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Plasmodium falciparum full life cycle and Plasmodium ovale liver stages in humanized mice.
Soulard V, Bosson-Vanga H, Lorthiois A, Roucher C, Franetich JF, Zanghi G, Bordessoulles M, Tefit M, Thellier M, Morosan S, Le Naour G, Capron F, Suemizu H, Snounou G, Moreno-Sabater A, Mazier D. Soulard V, et al. Among authors: lorthiois a. Nat Commun. 2015 Jul 24;6:7690. doi: 10.1038/ncomms8690. Nat Commun. 2015. PMID: 26205537 Free PMC article.
Persistence and activation of malaria hypnozoites in long-term primary hepatocyte cultures.
Dembélé L, Franetich JF, Lorthiois A, Gego A, Zeeman AM, Kocken CH, Le Grand R, Dereuddre-Bosquet N, van Gemert GJ, Sauerwein R, Vaillant JC, Hannoun L, Fuchter MJ, Diagana TT, Malmquist NA, Scherf A, Snounou G, Mazier D. Dembélé L, et al. Among authors: lorthiois a. Nat Med. 2014 Mar;20(3):307-12. doi: 10.1038/nm.3461. Epub 2014 Feb 9. Nat Med. 2014. PMID: 24509527
A genetically attenuated malaria vaccine candidate based on P. falciparum b9/slarp gene-deficient sporozoites.
van Schaijk BC, Ploemen IH, Annoura T, Vos MW, Foquet L, van Gemert GJ, Chevalley-Maurel S, van de Vegte-Bolmer M, Sajid M, Franetich JF, Lorthiois A, Leroux-Roels G, Meuleman P, Hermsen CC, Mazier D, Hoffman SL, Janse CJ, Khan SM, Sauerwein RW. van Schaijk BC, et al. Among authors: lorthiois a. Elife. 2014 Nov 19;3:e03582. doi: 10.7554/eLife.03582. Elife. 2014. PMID: 25407681 Free PMC article.
Discovery of new thienopyrimidinone derivatives displaying antimalarial properties toward both erythrocytic and hepatic stages of Plasmodium.
Cohen A, Suzanne P, Lancelot JC, Verhaeghe P, Lesnard A, Basmaciyan L, Hutter S, Laget M, Dumètre A, Paloque L, Deharo E, Crozet MD, Rathelot P, Dallemagne P, Lorthiois A, Sibley CH, Vanelle P, Valentin A, Mazier D, Rault S, Azas N. Cohen A, et al. Among authors: lorthiois a. Eur J Med Chem. 2015 May 5;95:16-28. doi: 10.1016/j.ejmech.2015.03.011. Epub 2015 Mar 10. Eur J Med Chem. 2015. PMID: 25791675
Infectivity of Plasmodium falciparum sporozoites determines emerging parasitemia in infected volunteers.
McCall MBB, Wammes LJ, Langenberg MCC, van Gemert GJ, Walk J, Hermsen CC, Graumans W, Koelewijn R, Franetich JF, Chishimba S, Gerdsen M, Lorthiois A, van de Vegte M, Mazier D, Bijker EM, van Hellemond JJ, van Genderen PJJ, Sauerwein RW. McCall MBB, et al. Among authors: lorthiois a. Sci Transl Med. 2017 Jun 21;9(395):eaag2490. doi: 10.1126/scitranslmed.aag2490. Sci Transl Med. 2017. PMID: 28637923
Plasmodium falciparum sexual parasites develop in human erythroblasts and affect erythropoiesis.
Neveu G, Richard C, Dupuy F, Behera P, Volpe F, Subramani PA, Marcel-Zerrougui B, Vallin P, Andrieu M, Minz AM, Azar N, Martins RM, Lorthiois A, Gazeau F, Lopez-Rubio JJ, Mazier D, Silva AKA, Satpathi S, Wassmer SC, Verdier F, Lavazec C. Neveu G, et al. Among authors: lorthiois a. Blood. 2020 Sep 17;136(12):1381-1393. doi: 10.1182/blood.2019004746. Blood. 2020. PMID: 32589714 Free PMC article.
The Host Protein Aquaporin-9 is Required for Efficient Plasmodium falciparum Sporozoite Entry into Human Hepatocytes.
Amanzougaghene N, Tajeri S, Yalaoui S, Lorthiois A, Soulard V, Gego A, Rametti A, Risco-Castillo V, Moreno A, Tefit M, van Gemert GJ, Sauerwein RW, Vaillant JC, Ravassard P, Pérignon JL, Froissard P, Mazier D, Franetich JF. Amanzougaghene N, et al. Among authors: lorthiois a. Front Cell Infect Microbiol. 2021 Jun 29;11:704662. doi: 10.3389/fcimb.2021.704662. eCollection 2021. Front Cell Infect Microbiol. 2021. PMID: 34268141 Free PMC article.
18 results