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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1952 1
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1982 6
1984 3
1985 4
1986 4
1987 7
1988 5
1989 5
1990 5
1991 23
1992 37
1993 31
1994 61
1995 85
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1997 85
1998 84
1999 92
2000 90
2001 130
2002 117
2003 111
2004 106
2005 104
2006 112
2007 124
2008 130
2009 146
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2015 186
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2020 182
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2023 148
2024 59

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3,668 results

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Page 1
The Src-family Kinase Lyn in Immunoreceptor Signaling.
Brian BF 4th, Freedman TS. Brian BF 4th, et al. Endocrinology. 2021 Oct 1;162(10):bqab152. doi: 10.1210/endocr/bqab152. Endocrinology. 2021. PMID: 34320188 Free PMC article. Review.
Defects in Lyn signaling are implicated in autoimmune disease, but mechanisms by which Lyn, expressed along with a battery of other Src-family kinases, may uniquely direct both positive and negative signaling remain incompletely defined. ...These principles may also …
Defects in Lyn signaling are implicated in autoimmune disease, but mechanisms by which Lyn, expressed along with a battery of …
Lyn attenuates sepsis-associated acute kidney injury by inhibition of phospho-STAT3 and apoptosis.
Li N, Lin G, Zhang H, Sun J, Gui M, Liu Y, Li W, Zhan Z, Li Y, Pan S, Liu J, Tang J. Li N, et al. Biochem Pharmacol. 2023 May;211:115523. doi: 10.1016/j.bcp.2023.115523. Epub 2023 Mar 30. Biochem Pharmacol. 2023. PMID: 37003346 Free article.
Previous studies demonstrated that Lyn gene deletion obviously aggravates LPS-induced lung inflammation, but the role and possible mechanism of Lyn in SA-AKI have not been reported yet. ...Hence, Lyn kinase may be a promising therapeutic target for SA-AKI....
Previous studies demonstrated that Lyn gene deletion obviously aggravates LPS-induced lung inflammation, but the role and possible me …
Lyn, Lupus, and (B) Lymphocytes, a Lesson on the Critical Balance of Kinase Signaling in Immunity.
Brodie EJ, Infantino S, Low MSY, Tarlinton DM. Brodie EJ, et al. Front Immunol. 2018 Mar 1;9:401. doi: 10.3389/fimmu.2018.00401. eCollection 2018. Front Immunol. 2018. PMID: 29545808 Free PMC article. Review.
Its role in initiating negative signaling cascades is especially critical as exemplified by Lyn(-/-) mice developing an SLE-like disease with plasma cell hyperplasia, underscoring the importance of tightly regulating signaling within B cells. This review highlights recent …
Its role in initiating negative signaling cascades is especially critical as exemplified by Lyn(-/-) mice developing an SLE-like dise …
The role of the tyrosine kinase Lyn in allergy and cancer.
Sun Y, Yang Y, Zhao Y, Li X, Zhang Y, Liu Z. Sun Y, et al. Mol Immunol. 2021 Mar;131:121-126. doi: 10.1016/j.molimm.2020.12.028. Epub 2021 Jan 6. Mol Immunol. 2021. PMID: 33419562 Review.
This signaling molecule is vital in the IgE/FcepsilonRI signaling pathway that regulates allergy. The Lyn-FcepsilonRIbeta interaction is essential for mast cell activation. The signaling pathway of Lyn has become the focus of immune, inflammatory, tumor, and allergy …
This signaling molecule is vital in the IgE/FcepsilonRI signaling pathway that regulates allergy. The Lyn-FcepsilonRIbeta interaction …
Lyn, a src-like tyrosine kinase.
Hibbs ML, Dunn AR. Hibbs ML, et al. Int J Biochem Cell Biol. 1997 Mar;29(3):397-400. doi: 10.1016/s1357-2725(96)00104-5. Int J Biochem Cell Biol. 1997. PMID: 9202419 Review.
Lyn is a member of the src family of non-receptor protein tyrosine kinases that is predominantly expressed in haematopoietic tissues. ...Lyn deficient mice also have impaired signalling involving Fc epsilon RI in mast cells, resulting in defective allergic responses …
Lyn is a member of the src family of non-receptor protein tyrosine kinases that is predominantly expressed in haematopoietic tissues. …
Lyn tyrosine kinase: accentuating the positive and the negative.
