Lotz GP - Search Results

1

Identifying polyglutamine protein species in situ that best predict neurodegeneration.

Miller J, Arrasate M, Brooks E, Libeu CP, Legleiter J, Hatters D, Curtis J, Cheung K, Krishnan P, Mitra S, Widjaja K, Shaby BA, Lotz GP, Newhouse Y, Mitchell EJ, Osmand A, Gray M, Thulasiramin V, Saudou F, Segal M, Yang XW, Masliah E, Thompson LM, Muchowski PJ, Weisgraber KH, Finkbeiner S. Miller J, et al. Among authors: lotz gp. Nat Chem Biol. 2011 Oct 30;7(12):925-34. doi: 10.1038/nchembio.694. Nat Chem Biol. 2011. PMID: 22037470 Free PMC article.

2

Monoclonal antibodies recognize distinct conformational epitopes formed by polyglutamine in a mutant huntingtin fragment.

Legleiter J, Lotz GP, Miller J, Ko J, Ng C, Williams GL, Finkbeiner S, Patterson PH, Muchowski PJ. Legleiter J, et al. Among authors: lotz gp. J Biol Chem. 2009 Aug 7;284(32):21647-58. doi: 10.1074/jbc.M109.016923. Epub 2009 Jun 2. J Biol Chem. 2009. PMID: 19491400 Free PMC article.

3

Mutant huntingtin fragments form oligomers in a polyglutamine length-dependent manner in vitro and in vivo.

Legleiter J, Mitchell E, Lotz GP, Sapp E, Ng C, DiFiglia M, Thompson LM, Muchowski PJ. Legleiter J, et al. Among authors: lotz gp. J Biol Chem. 2010 May 7;285(19):14777-90. doi: 10.1074/jbc.M109.093708. Epub 2010 Mar 10. J Biol Chem. 2010. PMID: 20220138 Free PMC article.

4

Hsp70 and Hsp40 functionally interact with soluble mutant huntingtin oligomers in a classic ATP-dependent reaction cycle.

Lotz GP, Legleiter J, Aron R, Mitchell EJ, Huang SY, Ng C, Glabe C, Thompson LM, Muchowski PJ. Lotz GP, et al. J Biol Chem. 2010 Dec 3;285(49):38183-93. doi: 10.1074/jbc.M110.160218. Epub 2010 Sep 23. J Biol Chem. 2010. PMID: 20864533 Free PMC article.

5

The role of amyloidogenic protein oligomerization in neurodegenerative disease.

Lotz GP, Legleiter J. Lotz GP, et al. J Mol Med (Berl). 2013 Jun;91(6):653-64. doi: 10.1007/s00109-013-1025-1. Epub 2013 Mar 27. J Mol Med (Berl). 2013. PMID: 23529761 Review.

6

Expanded polyglutamine-binding peptoid as a novel therapeutic agent for treatment of Huntington's disease.

Chen X, Wu J, Luo Y, Liang X, Supnet C, Kim MW, Lotz GP, Yang G, Muchowski PJ, Kodadek T, Bezprozvanny I. Chen X, et al. Among authors: lotz gp. Chem Biol. 2011 Sep 23;18(9):1113-25. doi: 10.1016/j.chembiol.2011.06.010. Chem Biol. 2011. PMID: 21944750 Free PMC article.

7

Methylene blue modulates huntingtin aggregation intermediates and is protective in Huntington's disease models.

Sontag EM, Lotz GP, Agrawal N, Tran A, Aron R, Yang G, Necula M, Lau A, Finkbeiner S, Glabe C, Marsh JL, Muchowski PJ, Thompson LM. Sontag EM, et al. Among authors: lotz gp. J Neurosci. 2012 Aug 8;32(32):11109-19. doi: 10.1523/JNEUROSCI.0895-12.2012. J Neurosci. 2012. PMID: 22875942 Free PMC article.

8

Detection of Mutant Huntingtin Aggregation Conformers and Modulation of SDS-Soluble Fibrillar Oligomers by Small Molecules.

Sontag EM, Lotz GP, Yang G, Sontag CJ, Cummings BJ, Glabe CG, Muchowski PJ, Thompson LM. Sontag EM, et al. Among authors: lotz gp. J Huntingtons Dis. 2012;1(1):119-32. doi: 10.3233/JHD-2012-129004. J Huntingtons Dis. 2012. PMID: 24086178 Free PMC article.

9

Loss of Hsp70 exacerbates pathogenesis but not levels of fibrillar aggregates in a mouse model of Huntington's disease.

Wacker JL, Huang SY, Steele AD, Aron R, Lotz GP, Nguyen Q, Giorgini F, Roberson ED, Lindquist S, Masliah E, Muchowski PJ. Wacker JL, et al. Among authors: lotz gp. J Neurosci. 2009 Jul 15;29(28):9104-14. doi: 10.1523/JNEUROSCI.2250-09.2009. J Neurosci. 2009. PMID: 19605647 Free PMC article.

10

Reversing EphB2 depletion rescues cognitive functions in Alzheimer model.

Cissé M, Halabisky B, Harris J, Devidze N, Dubal DB, Sun B, Orr A, Lotz G, Kim DH, Hamto P, Ho K, Yu GQ, Mucke L. Cissé M, et al. Nature. 2011 Jan 6;469(7328):47-52. doi: 10.1038/nature09635. Epub 2010 Nov 28. Nature. 2011. PMID: 21113149 Free PMC article.

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