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Ribosome-associated quality-control mechanisms from bacteria to humans.
Filbeck S, Cerullo F, Pfeffer S, Joazeiro CAP. Filbeck S, et al. Mol Cell. 2022 Apr 21;82(8):1451-1466. doi: 10.1016/j.molcel.2022.03.038. Mol Cell. 2022. PMID: 35452614 Free PMC article. Review.
Central players in RQC are the human ribosome- and tRNA-binding protein, NEMF, and its orthologs, yeast Rqc2 and bacterial RqcH, which sense large ribosomal subunits obstructed with nascent chains and then promote nascent-chain proteolysis. In canonical eukaryotic RQC, NEMF stabi …
Central players in RQC are the human ribosome- and tRNA-binding protein, NEMF, and its orthologs, yeast Rqc2 and bacterial RqcH, which sense …
LTN1 promotes RLR degradation to inhibit immune response to RNA virus through the ESCRT pathway.
Qin F, Cai B, Wang P, Cao R, Zhang Y, Wen H, Zheng Y, Zhao W, Gao C, Liu B. Qin F, et al. Autophagy. 2023 Dec 7:1-16. doi: 10.1080/15548627.2023.2291939. Online ahead of print. Autophagy. 2023. PMID: 38060409
However, whether the ESCRT system participates in regulating RIGI-like receptor (RLR)-mediated antiviral responses remains unknown. In this study, we show that LTN1/listerin, a major component of RQC, can recruit E3 ubiquitin ligase TRIM27 to trigger K63-linked polyubiquit …
However, whether the ESCRT system participates in regulating RIGI-like receptor (RLR)-mediated antiviral responses remains unknown. In this …
Mechanisms and functions of ribosome-associated protein quality control.
Joazeiro CAP. Joazeiro CAP. Nat Rev Mol Cell Biol. 2019 Jun;20(6):368-383. doi: 10.1038/s41580-019-0118-2. Nat Rev Mol Cell Biol. 2019. PMID: 30940912 Free PMC article. Review.
In eukaryotes, this function is carried out by a dedicated surveillance mechanism known as ribosome-associated protein quality control (RQC). The E3 ubiquitin ligase Ltn1 (listerin in mammals) plays a key part in RQC by targeting the aberrant nascent polypeptides for prote …
In eukaryotes, this function is carried out by a dedicated surveillance mechanism known as ribosome-associated protein quality control (RQC) …
In vivo CRISPR screen identifies LTN1 as a novel tumor suppressor ubiquitinating insulin-like growth factor 2 mRNA-binding protein 1 in hepatocellular carcinoma.
Peng R, Cao J, Zhang C, Zhou J, Su BB, Tu DY, Jiang GQ, Jin SJ, Xu YP, Bai DS. Peng R, et al. Hepatol Commun. 2023 Sep 15;7(10):e0256. doi: 10.1097/HC9.0000000000000256. eCollection 2023 Oct 1. Hepatol Commun. 2023. PMID: 37708447 Free PMC article.
Compared to matched normal tissues, the expression of LTN1 was decreased in human HCC tissues (ANT) (157/209). Clinically, patients with HCC who expressed low levels of LTN1 had a poor prognosis. Forced expression of LTN1 decreased cell growth in vitro and in …
Compared to matched normal tissues, the expression of LTN1 was decreased in human HCC tissues (ANT) (157/209). Clinically, patients w …
Argonaute-dependent ribosome-associated protein quality control.
Gao Y, Zhu Y, Sun Q, Chen D. Gao Y, et al. Trends Cell Biol. 2023 Mar;33(3):260-272. doi: 10.1016/j.tcb.2022.07.007. Epub 2022 Aug 16. Trends Cell Biol. 2023. PMID: 35981909 Free article. Review.
Ribosome-associated protein quality control (RQC) is a protein surveillance mechanism that eliminates defective nascent polypeptides. The E3 ubiquitin ligase, Ltn1, is a key regulator of RQC that targets substrates for ubiquitination. Argonaute proteins (AGOs) are central …
Ribosome-associated protein quality control (RQC) is a protein surveillance mechanism that eliminates defective nascent polypeptides. The E3 …
Rkr1/Ltn1 Ubiquitin Ligase-mediated Degradation of Translationally Stalled Endoplasmic Reticulum Proteins.
