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Structure-Activity Relationship and Crystallographic Studies on 4-Hydroxypyrimidine HIF Prolyl Hydroxylase Domain Inhibitors.
Holt-Martyn JP, Chowdhury R, Tumber A, Yeh TL, Abboud MI, Lippl K, Lohans CT, Langley GW, Figg W Jr, McDonough MA, Pugh CW, Ratcliffe PJ, Schofield CJ. Holt-Martyn JP, et al. Among authors: lohans ct. ChemMedChem. 2020 Feb 5;15(3):270-273. doi: 10.1002/cmdc.201900557. Epub 2019 Dec 3. ChemMedChem. 2020. PMID: 31751494 Free PMC article.
Molecular and cellular mechanisms of HIF prolyl hydroxylase inhibitors in clinical trials.
Yeh TL, Leissing TM, Abboud MI, Thinnes CC, Atasoylu O, Holt-Martyn JP, Zhang D, Tumber A, Lippl K, Lohans CT, Leung IKH, Morcrette H, Clifton IJ, Claridge TDW, Kawamura A, Flashman E, Lu X, Ratcliffe PJ, Chowdhury R, Pugh CW, Schofield CJ. Yeh TL, et al. Among authors: lohans ct. Chem Sci. 2017 Nov 1;8(11):7651-7668. doi: 10.1039/c7sc02103h. Epub 2017 Sep 11. Chem Sci. 2017. PMID: 29435217 Free PMC article.
Inhibition of a viral prolyl hydroxylase.
Langley GW, Abboud MI, Lohans CT, Schofield CJ. Langley GW, et al. Among authors: lohans ct. Bioorg Med Chem. 2019 Jun 15;27(12):2405-2412. doi: 10.1016/j.bmc.2019.01.018. Epub 2019 Jan 23. Bioorg Med Chem. 2019. PMID: 30737136
Studies on the inhibition of AmpC and other β-lactamases by cyclic boronates.
Cahill ST, Tyrrell JM, Navratilova IH, Calvopiña K, Robinson SW, Lohans CT, McDonough MA, Cain R, Fishwick CWG, Avison MB, Walsh TR, Schofield CJ, Brem J. Cahill ST, et al. Among authors: lohans ct. Biochim Biophys Acta Gen Subj. 2019 Apr;1863(4):742-748. doi: 10.1016/j.bbagen.2019.02.004. Epub 2019 Feb 7. Biochim Biophys Acta Gen Subj. 2019. PMID: 30738906 Free article.
52 results