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Combination of snap freezing, differential pH two-dimensional reverse-phase high-performance liquid chromatography, and iTRAQ technology for the peptidomic analysis of the effect of prolyl oligopeptidase inhibition in the rat brain.
Tenorio-Laranga J, Valero ML, Männistö PT, Sánchez del Pino M, García-Horsman JA. Tenorio-Laranga J, et al. Among authors: mannisto pt. Anal Biochem. 2009 Oct 1;393(1):80-7. doi: 10.1016/j.ab.2009.06.019. Epub 2009 Jun 17. Anal Biochem. 2009. PMID: 19539595
Issues about the physiological functions of prolyl oligopeptidase based on its discordant spatial association with substrates and inconsistencies among mRNA, protein levels, and enzymatic activity.
Myöhänen TT, García-Horsman JA, Tenorio-Laranga J, Männistö PT. Myöhänen TT, et al. Among authors: mannisto pt. J Histochem Cytochem. 2009 Sep;57(9):831-48. doi: 10.1369/jhc.2009.953711. Epub 2009 May 26. J Histochem Cytochem. 2009. PMID: 19687473 Free PMC article. Review.
372 results