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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1973 3
1974 3
1975 3
1976 2
1977 2
1978 4
1979 2
1980 3
1981 2
1982 4
1983 10
1984 5
1985 10
1986 5
1987 6
1988 16
1989 13
1990 23
1991 20
1992 31
1993 25
1994 39
1995 43
1996 54
1997 54
1998 73
1999 76
2000 116
2001 145
2002 149
2003 188
2004 247
2005 272
2006 287
2007 341
2008 347
2009 373
2010 430
2011 443
2012 493
2013 559
2014 551
2015 502
2016 538
2017 571
2018 555
2019 588
2020 666
2021 695
2022 677
2023 666
2024 325

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9,966 results

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Page 1
LOX-1, OxLDL, and atherosclerosis.
Pirillo A, Norata GD, Catapano AL. Pirillo A, et al. Mediators Inflamm. 2013;2013:152786. doi: 10.1155/2013/152786. Epub 2013 Jul 10. Mediators Inflamm. 2013. PMID: 23935243 Free PMC article. Review.
The key contribution of LOX-1 to the atherogenic process has been confirmed in animal models; LOX-1 knockout mice exhibit reduced intima thickness and inflammation and increased expression of protective factors; on the contrary, LOX-1 overexpressing mice pres …
The key contribution of LOX-1 to the atherogenic process has been confirmed in animal models; LOX-1 knockout mice exhibit redu …
Role of Ox-LDL and LOX-1 in Atherogenesis.
Kattoor AJ, Kanuri SH, Mehta JL. Kattoor AJ, et al. Curr Med Chem. 2019;26(9):1693-1700. doi: 10.2174/0929867325666180508100950. Curr Med Chem. 2019. PMID: 29737246 Review.
They also stimulate generation of metalloproteinases and contribute to plaque instability and thrombosis. Drugs that modulate LOX-1 are desirable targets against atherosclerosis. Many naturally occurring compounds have been shown to modulate LOX-1 expression and ath …
They also stimulate generation of metalloproteinases and contribute to plaque instability and thrombosis. Drugs that modulate LOX-1 a …
LOX-1 and atherosclerotic-related diseases.
Jin P, Cong S. Jin P, et al. Clin Chim Acta. 2019 Apr;491:24-29. doi: 10.1016/j.cca.2019.01.006. Epub 2019 Jan 9. Clin Chim Acta. 2019. PMID: 30639239 Review.
Under pathological conditions, the extracellular domain of membrane bound LOX-1 can be largely proteolytically cleaved into a soluble form (sLOX-1), which is proportional and linked to the LOX-1 expression level. ...Genetic polymorphisms of LOX-1 have been in …
Under pathological conditions, the extracellular domain of membrane bound LOX-1 can be largely proteolytically cleaved into a soluble …
LOX-1: Regulation, Signaling and Its Role in Atherosclerosis.
Kattoor AJ, Goel A, Mehta JL. Kattoor AJ, et al. Antioxidants (Basel). 2019 Jul 11;8(7):218. doi: 10.3390/antiox8070218. Antioxidants (Basel). 2019. PMID: 31336709 Free PMC article. Review.
LOX-1 gene deletion in mice and anti-LOX-1 therapy has been shown to decrease inflammation, oxidative stress and atherosclerosis. LOX-1 deletion also results in damage from ischemia, making LOX-1 a promising target of therapy for atherosclerosis and re …
LOX-1 gene deletion in mice and anti-LOX-1 therapy has been shown to decrease inflammation, oxidative stress and atheroscleros …
The structural basis of effective LOX-1 inhibition.
Kore RA, Bagchi AK, Varughese KI, Mehta JL. Kore RA, et al. Future Med Chem. 2022 May;14(10):731-743. doi: 10.4155/fmc-2022-0011. Epub 2022 Apr 25. Future Med Chem. 2022. PMID: 35466695 Review.
