Luttrell LM - Search Results

1

'Biasing' the parathyroid hormone receptor: a novel anabolic approach to increasing bone mass?

Gesty-Palmer D, Luttrell LM. Gesty-Palmer D, et al. Among authors: luttrell lm. Br J Pharmacol. 2011 Sep;164(1):59-67. doi: 10.1111/j.1476-5381.2011.01450.x. Br J Pharmacol. 2011. PMID: 21506957 Free PMC article. Review.

2

Distinct beta-arrestin- and G protein-dependent pathways for parathyroid hormone receptor-stimulated ERK1/2 activation.

Gesty-Palmer D, Chen M, Reiter E, Ahn S, Nelson CD, Wang S, Eckhardt AE, Cowan CL, Spurney RF, Luttrell LM, Lefkowitz RJ. Gesty-Palmer D, et al. Among authors: luttrell lm. J Biol Chem. 2006 Apr 21;281(16):10856-64. doi: 10.1074/jbc.M513380200. Epub 2006 Feb 21. J Biol Chem. 2006. PMID: 16492667 Free article.

3

A beta-arrestin-biased agonist of the parathyroid hormone receptor (PTH1R) promotes bone formation independent of G protein activation.

Gesty-Palmer D, Flannery P, Yuan L, Corsino L, Spurney R, Lefkowitz RJ, Luttrell LM. Gesty-Palmer D, et al. Among authors: luttrell lm. Sci Transl Med. 2009 Oct 7;1(1):1ra1. doi: 10.1126/scitranslmed.3000071. Sci Transl Med. 2009. PMID: 20368153 Free PMC article.

4

Refining efficacy: exploiting functional selectivity for drug discovery.

Gesty-Palmer D, Luttrell LM. Gesty-Palmer D, et al. Among authors: luttrell lm. Adv Pharmacol. 2011;62:79-107. doi: 10.1016/B978-0-12-385952-5.00009-9. Adv Pharmacol. 2011. PMID: 21907907 Review.

5

β-arrestin-selective G protein-coupled receptor agonists engender unique biological efficacy in vivo.

Gesty-Palmer D, Yuan L, Martin B, Wood WH 3rd, Lee MH, Janech MG, Tsoi LC, Zheng WJ, Luttrell LM, Maudsley S. Gesty-Palmer D, et al. Among authors: luttrell lm. Mol Endocrinol. 2013 Feb;27(2):296-314. doi: 10.1210/me.2012-1091. Epub 2013 Jan 11. Mol Endocrinol. 2013. PMID: 23315939 Free PMC article.

6

Delineation of a conserved arrestin-biased signaling repertoire in vivo.

Maudsley S, Martin B, Gesty-Palmer D, Cheung H, Johnson C, Patel S, Becker KG, Wood WH 3rd, Zhang Y, Lehrmann E, Luttrell LM. Maudsley S, et al. Among authors: luttrell lm. Mol Pharmacol. 2015 Apr;87(4):706-17. doi: 10.1124/mol.114.095224. Epub 2015 Jan 30. Mol Pharmacol. 2015. PMID: 25637603 Free PMC article.

7

Translating in vitro ligand bias into in vivo efficacy.

Luttrell LM, Maudsley S, Gesty-Palmer D. Luttrell LM, et al. Cell Signal. 2018 Jan;41:46-55. doi: 10.1016/j.cellsig.2017.05.002. Epub 2017 May 7. Cell Signal. 2018. PMID: 28495495 Free PMC article. Review.

8

The stability of the G protein-coupled receptor-beta-arrestin interaction determines the mechanism and functional consequence of ERK activation.

Tohgo A, Choy EW, Gesty-Palmer D, Pierce KL, Laporte S, Oakley RH, Caron MG, Lefkowitz RJ, Luttrell LM. Tohgo A, et al. Among authors: luttrell lm. J Biol Chem. 2003 Feb 21;278(8):6258-67. doi: 10.1074/jbc.M212231200. Epub 2002 Dec 6. J Biol Chem. 2003. PMID: 12473660 Free article.

9

beta-Arrestin 2 expression determines the transcriptional response to lysophosphatidic acid stimulation in murine embryo fibroblasts.

Gesty-Palmer D, El Shewy H, Kohout TA, Luttrell LM. Gesty-Palmer D, et al. Among authors: luttrell lm. J Biol Chem. 2005 Sep 16;280(37):32157-67. doi: 10.1074/jbc.M507460200. Epub 2005 Jul 15. J Biol Chem. 2005. PMID: 16027114 Free article.

10

Heptahelical terpsichory. Who calls the tune?

Gesty-Palmer D, Luttrell LM. Gesty-Palmer D, et al. Among authors: luttrell lm. J Recept Signal Transduct Res. 2008;28(1-2):39-58. doi: 10.1080/10799890801941921. J Recept Signal Transduct Res. 2008. PMID: 18437629 Review.

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