Crowder JJ, Geigges M, Gibson RT, Fults ES, Buchanan BW, Sachs N, Schink A, Kreft SG, Rubenstein EM. Crowder JJ, et al. J Biol Chem. 2015 Jul 24;290(30):18454-66. doi: 10.1074/jbc.M115.663559. Epub 2015 Jun 8. J Biol Chem. 2015. PMID: 26055716 Free PMC article.
If a stop codon is not encountered, translation continues into the poly(A) tail, resulting in C-terminal appendage of a polylysine tract and a terminally stalled ribosome. In Saccharomyces cerevisiae, the ubiquitin ligase Rkr1/Ltn1 has been implicated in the proteasomal de …
If a stop codon is not encountered, translation continues into the poly(A) tail, resulting in C-terminal appendage of a polylysine tract and …
Structure and function of the yeast listerin (Ltn1) conserved N-terminal domain in binding to stalled 60S ribosomal subunits.
Doamekpor SK, Lee JW, Hepowit NL, Wu C, Charenton C, Leonard M, Bengtson MH, Rajashankar KR, Sachs MS, Lima CD, Joazeiro CA. Doamekpor SK, et al. Proc Natl Acad Sci U S A. 2016 Jul 19;113(29):E4151-60. doi: 10.1073/pnas.1605951113. Epub 2016 Jul 6. Proc Natl Acad Sci U S A. 2016. PMID: 27385828 Free PMC article.
The Ltn1 E3 ligase (listerin in mammals) has emerged as a paradigm for understanding ribosome-associated ubiquitylation. Ltn1 binds to 60S ribosomal subunits to ubiquitylate nascent polypeptides that become stalled during synthesis; among Ltn1's substrates ar …
The Ltn1 E3 ligase (listerin in mammals) has emerged as a paradigm for understanding ribosome-associated ubiquitylation. Ltn1 …
Rqc1 and Ltn1 Prevent C-terminal Alanine-Threonine Tail (CAT-tail)-induced Protein Aggregation by Efficient Recruitment of Cdc48 on Stalled 60S Subunits.
Defenouillère Q, Zhang E, Namane A, Mouaikel J, Jacquier A, Fromont-Racine M. Defenouillère Q, et al. J Biol Chem. 2016 Jun 3;291(23):12245-53. doi: 10.1074/jbc.M116.722264. Epub 2016 Apr 18. J Biol Chem. 2016. PMID: 27129255 Free PMC article.
Stalled ribosomes are dissociated, aberrant mRNAs are degraded by the cytoplasmic exosome, and the nascent peptides remaining in stalled 60S exit tunnels are detected by the ribosome-bound quality control complex (RQC) composed of Ltn1, Rqc1, Rqc2, and Cdc48. Whereas Lt …
Stalled ribosomes are dissociated, aberrant mRNAs are degraded by the cytoplasmic exosome, and the nascent peptides remaining in stalled 60S …
Ubiquitylation by the Ltn1 E3 ligase protects 60S ribosomes from starvation-induced selective autophagy.
Ossareh-Nazari B, Niño CA, Bengtson MH, Lee JW, Joazeiro CA, Dargemont C. Ossareh-Nazari B, et al. J Cell Biol. 2014 Mar 17;204(6):909-17. doi: 10.1083/jcb.201308139. Epub 2014 Mar 10. J Cell Biol. 2014. PMID: 24616224 Free PMC article.
Consistently, the expression of Ltn1-but not Ubp3-rapidly decreased after starvation, presumably to allow ribophagy to proceed. Thus, Ltn1 and Ubp3-Bre5 likely contribute to adapt ribophagy activity to both nutrient supply and protein translation....
Consistently, the expression of Ltn1-but not Ubp3-rapidly decreased after starvation, presumably to allow ribophagy to proceed. Thus, …
Cooperativity between the Ribosome-Associated Chaperone Ssb/RAC and the Ubiquitin Ligase Ltn1 in Ubiquitination of Nascent Polypeptides.
Ghosh A, Shcherbik N. Ghosh A, et al. Int J Mol Sci. 2020 Sep 17;21(18):6815. doi: 10.3390/ijms21186815. Int J Mol Sci. 2020. PMID: 32957466 Free PMC article.
Here, we provide evidence that Ssb/RAC and the ubiquitin ligase Ltn1, the major component of RQC, display genetic and functional cooperativity. Overexpression of Ltn1 rescues growth suppression of the yeast strain-bearing deletions of SSB genes during proteotoxic st …
Here, we provide evidence that Ssb/RAC and the ubiquitin ligase Ltn1, the major component of RQC, display genetic and functional coop …
92 results