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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1998 1
1999 1
2000 2
2001 1
2002 2
2004 1
2005 2
2006 6
2007 6
2008 7
2009 12
2010 70
2011 141
2012 113
2013 137
2014 136
2015 146
2016 147
2017 167
2018 142
2019 139
2020 156
2021 150
2022 136
2023 110
2024 55

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1,709 results

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Page 1
MAPK1/3 kinase-dependent ULK1 degradation attenuates mitophagy and promotes breast cancer bone metastasis.
Deng R, Zhang HL, Huang JH, Cai RZ, Wang Y, Chen YH, Hu BX, Ye ZP, Li ZL, Mai J, Huang Y, Li X, Peng XD, Feng GK, Li JD, Tang J, Zhu XF. Deng R, et al. Autophagy. 2021 Oct;17(10):3011-3029. doi: 10.1080/15548627.2020.1850609. Epub 2020 Dec 7. Autophagy. 2021. PMID: 33213267 Free PMC article.
Also, a clearly negative correlation between the expression levels of ULK1 and p-MAPK1/3 was observed in human breast cancer tissues. The MAP2K/MEK inhibitor trametinib is sufficient to restore mitophagy function via upregulation of ULK1, leading to inhibition of NL …
Also, a clearly negative correlation between the expression levels of ULK1 and p-MAPK1/3 was observed in human breast cancer t …
The role of STAT3 in autophagy.
You L, Wang Z, Li H, Shou J, Jing Z, Xie J, Sui X, Pan H, Han W. You L, et al. Autophagy. 2015;11(5):729-39. doi: 10.1080/15548627.2015.1017192. Autophagy. 2015. PMID: 25951043 Free PMC article. Review.
Understanding the role of STAT3 signaling in the regulation of autophagy may provide insight into the classic autophagy model and also into cancer therapy, especially for the emerging targeted therapy, because a series of targeted agents execute antitumor activities via bl …
Understanding the role of STAT3 signaling in the regulation of autophagy may provide insight into the classic autophagy model and also into …
MAPK1 promotes the metastasis and invasion of gastric cancer as a bidirectional transcription factor.
Wang Y, Guo Z, Tian Y, Cong L, Zheng Y, Wu Z, Shan G, Xia Y, Zhu Y, Li X, Song Y. Wang Y, et al. BMC Cancer. 2023 Oct 10;23(1):959. doi: 10.1186/s12885-023-11480-3. BMC Cancer. 2023. PMID: 37817112 Free PMC article.
Previous studies have identified elevated expression of MAPK1 in human gastric cancer, which is associated with its role as a kinase, facilitating the migration and invasion of gastric cancer cells. However, how MAPK1 binds to its target genes as a tra …
Previous studies have identified elevated expression of MAPK1 in human gastric cancer, which is associated with its role as a …
A novel protein encoded by circMAPK1 inhibits progression of gastric cancer by suppressing activation of MAPK signaling.
Jiang T, Xia Y, Lv J, Li B, Li Y, Wang S, Xuan Z, Xie L, Qiu S, He Z, Wang L, Xu Z. Jiang T, et al. Mol Cancer. 2021 Apr 9;20(1):66. doi: 10.1186/s12943-021-01358-y. Mol Cancer. 2021. PMID: 33836754 Free PMC article.
The MAPK pathway is a common signal transduction pathway involved in cell proliferation, inflammation and apoptosis and plays a particularly important role in cancers. However, the role of circRNAs related to the MAPK pathway in gastric cancer has not been explored. …
The MAPK pathway is a common signal transduction pathway involved in cell proliferation, inflammation and apoptosis and plays a particularly …
GDF15 promotes the proliferation of cervical cancer cells by phosphorylating AKT1 and Erk1/2 through the receptor ErbB2.
Li S, Ma YM, Zheng PS, Zhang P. Li S, et al. J Exp Clin Cancer Res. 2018 Apr 10;37(1):80. doi: 10.1186/s13046-018-0744-0. J Exp Clin Cancer Res. 2018. PMID: 29636108 Free PMC article.
