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E3 ubiquitin ligase ASB8 negatively regulates interferon via regulating TBK1/IKKi homeostasis.
Guo Y, Li R, Tan Z, Shi J, Fu Y, Song Y, Zhu M, Zhang L, Huang J. Guo Y, et al. Mol Immunol. 2020 May;121:195-203. doi: 10.1016/j.molimm.2020.03.011. Epub 2020 Apr 14. Mol Immunol. 2020. PMID: 32298923
At the same time, a new bridge molecule Leucine-rich repeat containing protein 10B(LRRC10B) upregulated after viral infection are involved in the formation and interaction with ASB8-TBK1/IKKi complex was reported. ...
At the same time, a new bridge molecule Leucine-rich repeat containing protein 10B(LRRC10B) upregulated after viral infection are inv …
Association of DNA Methylation in Blood Pressure-Related Genes With Ischemic Stroke Risk and Prognosis.
Zhang H, Mo X, Wang A, Peng H, Guo D, Zhong C, Zhu Z, Xu T, Zhang Y. Zhang H, et al. Front Cardiovasc Med. 2022 Mar 8;9:796245. doi: 10.3389/fcvm.2022.796245. eCollection 2022. Front Cardiovasc Med. 2022. PMID: 35345488 Free PMC article.
The associations between methylation levels and ischemic stroke risk and prognosis were evaluated. RESULTS: Methylation of AMH, C17orf82, HDAC9, IGFBP3, LRRC10B, PDE3A, PRDM6, SYT7 and TBX2 was significantly associated with ischemic stroke. ...
The associations between methylation levels and ischemic stroke risk and prognosis were evaluated. RESULTS: Methylation of AMH, C17orf82, HD …
CREB Promotes Beta Cell Gene Expression by Targeting Its Coactivators to Tissue-Specific Enhancers.
Van de Velde S, Wiater E, Tran M, Hwang Y, Cole PA, Montminy M. Van de Velde S, et al. Mol Cell Biol. 2019 Aug 12;39(17):e00200-19. doi: 10.1128/MCB.00200-19. Print 2019 Sep 1. Mol Cell Biol. 2019. PMID: 31182641 Free PMC article.
Neurod1 appears critical in establishing nucleosome-free regions for recruitment of CREB to beta cell-specific enhancers. Deletion of a CREB-Neurod1-bound enhancer within the Lrrc10b-Syt7 superenhancer disrupted the expression of both genes and decreased beta cell function …
Neurod1 appears critical in establishing nucleosome-free regions for recruitment of CREB to beta cell-specific enhancers. Deletion of a CREB …
Low expression lncRNA RPLP0P2 is associated with poor prognosis and decreased cell proliferation and adhesion ability in lung adenocarcinoma.
Chen J, Hu L, Chen J, Wu F, Hu D, Xu G, Zhu P, Wang Y. Chen J, et al. Oncol Rep. 2016 Sep;36(3):1665-71. doi: 10.3892/or.2016.4965. Epub 2016 Jul 22. Oncol Rep. 2016. PMID: 27460542
We overexpressed RPLP0P2 based on the human LAD cell line A549 by lentivirus-mediated technology, then oncological behavior change was observed of A549 cells and the change of mRNA level of LRRC10B and RPLP0P2 by qPCR. We found that RPLP0P2 expression was lower while LR …
We overexpressed RPLP0P2 based on the human LAD cell line A549 by lentivirus-mediated technology, then oncological behavior change was obser …