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Depletion of LONP2 unmasks differential requirements for peroxisomal function between cell types and in cholesterol metabolism.
Yamashita A, Ignatenko O, Nguyen M, Lambert R, Watt K, Daneault C, Robillard-Frayne I, Topisirovic I, Rosiers CD, McBride HM. Yamashita A, et al. Biol Direct. 2023 Sep 22;18(1):60. doi: 10.1186/s13062-023-00416-3. Biol Direct. 2023. PMID: 37736739 Free PMC article.
Herein, we report the cellular responses to peroxisomal proteotoxic stress upon silencing the peroxisomal protease/chaperone LONP2. Depletion of LONP2 triggered the accumulation of its substrate TYSND1 protease, while the overall expression of peroxisomal proteins, …
Herein, we report the cellular responses to peroxisomal proteotoxic stress upon silencing the peroxisomal protease/chaperone LONP2. D …
Role of LONP2 in head and neck squamous cell carcinoma.
Cui X, Zhang Y, Zhang L, Liu J, Bai Y, Cui Y, Wang B, Zhang S, Li X. Cui X, et al. Gene. 2023 Jan 30;851:147033. doi: 10.1016/j.gene.2022.147033. Epub 2022 Nov 5. Gene. 2023. PMID: 36347334
Ectopic overexpressed LONP2 enhanced HNSCC cell growth and migration. Nevertheless, LONP2 silencing suppressed tumor growth in vitro and in vivo. ...Furthermore, knockdown of PLS3 inhibited the cell proliferation induced by LONP2 overexpression. In conclusion …
Ectopic overexpressed LONP2 enhanced HNSCC cell growth and migration. Nevertheless, LONP2 silencing suppressed tumor growth in …
The peroxisomal Lon protease LonP2 in aging and disease: functions and comparisons with mitochondrial Lon protease LonP1.
Pomatto LC, Raynes R, Davies KJ. Pomatto LC, et al. Biol Rev Camb Philos Soc. 2017 May;92(2):739-753. doi: 10.1111/brv.12253. Epub 2016 Feb 8. Biol Rev Camb Philos Soc. 2017. PMID: 26852705 Free PMC article. Review.
While the importance of mitochondrial Lon (LonP1) in relation to oxidative stress and aging has been established, little is known regarding the role of LonP2 and aging-related changes in the peroxisome. Recently, peroxisome dysfunction has been associated with aging-relate …
While the importance of mitochondrial Lon (LonP1) in relation to oxidative stress and aging has been established, little is known regarding …
Lon Peptidase 2, Peroxisomal (LONP2) Contributes to Cervical Carcinogenesis via Oxidative Stress.
Wu W, Liu F, Wu K, Chen Y, Wu H, Dai G, Zhang W. Wu W, et al. Med Sci Monit. 2018 Mar 4;24:1310-1320. doi: 10.12659/msm.908966. Med Sci Monit. 2018. PMID: 29502128 Free PMC article.
MATERIAL AND METHODS Oncomine databases and tissue microarrays, initially using immunohistochemistry, were used to analyze LONP2 expression in cervical cancer. In order to uncover the biologic functions and mechanism(s) underlying LONP2 in cervical tumorigenesis, we …
MATERIAL AND METHODS Oncomine databases and tissue microarrays, initially using immunohistochemistry, were used to analyze LONP2 expr …
Curcumin Alleviates Oxygen-Glucose-Deprivation/Reperfusion-Induced Oxidative Damage by Regulating miR-1287-5p/LONP2 Axis in SH-SY5Y Cells.
Zhang T, Chen X, Qu Y, Ding Y. Zhang T, et al. Anal Cell Pathol (Amst). 2021 Sep 18;2021:5548706. doi: 10.1155/2021/5548706. eCollection 2021. Anal Cell Pathol (Amst). 2021. PMID: 34589382 Free PMC article.
