Lubben TH - Search Results

1

Selective protein tyrosine phosphatase 1B inhibitors: targeting the second phosphotyrosine binding site with non-carboxylic acid-containing ligands.

Liu G, Xin Z, Liang H, Abad-Zapatero C, Hajduk PJ, Janowick DA, Szczepankiewicz BG, Pei Z, Hutchins CW, Ballaron SJ, Stashko MA, Lubben TH, Berg CE, Rondinone CM, Trevillyan JM, Jirousek MR. Liu G, et al. Among authors: lubben th. J Med Chem. 2003 Jul 31;46(16):3437-40. doi: 10.1021/jm034088d. J Med Chem. 2003. PMID: 12877578

2

In vitro enzymatic assays of protein tyrosine phosphatase 1B.

Lubben T, Clampit J, Stashko M, Trevillyan J, Jirousek MR. Lubben T, et al. Curr Protoc Pharmacol. 2001 Aug;Chapter 3:Unit3.8. doi: 10.1002/0471141755.ph0308s13. Curr Protoc Pharmacol. 2001. PMID: 21959757

3

Discovery and structure-activity relationship of oxalylarylaminobenzoic acids as inhibitors of protein tyrosine phosphatase 1B.

Liu G, Szczepankiewicz BG, Pei Z, Janowick DA, Xin Z, Hajduk PJ, Abad-Zapatero C, Liang H, Hutchins CW, Fesik SW, Ballaron SJ, Stashko MA, Lubben T, Mika AK, Zinker BA, Trevillyan JM, Jirousek MR. Liu G, et al. J Med Chem. 2003 May 22;46(11):2093-103. doi: 10.1021/jm0205696. J Med Chem. 2003. PMID: 12747781

4

Potent, selective inhibitors of protein tyrosine phosphatase 1B.

Xin Z, Oost TK, Abad-Zapatero C, Hajduk PJ, Pei Z, Szczepankiewicz BG, Hutchins CW, Ballaron SJ, Stashko MA, Lubben T, Trevillyan JM, Jirousek MR, Liu G. Xin Z, et al. Bioorg Med Chem Lett. 2003 Jun 2;13(11):1887-90. doi: 10.1016/s0960-894x(03)00302-0. Bioorg Med Chem Lett. 2003. PMID: 12749891

5

Discovery and SAR of novel, potent and selective protein tyrosine phosphatase 1B inhibitors.

Pei Z, Li X, Liu G, Abad-Zapatero C, Lubben T, Zhang T, Ballaron SJ, Hutchins CW, Trevillyan JM, Jirousek MR. Pei Z, et al. Bioorg Med Chem Lett. 2003 Oct 6;13(19):3129-32. doi: 10.1016/s0960-894x(03)00725-x. Bioorg Med Chem Lett. 2003. PMID: 12951078

6

Discovery of a potent, selective protein tyrosine phosphatase 1B inhibitor using a linked-fragment strategy.

Szczepankiewicz BG, Liu G, Hajduk PJ, Abad-Zapatero C, Pei Z, Xin Z, Lubben TH, Trevillyan JM, Stashko MA, Ballaron SJ, Liang H, Huang F, Hutchins CW, Fesik SW, Jirousek MR. Szczepankiewicz BG, et al. Among authors: lubben th. J Am Chem Soc. 2003 Apr 9;125(14):4087-96. doi: 10.1021/ja0296733. J Am Chem Soc. 2003. PMID: 12670229

7

Fragment screening and assembly: a highly efficient approach to a selective and cell active protein tyrosine phosphatase 1B inhibitor.

Liu G, Xin Z, Pei Z, Hajduk PJ, Abad-Zapatero C, Hutchins CW, Zhao H, Lubben TH, Ballaron SJ, Haasch DL, Kaszubska W, Rondinone CM, Trevillyan JM, Jirousek MR. Liu G, et al. Among authors: lubben th. J Med Chem. 2003 Sep 25;46(20):4232-5. doi: 10.1021/jm034122o. J Med Chem. 2003. PMID: 13678400

8

Identification of a monoacid-based, cell permeable, selective inhibitor of protein tyrosine phosphatase 1B.

Xin Z, Liu G, Abad-Zapatero C, Pei Z, Szczepankiewicz BG, Li X, Zhang T, Hutchins CW, Hajduk PJ, Ballaron SJ, Stashko MA, Lubben TH, Trevillyan JM, Jirousek MR. Xin Z, et al. Among authors: lubben th. Bioorg Med Chem Lett. 2003 Nov 17;13(22):3947-50. doi: 10.1016/j.bmcl.2003.08.064. Bioorg Med Chem Lett. 2003. PMID: 14592481

9

Isoxazole carboxylic acids as protein tyrosine phosphatase 1B (PTP1B) inhibitors.

Zhao H, Liu G, Xin Z, Serby MD, Pei Z, Szczepankiewicz BG, Hajduk PJ, Abad-Zapatero C, Hutchins CW, Lubben TH, Ballaron SJ, Haasch DL, Kaszubska W, Rondinone CM, Trevillyan JM, Jirousek MR. Zhao H, et al. Among authors: lubben th. Bioorg Med Chem Lett. 2004 Nov 15;14(22):5543-6. doi: 10.1016/j.bmcl.2004.08.063. Bioorg Med Chem Lett. 2004. PMID: 15482920

10

Inhibition of protein tyrosine phosphatase 1B as a potential treatment of diabetes and obesity.

Pei Z, Liu G, Lubben TH, Szczepankiewicz BG. Pei Z, et al. Among authors: lubben th. Curr Pharm Des. 2004;10(28):3481-504. doi: 10.2174/1381612043382954. Curr Pharm Des. 2004. PMID: 15579047 Review.

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