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Year Number of Results
2006 2
2007 3
2008 2
2010 1
2012 1
2014 2
2016 1
2017 2
2018 1
2019 2
2020 4
2021 2
2022 3
2023 1
2024 0

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LRCH1 deficiency enhances LAT signalosome formation and CD8(+) T cell responses against tumors and pathogens.
Liu C, Xu X, Han L, Wan X, Zheng L, Li C, Liao Z, Xiao J, Zhong R, Zheng X, Wang Q, Li Z, Chen H, Wei B, Wang H. Liu C, et al. Proc Natl Acad Sci U S A. 2020 Aug 11;117(32):19388-19398. doi: 10.1073/pnas.2000970117. Epub 2020 Jul 29. Proc Natl Acad Sci U S A. 2020. PMID: 32727906 Free PMC article.
Adoptive transfer of Lrch1(-/-) CD8(+) CTLs leads to increased B16-MO5 tumor clearance in vivo. ...These findings suggest LRCH1 as a potential translational target to improve T cell immunotherapy against infection and tumors....
Adoptive transfer of Lrch1(-/-) CD8(+) CTLs leads to increased B16-MO5 tumor clearance in vivo. ...These findings suggest LRCH1 …
LRCH1 suppresses migration of CD4(+) T cells and refers to disease activity in ulcerative colitis.
Wang Y, Zhang H, He H, Ai K, Yu W, Xiao X, Qin Y, Zhang L, Xiong H, Zhou G. Wang Y, et al. Int J Med Sci. 2020 Feb 17;17(5):599-608. doi: 10.7150/ijms.39106. eCollection 2020. Int J Med Sci. 2020. PMID: 32210709 Free PMC article.
Peripheral blood CD4(+) T cells were transfected with lentivirus-expressing LRCH1 (LV-LRCH1) or LV-sh-LRCH1, and cytokine expression was determined by using flow cytometry, quantitative RT-PCR and ELISA. ...Moreover, LRCH1 inhibited migratory capacity …
Peripheral blood CD4(+) T cells were transfected with lentivirus-expressing LRCH1 (LV-LRCH1) or LV-sh-LRCH1, and cytoki …
LRCH1 polymorphisms linked to delayed encephalopathy after acute carbon monoxide poisoning identified by GWAS analysis followed by Sequenom MassARRAY validation.
Gu J, Zeng J, Wang X, Gu X, Zhang X, Zhang P, Zhang F, Han Y, Han Y, Zhang H, Li W, Gu R. Gu J, et al. BMC Med Genet. 2019 Dec 16;20(1):197. doi: 10.1186/s12881-019-0931-7. BMC Med Genet. 2019. PMID: 31842790 Free PMC article.
The LRCH1 rs2236592 polymorphism was susceptible to DEACMP only under the dominant model (TT/TC + CC, OR = 1.616, 95% CI: 1.092-2.390, P = 0.015784). ...CONCLUSIONS: We found a significant association between the four LRCH1 polymorphisms and DEACMP. The allelic A of …
The LRCH1 rs2236592 polymorphism was susceptible to DEACMP only under the dominant model (TT/TC + CC, OR = 1.616, 95% CI: 1.092-2.390 …
LRCH1 interferes with DOCK8-Cdc42-induced T cell migration and ameliorates experimental autoimmune encephalomyelitis.
Xu X, Han L, Zhao G, Xue S, Gao Y, Xiao J, Zhang S, Chen P, Wu ZY, Ding J, Hu R, Wei B, Wang H. Xu X, et al. J Exp Med. 2017 Jan;214(1):209-226. doi: 10.1084/jem.20160068. J Exp Med. 2017. PMID: 28028151 Free PMC article.
In response to chemokine stimulation, PKCalpha phosphorylates DOCK8 at its three serine sites, promoting DOCK8 separation from LRCH1 and translocation to the leading edge to guide T cell migration. Point mutations at the DOCK8 serine sites block chemokine- and PKCalpha-ind …
In response to chemokine stimulation, PKCalpha phosphorylates DOCK8 at its three serine sites, promoting DOCK8 separation from LRCH1 …
Probing the diabetes and colorectal cancer relationship using gene - environment interaction analyses.
Dimou N, Kim AE, Flanagan O, Murphy N, Diez-Obrero V, Shcherbina A, Aglago EK, Bouras E, Campbell PT, Casey G, Gallinger S, Gruber SB, Jenkins MA, Lin Y, Moreno V, Ruiz-Narvaez E, Stern MC, Tian Y, Tsilidis KK, Arndt V, Barry EL, Baurley JW, Berndt SI, Bézieau S, Bien SA, Bishop DT, Brenner H, Budiarto A, Carreras-Torres R, Cenggoro TW, Chan AT, Chang-Claude J, Chanock SJ, Chen X, Conti DV, Dampier CH, Devall M, Drew DA, Figueiredo JC, Giles GG, Gsur A, Harrison TA, Hidaka A, Hoffmeister M, Huyghe JR, Jordahl K, Kawaguchi E, Keku TO, Larsson SC, Le Marchand L, Lewinger JP, Li L, Mahesworo B, Morrison J, Newcomb PA, Newton CC, Obon-Santacana M, Ose J, Pai RK, Palmer JR, Papadimitriou N, Pardamean B, Peoples AR, Pharoah PDP, Platz EA, Potter JD, Rennert G, Scacheri PC, Schoen RE, Su YR, Tangen CM, Thibodeau SN, Thomas DC, Ulrich CM, Um CY, van Duijnhoven FJB, Visvanathan K, Vodicka P, Vodickova L, White E, Wolk A, Woods MO, Qu C, Kundaje A, Hsu L, Gauderman WJ, Gunter MJ, Peters U. Dimou N, et al. Br J Cancer. 2023 Aug;129(3):511-520. doi: 10.1038/s41416-023-02312-z. Epub 2023 Jun 26. Br J Cancer. 2023. PMID: 37365285 Free PMC article.
