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1995 1
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Focused ion beam-scanning electron microscopy links pathological myelin outfoldings to axonal changes in mice lacking Plp1 or Mag.
Steyer AM, Buscham TJ, Lorenz C, Hümmert S, Eichel-Vogel MA, Schadt LC, Edgar JM, Köster S, Möbius W, Nave KA, Werner HB. Steyer AM, et al. Glia. 2023 Mar;71(3):509-523. doi: 10.1002/glia.24290. Epub 2022 Nov 10. Glia. 2023. PMID: 36354016
The ultrastructure of CNS myelin requires specialized structural myelin proteins, including the transmembrane-tetraspan proteolipid protein (PLP) and the Ig-CAM myelin-associated glycoprotein (MAG). To better understand their functional relevance, we asked to what extent t …
The ultrastructure of CNS myelin requires specialized structural myelin proteins, including the transmembrane-tetraspan proteolipid protein …
A plausible contributor to multiple sclerosis; presentation of antigenic myelin protein epitopes by major histocompatibility complexes.
Jakhmola S, Sk MF, Chatterjee A, Jain K, Kar P, Jha HC. Jakhmola S, et al. Comput Biol Med. 2022 Sep;148:105856. doi: 10.1016/j.compbiomed.2022.105856. Epub 2022 Jul 14. Comput Biol Med. 2022. PMID: 35863244
Many herpes virus proteins like tegument, envelope glycoproteins, and ORFs of EBV, CMV, HHV-6, and HHV-8 demonstrated sequence similarity with MAG and PLP1. Some antigenic peptides were also linear B-cell epitopes and influenced cytokine production by T-cell. MHC I …
Many herpes virus proteins like tegument, envelope glycoproteins, and ORFs of EBV, CMV, HHV-6, and HHV-8 demonstrated sequence similarity wi …
Systemic infection exacerbates cerebrovascular dysfunction in Alzheimer's disease.
Asby D, Boche D, Allan S, Love S, Miners JS. Asby D, et al. Brain. 2021 Jul 28;144(6):1869-1883. doi: 10.1093/brain/awab094. Brain. 2021. PMID: 33723589 Free PMC article.
Several cytokines (IL-1beta, IL-6, TNF-alpha, IL-8 and IL-15) were further raised in Alzheimer's disease with systemic infection. Cerebral hypoperfusion-indicated by decreased MAG:PLP1 and increased vascular endothelial growth factor-A (VEGF)-and blood-brain barrier …
Several cytokines (IL-1beta, IL-6, TNF-alpha, IL-8 and IL-15) were further raised in Alzheimer's disease with systemic infection. Cerebral h …
Molecular differences in brain regional vulnerability to aging between males and females.
Zhou X, Cao J, Zhu L, Farrell K, Wang M, Guo L, Yang J, McKenzie A, Crary JF, Cai D, Tu Z, Zhang B. Zhou X, et al. Front Aging Neurosci. 2023 May 22;15:1153251. doi: 10.3389/fnagi.2023.1153251. eCollection 2023. Front Aging Neurosci. 2023. PMID: 37284017 Free PMC article.
In the cerebellar hemisphere, a myelination-associated module shared by males and females is driven by key regulators such as MOG, ENPP2, MYRF, ANLN, MAG and PLP1, which have been implicated in the development of AD and other neurodegenerative diseases. ...
In the cerebellar hemisphere, a myelination-associated module shared by males and females is driven by key regulators such as MOG, ENPP2, MY …
Pathophysiology of Hypoperfusion of the Precuneus in Early Alzheimer's Disease.
Miners JS, Palmer JC, Love S. Miners JS, et al. Brain Pathol. 2016 Jul;26(4):533-41. doi: 10.1111/bpa.12331. Epub 2015 Nov 9. Brain Pathol. 2016. PMID: 26452729 Free PMC article.
MAG:PLP1 was reduced 50% in early AD (Braak stage III-IV). Although MAG:PLP1 remained low in advanced AD (stage V-VI), the reduction was less pronounced, possibly reflecting falling oxygen demand. Reduction in cortical MAG:PLP1 correlated …
MAG:PLP1 was reduced 50% in early AD (Braak stage III-IV). Although MAG:PLP1 remained low in advanced AD (stage …
Is later-life depression a risk factor for Alzheimer's disease or a prodromal symptom: a study using post-mortem human brain tissue?
