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46 results

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Page 1
MAP4K3/GLK in autoimmune disease, cancer and aging.
Chuang HC, Tan TH. Chuang HC, et al. J Biomed Sci. 2019 Oct 22;26(1):82. doi: 10.1186/s12929-019-0570-5. J Biomed Sci. 2019. PMID: 31640697 Free PMC article. Review.
GLK overexpression selectively promotes IL-17A transcription by inducing the AhR-RORgammat complex in T cells. In addition, GLK overexpression in cancer tissues is correlated with cancer recurrence of human lung cancer and liver cancer; the predictive …
GLK overexpression selectively promotes IL-17A transcription by inducing the AhR-RORgammat complex in T cells. In addition, GLK overexpressi …
MAP4K3/GLK Promotes Lung Cancer Metastasis by Phosphorylating and Activating IQGAP1.
Chuang HC, Chang CC, Teng CF, Hsueh CH, Chiu LL, Hsu PM, Lee MC, Hsu CP, Chen YR, Liu YC, Lyu PC, Tan TH. Chuang HC, et al. Cancer Res. 2019 Oct 1;79(19):4978-4993. doi: 10.1158/0008-5472.CAN-19-1402. Epub 2019 Aug 20. Cancer Res. 2019. PMID: 31431460
Overexpression of the serine/threonine kinase GLK/MAP4K3 in human lung cancer is associated with poor prognosis and recurrence, however, the role of GLK in cancer recurrence remains unclear. ...Collectively, GLK promotes lung cancer metastasis by bindi …
Overexpression of the serine/threonine kinase GLK/MAP4K3 in human lung cancer is associated with poor prognosis and recurrence …
Knockdown of circ-RAD23B inhibits non-small cell lung cancer progression via the miR-142-3p/MAP4K3 axis.
Zhuang Q, Huang Z, Zhuang W, Hong Y, Huang Y. Zhuang Q, et al. Thorac Cancer. 2022 Mar;13(5):750-760. doi: 10.1111/1759-7714.14319. Epub 2022 Feb 2. Thorac Cancer. 2022. PMID: 35106926 Free PMC article.
The predicted binding relationship between miR-142-3p and circ-RAD23B or MAP4K3 was verified by dual-luciferase reporter assay. The protein level of MAP4K3 was detected by western blot. ...Circ-RAD23B acted as miR-142-3p sponge to inhibit miR-142-3p expression and t …
The predicted binding relationship between miR-142-3p and circ-RAD23B or MAP4K3 was verified by dual-luciferase reporter assay. The p …
GLK/MAP4K3 overexpression associates with recurrence risk for non-small cell lung cancer.
Hsu CP, Chuang HC, Lee MC, Tsou HH, Lee LW, Li JP, Tan TH. Hsu CP, et al. Oncotarget. 2016 Jul 5;7(27):41748-41757. doi: 10.18632/oncotarget.9410. Oncotarget. 2016. PMID: 27203390 Free PMC article.
Lung cancer is the leading cause of cancer death worldwide. Non-small cell lung cancer (NSCLC) accounts for 85% of total lung cancers; 40% to 60% of NSCLC patients die of cancer recurrence after cancer resection. Since GLK (also named …
Lung cancer is the leading cause of cancer death worldwide. Non-small cell lung cancer (NSCLC) accounts for 85% of tota …
MicroRNA let-7c inhibits migration and invasion of human non-small cell lung cancer by targeting ITGB3 and MAP4K3.
Zhao B, Han H, Chen J, Zhang Z, Li S, Fang F, Zheng Q, Ma Y, Zhang J, Wu N, Yang Y. Zhao B, et al. Cancer Lett. 2014 Jan 1;342(1):43-51. doi: 10.1016/j.canlet.2013.08.030. Epub 2013 Aug 24. Cancer Lett. 2014. PMID: 23981581
We then analyzed the potential targets of let-7c and found that ITGB3 and MAP4K3 were directly repressed by let-7c. Upon restoring the expression of ITGB3 and MAP4K3, the effects of let-7c on tumor metastasis were partially reversed, and more importantly, the expres …
We then analyzed the potential targets of let-7c and found that ITGB3 and MAP4K3 were directly repressed by let-7c. Upon restoring th …
Baicalein suppresses growth of non-small cell lung carcinoma by targeting MAP4K3.