BACKGROUND: Growth differentiation factor 15 (GDF15) is a member of the TGF-beta superfamily, and evidence suggests that a substantial amount of GDF15 is secreted in various human cancers, such as ovarian cancer, prostate cancer, and breast cancer, amo …
BACKGROUND: Growth differentiation factor 15 (GDF15) is a member of the TGF-beta superfamily, and evidence suggests that a substantial amoun …
LINC00511 promotes cervical cancer progression by regulating the miR-497-5p/MAPK1 axis.
Lu M, Gao Q, Wang Y, Ren J, Zhang T. Lu M, et al. Apoptosis. 2022 Dec;27(11-12):800-811. doi: 10.1007/s10495-022-01768-3. Epub 2022 Sep 14. Apoptosis. 2022. PMID: 36103025 Free PMC article.
Our research was aimed at deciphering the role and mechanism of LINC00511 in the progression of cervical cancer (CC). METHOD: Quantitative real-time polymerase chain reaction (qRT-PCR) was performed to quantify the expression levels of LINC00511, miR-497-5p and MAPK1 …
Our research was aimed at deciphering the role and mechanism of LINC00511 in the progression of cervical cancer (CC). METHOD: Quantit …
circZFR regulates thyroid cancer progression by the miR-16/MAPK1 axis.
Xiong H, Yu H, Jia G, Yu J, Su Y, Zhang J, Zhou J. Xiong H, et al. Environ Toxicol. 2021 Nov;36(11):2236-2244. doi: 10.1002/tox.23337. Epub 2021 Jul 28. Environ Toxicol. 2021. PMID: 34323000
Previous studies have identified the dysregulation of various circRNAs in many types of human cancers including thyroid cancer (TC). Circular RNA ZFR (circZFR) serves as an oncogenic circRNA in TC. ...CircZFR inhibited miR-16 expression by sponging miR-16 and miR-16 …
Previous studies have identified the dysregulation of various circRNAs in many types of human cancers including thyroid cancer …
LncRNA LINC00483 promotes gastric cancer development through regulating MAPK1 expression by sponging miR-490-3p.
Luo M, Liang C. Luo M, et al. Biol Res. 2020 Apr 15;53(1):14. doi: 10.1186/s40659-020-00283-6. Biol Res. 2020. PMID: 32293550 Free PMC article.
RESULTS: LINC00483 and MAPK1 levels were increased in gastric cancer tissues and cells. ...Moreover, MAPK1 overexpression attenuated the effect of LINC00483 knockdown on gastric cancer development. ...
RESULTS: LINC00483 and MAPK1 levels were increased in gastric cancer tissues and cells. ...Moreover, MAPK1 overexpressi …
Suppression of MIR31HG affects the functional properties of thyroid cancer cells depending on the miR-761/MAPK1 axis.
Peng S, Chen L, Yuan Z, Duan S. Peng S, et al. BMC Endocr Disord. 2022 Apr 20;22(1):107. doi: 10.1186/s12902-022-00962-3. BMC Endocr Disord. 2022. PMID: 35443670 Free PMC article.
Moreover, miR-761 was identified as a molecular mediator of MIR30HG function in regulating thyroid cancer cell behaviors. MAPK1 was established as a direct and functional target of miR-761 and MAPK1 knockdown phenocopied miR-761 overexpression in impacting th …
Moreover, miR-761 was identified as a molecular mediator of MIR30HG function in regulating thyroid cancer cell behaviors. MAPK1 …
Tumor-suppressive miR-29c binds to MAPK1 inhibiting the ERK/MAPK pathway in pancreatic cancer.
Si H, Zhang N, Shi C, Luo Z, Hou S. Si H, et al. Clin Transl Oncol. 2023 Mar;25(3):803-816. doi: 10.1007/s12094-022-02991-9. Epub 2022 Dec 12. Clin Transl Oncol. 2023. PMID: 36510038
Effects of miR-29c/MAPK1 on tumorigenic ability in vivo were evaluated in pancreatic cancer xenografts in nude mice. ...CONCLUSIONS: Taken together, we unveil a novel miR-29c/MAPK1/ERK/MAPK axis that suppresses pancreatic cancer both in vitro and in vi …
Effects of miR-29c/MAPK1 on tumorigenic ability in vivo were evaluated in pancreatic cancer xenografts in nude mice. ...CONCLU …
1,709 results