Xu Y, Harder KW, Huntington ND, Hibbs ML, Tarlinton DM. Xu Y, et al. Immunity. 2005 Jan;22(1):9-18. doi: 10.1016/j.immuni.2004.12.004. Immunity. 2005. PMID: 15664155 Free article. Review.
Somewhat paradoxically, it is also a key mediator in several pathways of B cell activation, such as CD19 and CD180. Whether Lyn functions to promote or inhibit immune cell activation depends on the stimulus and the developmental state, meaning that the consequences of L …
Somewhat paradoxically, it is also a key mediator in several pathways of B cell activation, such as CD19 and CD180. Whether Lyn funct …
Lyn-mediated glycolysis enhancement of microglia contributes to neuropathic pain through facilitating IRF5 nuclear translocation in spinal dorsal horn.
Kong E, Li Y, Ma P, Zhang Y, Ding R, Hua T, Yang M, Yuan H. Kong E, et al. J Cell Mol Med. 2023 Jun;27(12):1664-1681. doi: 10.1111/jcmm.17759. Epub 2023 May 2. J Cell Mol Med. 2023. PMID: 37132040 Free PMC article.
Glycometabolism shift to glycolysis can promote the pro-inflammatory phenotype transition of microglia. The omics data analysis suggest a critical role for Lyn dysregulation in neuropathic pain. The present study aimed at exploring the mechanism of Lyn-mediated glyc …
Glycometabolism shift to glycolysis can promote the pro-inflammatory phenotype transition of microglia. The omics data analysis suggest a cr …
Lyn kinase regulates egress of flaviviruses in autophagosome-derived organelles.
Li MY, Naik TS, Siu LYL, Acuto O, Spooner E, Wang P, Yang X, Lin Y, Bruzzone R, Ashour J, Evans MJ, Sanyal S. Li MY, et al. Nat Commun. 2020 Oct 15;11(1):5189. doi: 10.1038/s41467-020-19028-w. Nat Commun. 2020. PMID: 33060596 Free PMC article.
Here we investigate how flaviviruses exploit Src family kinases (SFKs) for exit from infected cells. We identify Lyn as a critical component for secretion of Dengue and Zika infectious particles and their corresponding virus like particles (VLPs). Pharmacological inhibitio …
Here we investigate how flaviviruses exploit Src family kinases (SFKs) for exit from infected cells. We identify Lyn as a critical co …
Lyn Phosphorylates and Controls ROR1 Surface Dynamics During Chemotaxis of CLL Cells.
Dave Z, Vondálová Blanářová O, Čada Š, Janovská P, Zezula N, Běhal M, Hanáková K, Ganji SR, Krejci P, Gömöryová K, Peschelová H, Šmída M, Zdráhal Z, Pavlová Š, Kotašková J, Pospíšilová Š, Bryja V. Dave Z, et al. Front Cell Dev Biol. 2022 Feb 28;10:838871. doi: 10.3389/fcell.2022.838871. eCollection 2022. Front Cell Dev Biol. 2022. PMID: 35295854 Free PMC article.
We confirm the functional interaction between Lyn and ROR1 and demonstrate that Lyn kinase efficiently phosphorylates ROR1 in its kinase domain and aids the recruitment of the E3 ligase c-CBL. We show that ROR1 surface dynamics in migrating primary CLL cells as well …
We confirm the functional interaction between Lyn and ROR1 and demonstrate that Lyn kinase efficiently phosphorylates ROR1 in …
The Alternate Pathway for BCR Signaling Induced by IL-4 Requires Lyn Tyrosine Kinase.
Khan N, Rothstein TL. Khan N, et al. J Mol Biol. 2021 Jan 8;433(1):166667. doi: 10.1016/j.jmb.2020.10.002. Epub 2020 Oct 13. J Mol Biol. 2021. PMID: 33058880 Review.
Thus, Lyn operates at a branch point that determines the nature of the B cell response to BCR activation. The mechanism underlying the absolute dependence of alternate pathway signaling on Lyn is unknown. Here, our current understanding of receptor crosstalk between …
Thus, Lyn operates at a branch point that determines the nature of the B cell response to BCR activation. The mechanism underlying th …
3,668 results