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Autophagy is required for endothelial cell alignment and atheroprotection under physiological blood flow.
Vion AC, Kheloufi M, Hammoutene A, Poisson J, Lasselin J, Devue C, Pic I, Dupont N, Busse J, Stark K, Lafaurie-Janvore J, Barakat AI, Loyer X, Souyri M, Viollet B, Julia P, Tedgui A, Codogno P, Boulanger CM, Rautou PE. Vion AC, et al. Among authors: loyer x. Proc Natl Acad Sci U S A. 2017 Oct 10;114(41):E8675-E8684. doi: 10.1073/pnas.1702223114. Epub 2017 Sep 25. Proc Natl Acad Sci U S A. 2017. PMID: 28973855 Free PMC article.
Endothelial autophagic flux hampers atherosclerotic lesion development.
Kheloufi M, Vion AC, Hammoutene A, Poisson J, Lasselin J, Devue C, Pic I, Dupont N, Busse J, Stark K, Lafaurie-Janvore J, Barakat AI, Loyer X, Souyri M, Viollet B, Julia P, Tedgui A, Codogno P, Boulanger CM, Rautou PE. Kheloufi M, et al. Among authors: loyer x. Autophagy. 2018;14(1):173-175. doi: 10.1080/15548627.2017.1395114. Epub 2018 Jan 29. Autophagy. 2018. PMID: 29157095 Free PMC article.
A defect in endothelial autophagy occurs in patients with non-alcoholic steatohepatitis and promotes inflammation and fibrosis.
Hammoutene A, Biquard L, Lasselin J, Kheloufi M, Tanguy M, Vion AC, Mérian J, Colnot N, Loyer X, Tedgui A, Codogno P, Lotersztajn S, Paradis V, Boulanger CM, Rautou PE. Hammoutene A, et al. Among authors: loyer x. J Hepatol. 2020 Mar;72(3):528-538. doi: 10.1016/j.jhep.2019.10.028. Epub 2019 Nov 11. J Hepatol. 2020. PMID: 31726115
Shear stress regulates endothelial microparticle release.
Vion AC, Ramkhelawon B, Loyer X, Chironi G, Devue C, Loirand G, Tedgui A, Lehoux S, Boulanger CM. Vion AC, et al. Among authors: loyer x. Circ Res. 2013 May 10;112(10):1323-33. doi: 10.1161/CIRCRESAHA.112.300818. Epub 2013 Mar 27. Circ Res. 2013. PMID: 23536307
MicroRNAs as therapeutic targets in atherosclerosis.
Loyer X, Mallat Z, Boulanger CM, Tedgui A. Loyer X, et al. Expert Opin Ther Targets. 2015 Apr;19(4):489-96. doi: 10.1517/14728222.2014.989835. Epub 2014 Dec 3. Expert Opin Ther Targets. 2015. PMID: 25464904 Review.
Extracellular vesicles in coronary artery disease.
Boulanger CM, Loyer X, Rautou PE, Amabile N. Boulanger CM, et al. Among authors: loyer x. Nat Rev Cardiol. 2017 May;14(5):259-272. doi: 10.1038/nrcardio.2017.7. Epub 2017 Feb 2. Nat Rev Cardiol. 2017. PMID: 28150804 Review.
Liver microRNA-21 is overexpressed in non-alcoholic steatohepatitis and contributes to the disease in experimental models by inhibiting PPARα expression.
Loyer X, Paradis V, Hénique C, Vion AC, Colnot N, Guerin CL, Devue C, On S, Scetbun J, Romain M, Paul JL, Rothenberg ME, Marcellin P, Durand F, Bedossa P, Prip-Buus C, Baugé E, Staels B, Boulanger CM, Tedgui A, Rautou PE. Loyer X, et al. Gut. 2016 Nov;65(11):1882-1894. doi: 10.1136/gutjnl-2014-308883. Epub 2015 Sep 3. Gut. 2016. PMID: 26338827 Free PMC article.
54 results