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Discovery of imidazo[1,2-b]thiazole derivatives as novel SIRT1 activators.
J Med Chem. 2009 Mar 12;52(5):1275-83. doi: 10.1021/jm8012954.
J Med Chem. 2009.
PMID: 19199480
Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes.
Milne JC, Lambert PD, Schenk S, Carney DP, Smith JJ, Gagne DJ, Jin L, Boss O, Perni RB, Vu CB, Bemis JE, Xie R, Disch JS, Ng PY, Nunes JJ, Lynch AV, Yang H, Galonek H, Israelian K, Choy W, Iffland A, Lavu S, Medvedik O, Sinclair DA, Olefsky JM, Jirousek MR, Elliott PJ, Westphal CH.
Milne JC, et al. Among authors: lynch av.
Nature. 2007 Nov 29;450(7170):712-6. doi: 10.1038/nature06261.
Nature. 2007.
PMID: 18046409
Free PMC article.
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Small molecule activators of SIRT1 replicate signaling pathways triggered by calorie restriction in vivo.
Smith JJ, Kenney RD, Gagne DJ, Frushour BP, Ladd W, Galonek HL, Israelian K, Song J, Razvadauskaite G, Lynch AV, Carney DP, Johnson RJ, Lavu S, Iffland A, Elliott PJ, Lambert PD, Elliston KO, Jirousek MR, Milne JC, Boss O.
Smith JJ, et al. Among authors: lynch av.
BMC Syst Biol. 2009 Mar 10;3:31. doi: 10.1186/1752-0509-3-31.
BMC Syst Biol. 2009.
PMID: 19284563
Free PMC article.
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Discovery of oxazolo[4,5-b]pyridines and related heterocyclic analogs as novel SIRT1 activators.
Bemis JE, Vu CB, Xie R, Nunes JJ, Ng PY, Disch JS, Milne JC, Carney DP, Lynch AV, Jin L, Smith JJ, Lavu S, Iffland A, Jirousek MR, Perni RB.
Bemis JE, et al. Among authors: lynch av.
Bioorg Med Chem Lett. 2009 Apr 15;19(8):2350-3. doi: 10.1016/j.bmcl.2008.11.106. Epub 2008 Dec 6.
Bioorg Med Chem Lett. 2009.
PMID: 19303289
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Safety and efficacy of intracoronary sodium nitroprusside for the assessment of coronary fractional flow reserve.
Pedroni P, Sarmiento RA, Solernó R, Hauqui A, Oscos M, Alvarez F, Lynch AV, Giachello F, Scaglia J, Grinfeld D.
Pedroni P, et al. Among authors: lynch av.
Indian Heart J. 2018 Dec;70 Suppl 3(Suppl 3):S245-S249. doi: 10.1016/j.ihj.2017.12.008. Epub 2018 Jan 5.
Indian Heart J. 2018.
PMID: 30595267
Free PMC article.
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