742-6. doi: 10.1016/j.bmcl.2009.03.132. Epub 2009 Mar 28.
Bioorg Med Chem Lett. 2009.
PMID: 19364644
SAR around (l)-S-adenosyl-l-homocysteine, an inhibitor of human DNA methyltransferase (DNMT) enzymes.
Saavedra OM, Isakovic L, Llewellyn DB, Zhan L, Bernstein N, Claridge S, Raeppel F, Vaisburg A, Elowe N, Petschner AJ, Rahil J, Beaulieu N, MacLeod AR, Delorme D, Besterman JM, Wahhab A.
Saavedra OM, et al. Among authors: llewellyn db.
Bioorg Med Chem Lett. 2009 May 15;19(10):2747-51. doi: 10.1016/j.bmcl.2009.03.113. Epub 2009 Mar 28.
Bioorg Med Chem Lett. 2009.
PMID: 19362833
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Discovery of a novel and potent series of thieno[3,2-b]pyridine-based inhibitors of c-Met and VEGFR2 tyrosine kinases.
Claridge S, Raeppel F, Granger MC, Bernstein N, Saavedra O, Zhan L, Llewellyn D, Wahhab A, Deziel R, Rahil J, Beaulieu N, Nguyen H, Dupont I, Barsalou A, Beaulieu C, Chute I, Gravel S, Robert MF, Lefebvre S, Dubay M, Pascal R, Gillespie J, Jin Z, Wang J, Besterman JM, MacLeod AR, Vaisburg A.
Claridge S, et al.
Bioorg Med Chem Lett. 2008 May 1;18(9):2793-8. doi: 10.1016/j.bmcl.2008.04.009. Epub 2008 Apr 9.
Bioorg Med Chem Lett. 2008.
PMID: 18434145
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A novel example of chiral counteranion induced enantioselective metal catalysis: the importance of ion-pairing in copper-catalyzed olefin aziridination and cyclopropanation.
Llewellyn DB, Adamson D, Arndtsen BA.
Llewellyn DB, et al.
Org Lett. 2000 Dec 28;2(26):4165-8. doi: 10.1021/ol000303y.
Org Lett. 2000.
PMID: 11150190
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Biochemical characterization of the suberization-associated anionic peroxidase of potato.
Bernards MA, Fleming WD, Llewellyn DB, Priefer R, Yang X, Sabatino A, Plourde GL.
Bernards MA, et al. Among authors: llewellyn db.
Plant Physiol. 1999 Sep;121(1):135-46. doi: 10.1104/pp.121.1.135.
Plant Physiol. 1999.
PMID: 10482668
Free PMC article.
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