Increased expression of LOX-1 precipitates pathological disorders during the aging process. ...In this review, we shed light on the presently studied and developed novel LOX-1 inhibitors that may have potential for treatment of diseases characterized by LOX-1 …
Increased expression of LOX-1 precipitates pathological disorders during the aging process. ...In this review, we shed light on the p …
LOX-1 in Atherosclerosis and Myocardial Ischemia: Biology, Genetics, and Modulation.
Pothineni NVK, Karathanasis SK, Ding Z, Arulandu A, Varughese KI, Mehta JL. Pothineni NVK, et al. J Am Coll Cardiol. 2017 Jun 6;69(22):2759-2768. doi: 10.1016/j.jacc.2017.04.010. J Am Coll Cardiol. 2017. PMID: 28571642 Free article. Review.
As evidence supporting the vital role of LOX-1 in atherogenesis keeps accumulating, there is growing interest in LOX-1 as a potential therapeutic target. This review discusses the discovery and genetics of LOX-1; describes existing evidence supporting the rol …
As evidence supporting the vital role of LOX-1 in atherogenesis keeps accumulating, there is growing interest in LOX-1 as a po …
Targeting LOX-1 in atherosclerosis and vasculopathy: current knowledge and future perspectives.
Tian K, Ogura S, Little PJ, Xu SW, Sawamura T. Tian K, et al. Ann N Y Acad Sci. 2019 May;1443(1):34-53. doi: 10.1111/nyas.13984. Epub 2018 Nov 1. Ann N Y Acad Sci. 2019. PMID: 30381837 Review.
Several genetic variants of LOX-1 are associated with the risk and severity of coronary artery disease. ...In addition, LOX-1 can be cleaved to generate soluble LOX-1 (sLOX-1), which is a useful diagnostic and prognostic marker for atherosclerosis-related dis …
Several genetic variants of LOX-1 are associated with the risk and severity of coronary artery disease. ...In addition, LOX-1 …
Lysyl Oxidase (LOX): Functional Contributions to Signaling Pathways.
Laczko R, Csiszar K. Laczko R, et al. Biomolecules. 2020 Jul 22;10(8):1093. doi: 10.3390/biom10081093. Biomolecules. 2020. PMID: 32708046 Free PMC article. Review.
Most of these conditions involve mechanisms with complex cell and tissue type-specific interactions of LOX with signaling pathways, not only as a regulatory target, but also as an active player, including LOX-mediated alterations of cell surface receptor functions a …
Most of these conditions involve mechanisms with complex cell and tissue type-specific interactions of LOX with signaling pathways, n …
Phosphorylation of 5-LOX: The Potential Set-point of Inflammation.
He Z, Tao D, Xiong J, Lou F, Zhang J, Chen J, Dai W, Sun J, Wang Y. He Z, et al. Neurochem Res. 2020 Oct;45(10):2245-2257. doi: 10.1007/s11064-020-03090-3. Epub 2020 Jul 15. Neurochem Res. 2020. PMID: 32671628 Review.
Surprisingly, phosphorylation of 5-LOX reveals great significance in regulating the subcellular localization of 5-LOX, which has proven to be an important mechanism underlying the enzymatic activities of 5-LOX. ...The present review intends to shed more light …
Surprisingly, phosphorylation of 5-LOX reveals great significance in regulating the subcellular localization of 5-LOX, which h …
LOX-1: a male hormone-regulated scavenger receptor for atherosclerosis.
Gao S, Geng YJ. Gao S, et al. Vascul Pharmacol. 2013 Nov-Dec;59(5-6):138-43. doi: 10.1016/j.vph.2013.10.003. Epub 2013 Oct 21. Vascul Pharmacol. 2013. PMID: 24157503 Review.
Exposure to ox-LDL induces LOX-1 expression and LOX-1-dependent biological activities, such as activation of NF-kappaB, a nuclear factor important for signal transduction in inflammation. Accumulating evidence indicates that male hormones may regulate expression of …
Exposure to ox-LDL induces LOX-1 expression and LOX-1-dependent biological activities, such as activation of NF-kappaB, a nucl …
9,966 results