Sinclair LI, Mohr A, Morisaki M, Edmondson M, Chan S, Bone-Connaughton A, Turecki G, Love S. Sinclair LI, et al. Alzheimers Res Ther. 2023 Sep 12;15(1):153. doi: 10.1186/s13195-023-01299-2. Alzheimers Res Ther. 2023. PMID: 37700368 Free PMC article.
Levels of Abeta, phospho-tau and alpha-synuclein were assessed by immunohistochemistry and ELISA. To quantify chronic ischaemia, VEGF, MAG and PLP1 were measured by ELISA. To assess pericyte damage, PDGFRB was measured by ELISA. ...
Levels of Abeta, phospho-tau and alpha-synuclein were assessed by immunohistochemistry and ELISA. To quantify chronic ischaemia, VEGF, MA …
Mediators of cerebral hypoperfusion and blood-brain barrier leakiness in Alzheimer's disease, vascular dementia and mixed dementia.
Tayler H, Miners JS, Güzel Ö, MacLachlan R, Love S. Tayler H, et al. Brain Pathol. 2021 Jul;31(4):e12935. doi: 10.1111/bpa.12935. Epub 2021 Feb 25. Brain Pathol. 2021. PMID: 33410232 Free PMC article.
The ratio of myelin-associated glycoprotein to proteolipid protein-1 (MAG:PLP1), a post-mortem biochemical indicator of the adequacy of ante-mortem cerebral perfusion; the concentration of fibrinogen adjusted for haemoglobin level, a marker of blood-brain barrier (B …
The ratio of myelin-associated glycoprotein to proteolipid protein-1 (MAG:PLP1), a post-mortem biochemical indicator of the ad …
Oligodendroglial abnormalities in schizophrenia, mood disorders and substance abuse. Comorbidity, shared traits, or molecular phenocopies?
Sokolov BP. Sokolov BP. Int J Neuropsychopharmacol. 2007 Aug;10(4):547-55. doi: 10.1017/S1461145706007322. Epub 2007 Feb 12. Int J Neuropsychopharmacol. 2007. PMID: 17291372 Free article. Review.
Changes in oligodendroglia-related genes reported in SZ, BD and MDD appear to display considerable similarities (particularly decreased expression of MAG, ERBB, TF, PLP1, MOG, MOBP, MOG), while changes in cocaine abuse and alcoholism are more diverse. ...
Changes in oligodendroglia-related genes reported in SZ, BD and MDD appear to display considerable similarities (particularly decreased expr …
Possible Contribution of Altered Cholinergic Activity in the Visual Cortex in Visual Hallucinations in Parkinson's Disease.
Sinclair L, Brenton J, Liu AKL, MacLachlan R, Gentleman SM, Love S. Sinclair L, et al. J Neuropsychiatry Clin Neurosci. 2022 Spring;34(2):168-176. doi: 10.1176/appi.neuropsych.21040103. Epub 2021 Dec 28. J Neuropsychiatry Clin Neurosci. 2022. PMID: 34961331
Von Willebrand factor, vascular endothelial growth factor A, and myelin-associated glycoprotein:proteolipid protein-1 (MAG:PLP1) ratio-a measure of tissue oxygenation relative to metabolic demand, acetylcholinesterase (AChE), butyrylcholinesterase (BChE), choline ac …
Von Willebrand factor, vascular endothelial growth factor A, and myelin-associated glycoprotein:proteolipid protein-1 (MAG:PLP1 …
Ulk4 deficiency leads to hypomyelination in mice.
Liu M, Xu P, Guan Z, Qian X, Dockery P, Fitzgerald U, O'Brien T, Shen S. Liu M, et al. Glia. 2018 Jan;66(1):175-190. doi: 10.1002/glia.23236. Epub 2017 Oct 16. Glia. 2018. PMID: 29034508
Myelination is reduced by half in the Ulk4(tm1a/tm1a) hypomorph brain, whereas expression of axonal marker genes Tubb3, Nefh, Nefl and Nefm remains unaltered. Transcriptome analyses reveal that 8 (Gfap, Mbp, Mobp, Plp1, Slc1a2, Ttr, Cnp, Scd2) of the 10 most significantly …
Myelination is reduced by half in the Ulk4(tm1a/tm1a) hypomorph brain, whereas expression of axonal marker genes Tubb3, Nefh, Nefl and Nefm …
40 results