Luk LY - Search Results

1

Effect of dimerization on dihydrofolate reductase catalysis.

Guo J, Loveridge EJ, Luk LY, Allemann RK. Guo J, et al. Among authors: luk ly. Biochemistry. 2013 Jun 4;52(22):3881-7. doi: 10.1021/bi4005073. Epub 2013 May 22. Biochemistry. 2013. PMID: 23672258

2

Unraveling the role of protein dynamics in dihydrofolate reductase catalysis.

Luk LY, Javier Ruiz-Pernía J, Dawson WM, Roca M, Loveridge EJ, Glowacki DR, Harvey JN, Mulholland AJ, Tuñón I, Moliner V, Allemann RK. Luk LY, et al. Proc Natl Acad Sci U S A. 2013 Oct 8;110(41):16344-9. doi: 10.1073/pnas.1312437110. Epub 2013 Sep 24. Proc Natl Acad Sci U S A. 2013. PMID: 24065822 Free PMC article.

3

Increased dynamic effects in a catalytically compromised variant of Escherichia coli dihydrofolate reductase.

Ruiz-Pernia JJ, Luk LY, García-Meseguer R, Martí S, Loveridge EJ, Tuñón I, Moliner V, Allemann RK. Ruiz-Pernia JJ, et al. Among authors: luk ly. J Am Chem Soc. 2013 Dec 11;135(49):18689-96. doi: 10.1021/ja410519h. Epub 2013 Nov 26. J Am Chem Soc. 2013. PMID: 24252106 Free PMC article.

4

Thermal adaptation of dihydrofolate reductase from the moderate thermophile Geobacillus stearothermophilus.

Guo J, Luk LY, Loveridge EJ, Allemann RK. Guo J, et al. Among authors: luk ly. Biochemistry. 2014 May 6;53(17):2855-63. doi: 10.1021/bi500238q. Epub 2014 Apr 22. Biochemistry. 2014. PMID: 24730604 Free PMC article.

5

Different dynamical effects in mesophilic and hyperthermophilic dihydrofolate reductases.

Luk LY, Loveridge EJ, Allemann RK. Luk LY, et al. J Am Chem Soc. 2014 May 14;136(19):6862-5. doi: 10.1021/ja502673h. Epub 2014 May 5. J Am Chem Soc. 2014. PMID: 24779446 Free PMC article.

6

Role of the occluded conformation in bacterial dihydrofolate reductases.

Behiry EM, Luk LY, Matthews SM, Loveridge EJ, Allemann RK. Behiry EM, et al. Among authors: luk ly. Biochemistry. 2014 Jul 29;53(29):4761-8. doi: 10.1021/bi500507v. Epub 2014 Jul 18. Biochemistry. 2014. PMID: 25014833 Free article.

7

Protein isotope effects in dihydrofolate reductase from Geobacillus stearothermophilus show entropic-enthalpic compensatory effects on the rate constant.

Luk LY, Ruiz-Pernía JJ, Dawson WM, Loveridge EJ, Tuñón I, Moliner V, Allemann RK. Luk LY, et al. J Am Chem Soc. 2014 Dec 10;136(49):17317-23. doi: 10.1021/ja5102536. Epub 2014 Nov 26. J Am Chem Soc. 2014. PMID: 25396728

8

Protein motions and dynamic effects in enzyme catalysis.

Luk LY, Loveridge EJ, Allemann RK. Luk LY, et al. Phys Chem Chem Phys. 2015 Dec 14;17(46):30817-27. doi: 10.1039/c5cp00794a. Phys Chem Chem Phys. 2015. PMID: 25854702

9

Chemical Ligation and Isotope Labeling to Locate Dynamic Effects during Catalysis by Dihydrofolate Reductase.

Luk LY, Ruiz-Pernía JJ, Adesina AS, Loveridge EJ, Tuñón I, Moliner V, Allemann RK. Luk LY, et al. Angew Chem Int Ed Engl. 2015 Jul 27;54(31):9016-20. doi: 10.1002/anie.201503968. Epub 2015 Jun 16. Angew Chem Int Ed Engl. 2015. PMID: 26079622 Free PMC article.

10

Reduction of Folate by Dihydrofolate Reductase from Thermotoga maritima.

Loveridge EJ, Hroch L, Hughes RL, Williams T, Davies RL, Angelastro A, Luk LY, Maglia G, Allemann RK. Loveridge EJ, et al. Among authors: luk ly. Biochemistry. 2017 Apr 4;56(13):1879-1886. doi: 10.1021/acs.biochem.6b01268. Epub 2017 Mar 24. Biochemistry. 2017. PMID: 28319664 Free article.

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