RESULTS: Based on the joint tests, we found that the association of diabetes with colorectal cancer risk is modified by loci on chromosomes 8q24.11 (rs3802177, SLC30A8 - OR(AA): 1.62, 95% CI: 1.34-1.96; OR(AG): 1.41, 95% CI: 1.30-1.54; OR(GG): 1.22, 95% CI: 1.13-1.31; p-value(3-d …
RESULTS: Based on the joint tests, we found that the association of diabetes with colorectal cancer risk is modified by loci on chromosomes …
Genetic association analysis of LRCH1 as an osteoarthritis susceptibility locus.
Snelling S, Sinsheimer JS, Carr A, Loughlin J. Snelling S, et al. Rheumatology (Oxford). 2007 Feb;46(2):250-2. doi: 10.1093/rheumatology/kel265. Epub 2006 Aug 5. Rheumatology (Oxford). 2007. PMID: 16891653
OBJECTIVE: A genetic association with knee osteoarthritis (OA) of a single nucleotide polymorphism (SNP) in intron 1 of the LRCH1 gene was recently reported in a UK Caucasian case-control sample and confirmed in a Newfoundland Caucasian sample. ...There was also no signifi …
OBJECTIVE: A genetic association with knee osteoarthritis (OA) of a single nucleotide polymorphism (SNP) in intron 1 of the LRCH1 gen …
Leucine rich repeats and calponin homology domain containing 1 inhibits NK-92 cell cytotoxicity through attenuating Src signaling.
Dai K, Chen Z, She S, Shi J, Zhu J, Huang Y. Dai K, et al. Immunobiology. 2020 May;225(3):151934. doi: 10.1016/j.imbio.2020.151934. Epub 2020 Mar 9. Immunobiology. 2020. PMID: 32173150
Leucine-rich repeats and calponin homology domain containing 1 (LRCH1) is a novel gene of which the function is unclear. In the present study, we investigated the role of LRCH1 in NK-92 cell cytotoxicity. LRCH1 was ablated in NK-92 cells through CRISP-Cas9-me …
Leucine-rich repeats and calponin homology domain containing 1 (LRCH1) is a novel gene of which the function is unclear. In the prese …
Association between a variation in LRCH1 and knee osteoarthritis: a genome-wide single-nucleotide polymorphism association study using DNA pooling.
Spector TD, Reneland RH, Mah S, Valdes AM, Hart DJ, Kammerer S, Langdown M, Hoyal CR, Atienza J, Doherty M, Rahman P, Nelson MR, Braun A. Spector TD, et al. Arthritis Rheum. 2006 Feb;54(2):524-32. doi: 10.1002/art.21624. Arthritis Rheum. 2006. PMID: 16447229 Free article.
CONCLUSION: A genetic variant in LRCH1 was consistently associated with knee OA in 3 samples from 2 populations. ...Additional genetic and experimental work is needed to elucidate the precise mechanism by which the LRCH1 gene influences OA risk....
CONCLUSION: A genetic variant in LRCH1 was consistently associated with knee OA in 3 samples from 2 populations. ...Additional geneti …
Inhibition of leucine-rich repeats and calponin homology domain containing 1 accelerates microglia-mediated neuroinflammation in a rat traumatic spinal cord injury model.
Chen WK, Feng LJ, Liu QD, Ke QF, Cai PY, Zhang PR, Cai LQ, Huang NL, Lin WP. Chen WK, et al. J Neuroinflammation. 2020 Jul 6;17(1):202. doi: 10.1186/s12974-020-01884-4. J Neuroinflammation. 2020. PMID: 32631435 Free PMC article.
Microglia play a pivotal role in the initiation and progression of post-SCI neuroinflammation. METHODS: To elucidate the significance of LRCH1 to microglial functions, we applied lentivirus-induced LRCH1 knockdown in primary microglia culture and tested the role of …
Microglia play a pivotal role in the initiation and progression of post-SCI neuroinflammation. METHODS: To elucidate the significance of …
Lack of association of single nucleotide polymorphism in LRCH1 with knee osteoarthritis susceptibility.
Jiang Q, Shi D, Nakajima M, Dai J, Wei J, Malizos KN, Qin J, Miyamoto Y, Kamatani N, Liu B, Tsezou A, Nakamura T, Ikegawa S. Jiang Q, et al. J Hum Genet. 2008;53(1):42. doi: 10.1007/s10038-007-0216-4. Epub 2007 Nov 30. J Hum Genet. 2008. PMID: 18049793
A genetic association of knee osteoarthritis (OA) and a C/T transition single nucleotide polymorphism (SNP) (rs912428) located in intron 1 of the LRCH1 gene has recently been reported in European Caucasians; however, the results are inconsistent. ...Meta-analysis also supp …
A genetic association of knee osteoarthritis (OA) and a C/T transition single nucleotide polymorphism (SNP) (rs912428) located in intron 1 o …
23 results