Lu J - Search Results

1

Reducing target binding affinity improves the therapeutic index of anti-MET antibody-drug conjugate in tumor bearing animals.

Datta-Mannan A, Choi H, Jin Z, Liu L, Lu J, Stokell DJ, Murphy AT, Dunn KW, Martinez MM, Feng Y. Datta-Mannan A, et al. Among authors: lu j. PLoS One. 2024 Apr 17;19(4):e0293703. doi: 10.1371/journal.pone.0293703. eCollection 2024. PLoS One. 2024. PMID: 38630694 Free PMC article.

2

Influence of improved FcRn binding on the subcutaneous bioavailability of monoclonal antibodies in cynomolgus monkeys.

Datta-Mannan A, Witcher DR, Lu J, Wroblewski VJ. Datta-Mannan A, et al. Among authors: lu j. MAbs. 2012 Mar-Apr;4(2):267-73. doi: 10.4161/mabs.4.2.19364. Epub 2012 Mar 1. MAbs. 2012. PMID: 22377715 Free PMC article.

3

The interplay of non-specific binding, target-mediated clearance and FcRn interactions on the pharmacokinetics of humanized antibodies.

Datta-Mannan A, Lu J, Witcher DR, Leung D, Tang Y, Wroblewski VJ. Datta-Mannan A, et al. Among authors: lu j. MAbs. 2015;7(6):1084-93. doi: 10.1080/19420862.2015.1075109. Epub 2015 Sep 4. MAbs. 2015. PMID: 26337808 Free PMC article.

4

Balancing charge in the complementarity-determining regions of humanized mAbs without affecting pI reduces non-specific binding and improves the pharmacokinetics.

Datta-Mannan A, Thangaraju A, Leung D, Tang Y, Witcher DR, Lu J, Wroblewski VJ. Datta-Mannan A, et al. Among authors: lu j. MAbs. 2015;7(3):483-93. doi: 10.1080/19420862.2015.1016696. MAbs. 2015. PMID: 25695748 Free PMC article.

5

FcRn affinity-pharmacokinetic relationship of five human IgG4 antibodies engineered for improved in vitro FcRn binding properties in cynomolgus monkeys.

Datta-Mannan A, Chow CK, Dickinson C, Driver D, Lu J, Witcher DR, Wroblewski VJ. Datta-Mannan A, et al. Among authors: lu j. Drug Metab Dispos. 2012 Aug;40(8):1545-55. doi: 10.1124/dmd.112.045864. Epub 2012 May 14. Drug Metab Dispos. 2012. PMID: 22584253

6

LY2875358, a neutralizing and internalizing anti-MET bivalent antibody, inhibits HGF-dependent and HGF-independent MET activation and tumor growth.

Liu L, Zeng W, Wortinger MA, Yan SB, Cornwell P, Peek VL, Stephens JR, Tetreault JW, Xia J, Manro JR, Credille KM, Ballard DW, Brown-Augsburger P, Wacheck V, Chow CK, Huang L, Wang Y, Denning I, Davies J, Tang Y, Vaillancourt P, Lu J. Liu L, et al. Among authors: lu j. Clin Cancer Res. 2014 Dec 1;20(23):6059-70. doi: 10.1158/1078-0432.CCR-14-0543. Epub 2014 Sep 17. Clin Cancer Res. 2014. PMID: 25231402

7

Influence of physiochemical properties on the subcutaneous absorption and bioavailability of monoclonal antibodies.

Datta-Mannan A, Estwick S, Zhou C, Choi H, Douglass NE, Witcher DR, Lu J, Beidler C, Millican R. Datta-Mannan A, et al. Among authors: lu j. MAbs. 2020 Jan 1;12(1):1770028. doi: 10.1080/19420862.2020.1770028. MAbs. 2020. PMID: 32486889 Free PMC article.

8

Reconstruction of 3D structures of MET antibodies from electron microscopy 2D class averages.

Chen Q, Vieth M, Timm DE, Humblet C, Schneidman-Duhovny D, Chemmama IE, Sali A, Zeng W, Lu J, Liu L. Chen Q, et al. Among authors: lu j. PLoS One. 2017 Apr 13;12(4):e0175758. doi: 10.1371/journal.pone.0175758. eCollection 2017. PLoS One. 2017. PMID: 28406969 Free PMC article.

9

Generation and characterization of ixekizumab, a humanized monoclonal antibody that neutralizes interleukin-17A.

Liu L, Lu J, Allan BW, Tang Y, Tetreault J, Chow CK, Barmettler B, Nelson J, Bina H, Huang L, Wroblewski VJ, Kikly K. Liu L, et al. Among authors: lu j. J Inflamm Res. 2016 Apr 19;9:39-50. doi: 10.2147/JIR.S100940. eCollection 2016. J Inflamm Res. 2016. PMID: 27143947 Free PMC article.

10

Immunohistochemical application of a highly sensitive and specific murine monoclonal antibody recognising the extracellular domain of the human hepatocyte growth factor receptor (MET).

Gruver AM, Liu L, Vaillancourt P, Yan SC, Cook JD, Roseberry Baker JA, Felke EM, Lacy ME, Marchal CC, Szpurka H, Holzer TR, Rhoads EK, Zeng W, Wortinger MA, Lu J, Chow CK, Denning IJ, Beuerlein G, Davies J, Hanson JC, Credille KM, Wijayawardana SR, Schade AE. Gruver AM, et al. Among authors: lu j. Histopathology. 2014 Dec;65(6):879-96. doi: 10.1111/his.12510. Epub 2014 Oct 6. Histopathology. 2014. PMID: 25039923 Free article.

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