Li J, Yan L, Luo J, Tong L, Gao Y, Feng W, Wang F, Cui W, Li S, Sun Z. Li J, et al. Biomed Pharmacother. 2021 Jan;133:110965. doi: 10.1016/j.biopha.2020.110965. Epub 2020 Nov 6. Biomed Pharmacother. 2021. PMID: 33166766 Free article.
Subsequent in silico docking and mutation studies demonstrated that baicalein directly binds to MAP4K3, presumably to the substrate-binding pocket of this kinase domain, causing inactivity of MAP4K3. ...Degradation of MAP4K3 could cause dissociation of the tr …
Subsequent in silico docking and mutation studies demonstrated that baicalein directly binds to MAP4K3, presumably to the substrate-b …
PP2A T61 epsilon is an inhibitor of MAP4K3 in nutrient signaling to mTOR.
Yan L, Mieulet V, Burgess D, Findlay GM, Sully K, Procter J, Goris J, Janssens V, Morrice NA, Lamb RF. Yan L, et al. Mol Cell. 2010 Mar 12;37(5):633-42. doi: 10.1016/j.molcel.2010.01.031. Mol Cell. 2010. PMID: 20227368 Free article.
We identify a transautophosphorylation site in the MAP4K3 kinase activation segment (Ser170) that is required for MAP4K3 activity and its activation of mTORC1 signaling. ...We propose that during amino acid sufficiency Ser170-phosphorylated MAP4K3 activates m …
We identify a transautophosphorylation site in the MAP4K3 kinase activation segment (Ser170) that is required for MAP4K3 activ …
MicroRNA-98-5p regulates the proliferation and apoptosis of A549 cells by targeting MAP4K3.
Wang Z, Han Z, Zhang L, Zhang S, Wang B. Wang Z, et al. Oncol Lett. 2019 Oct;18(4):4288-4293. doi: 10.3892/ol.2019.10771. Epub 2019 Aug 22. Oncol Lett. 2019. PMID: 31579095 Free PMC article.
Non-small cell lung cancer (NSCLC) is a primary subtype of lung cancer that is accompanied by a high incidence rate and poor prognosis. ...MicroRNAs (miRs) serve important roles in multiple cancer types. In the current study, a decrease in miR-98-5p and an in …
Non-small cell lung cancer (NSCLC) is a primary subtype of lung cancer that is accompanied by a high incidence rate and poor p …
Drosophila happyhour modulates JNK-dependent apoptosis.
Lam D, Shah S, de Castro IP, Loh SH, Martins LM. Lam D, et al. Cell Death Dis. 2010 Aug 19;1(8):e66. doi: 10.1038/cddis.2010.44. Cell Death Dis. 2010. PMID: 21364671 Free PMC article.
We recently identified MAP4K3 as proapoptotic kinase using an RNA interference screening approach. In mammalian cells, MAP4K3 enhances the mitochondrial apoptosis pathway through the post-transcriptional modulation of selected proapoptotic Bcl-2 homology domain 3-on …
We recently identified MAP4K3 as proapoptotic kinase using an RNA interference screening approach. In mammalian cells, MAP4K3 …
MAP4K3 modulates cell death via the post-transcriptional regulation of BH3-only proteins.
Lam D, Dickens D, Reid EB, Loh SH, Moisoi N, Martins LM. Lam D, et al. Proc Natl Acad Sci U S A. 2009 Jul 21;106(29):11978-83. doi: 10.1073/pnas.0900608106. Epub 2009 Jul 8. Proc Natl Acad Sci U S A. 2009. PMID: 19587239 Free PMC article.
Using this approach, we identified MAP4K3 as a novel apoptosis inducer. Here, we present evidence that this pro-apoptotic kinase orchestrates activation of BAX via the concerted posttranscriptional modulation of PUMA, BAD, and BIM. Additionally, we found decreased levels o …
Using this approach, we identified MAP4K3 as a novel apoptosis inducer. Here, we present evidence that this pro-apoptotic kinase orch …
46 results