Additionally, we predicted that Lon Peptidase 2, Peroxisomal (LONP2), which is involved in oxidative stress regulation, is targeted by miR-1287-5p. ...To mimic ischemia/reperfusion damage environment, SH-SY5Y cells were subjected to oxygen-glucose-deprivation/reperfusion ( …
Additionally, we predicted that Lon Peptidase 2, Peroxisomal (LONP2), which is involved in oxidative stress regulation, is targeted b …
Redox Regulation of Homeostasis and Proteostasis in Peroxisomes.
Walker CL, Pomatto LCD, Tripathi DN, Davies KJA. Walker CL, et al. Physiol Rev. 2018 Jan 1;98(1):89-115. doi: 10.1152/physrev.00033.2016. Physiol Rev. 2018. PMID: 29167332 Free PMC article. Review.
Peroxisomal proteins are also subject to oxidative modification and inactivation by the reactive oxygen and nitrogen species they generate, but the peroxisomal LonP2 protease can selectively remove such oxidatively damaged proteins, thus prolonging the useful lifespan of t …
Peroxisomal proteins are also subject to oxidative modification and inactivation by the reactive oxygen and nitrogen species they generate, …
Reduced peroxisomal import triggers peroxisomal retrograde signaling.
Rackles E, Witting M, Forné I, Zhang X, Zacherl J, Schrott S, Fischer C, Ewbank JJ, Osman C, Imhof A, Rolland SG. Rackles E, et al. Cell Rep. 2021 Jan 19;34(3):108653. doi: 10.1016/j.celrep.2020.108653. Cell Rep. 2021. PMID: 33472070 Free article.
Specifically, we show that peroxisomal import stress caused by knockdown of the peroxisomal matrix import receptor prx-5/PEX5 triggers NHR-49/peroxisome proliferator activated receptor alpha (PPARalpha)- and MDT-15/MED15-dependent upregulation of the peroxisomal Lon protease lonp …
Specifically, we show that peroxisomal import stress caused by knockdown of the peroxisomal matrix import receptor prx-5/PEX5 triggers NHR-4 …
DNA methylation as a potential mediator of the association between indoor air pollution and neurodevelopmental delay in a South African birth cohort.
Feil D, Abrishamcar S, Christensen GM, Vanker A, Koen N, Kilanowski A, Hoffman N, Wedderburn CJ, Donald KA, Kobor MS, Zar HJ, Stein DJ, Hüls A. Feil D, et al. Clin Epigenetics. 2023 Feb 28;15(1):31. doi: 10.1186/s13148-023-01444-6. Clin Epigenetics. 2023. PMID: 36855151 Free PMC article.
DYRK1A and several genes that our CpG sites mapped to, including CNKSR1, IPO13, IFNGR1, LONP2, and CDH1, are associated with biological pathways implicated in cognitive neurodevelopment and three of our identified CpG sites (cg23560546 [DAPL1], cg22572779 [C6orf218], cg150 …
DYRK1A and several genes that our CpG sites mapped to, including CNKSR1, IPO13, IFNGR1, LONP2, and CDH1, are associated with biologic …
Appropriate leucine supplementation promotes glucose metabolism and enhances energy homeostasis in juvenile crucian carp (Carassius auratus gibelio var. CAS III).
Miao L, Zhang Y, Lin Y, Liu B, Ge X. Miao L, et al. Comp Biochem Physiol Part D Genomics Proteomics. 2021 Dec;40:100907. doi: 10.1016/j.cbd.2021.100907. Epub 2021 Aug 26. Comp Biochem Physiol Part D Genomics Proteomics. 2021. PMID: 34481144
Moreover, the mRNA expression levels of acyl-CoA synthetase long chain family member 5 (ACSL5), choline kinase beta (CHKB), cryptochrome-1 (CRY1), lon protease homolog 2, peroxisomal isoform X2 (LONP2), lipin 1 (LPIN1), membrane bound O-acyltransferase domain containing 2 …
Moreover, the mRNA expression levels of acyl-CoA synthetase long chain family member 5 (ACSL5), choline kinase beta (CHKB), cryptochrome-1 ( …
18 results