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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1996 4
1997 1
1998 4
1999 12
2000 5
2001 15
2002 12
2003 19
2004 24
2005 13
2006 23
2007 29
2008 35
2009 44
2010 38
2011 22
2012 43
2013 48
2014 43
2015 43
2016 34
2017 46
2018 42
2019 46
2020 49
2021 44
2022 37
2023 43
2024 14

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724 results

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Page 1
Behind the Scene: Exploiting MC1R in Skin Cancer Risk and Prevention.
Manganelli M, Guida S, Ferretta A, Pellacani G, Porcelli L, Azzariti A, Guida G. Manganelli M, et al. Genes (Basel). 2021 Jul 19;12(7):1093. doi: 10.3390/genes12071093. Genes (Basel). 2021. PMID: 34356109 Free PMC article. Review.
Melanoma and non-melanoma skin cancers (NMSCs) are the most frequent cancers of the skin in white populations. An increased risk in the development of skin cancers has been associated with the combination of several environmental factors (i.e., ultraviolet ex …
Melanoma and non-melanoma skin cancers (NMSCs) are the most frequent cancers of the skin in white populations. An increased ri …
Palmitoylation-dependent activation of MC1R prevents melanomagenesis.
Chen S, Zhu B, Yin C, Liu W, Han C, Chen B, Liu T, Li X, Chen X, Li C, Hu L, Zhou J, Xu ZX, Gao X, Wu X, Goding CR, Cui R. Chen S, et al. Nature. 2017 Sep 21;549(7672):399-403. doi: 10.1038/nature23887. Epub 2017 Sep 6. Nature. 2017. PMID: 28869973 Free PMC article.
Here we demonstrate a potential MC1R-targeted intervention strategy in mice to rescue loss-of-function MC1R in MC1R RHC variants for therapeutic benefit by activating MC1R protein palmitoylation. ...Using C57BL/6J-Mc1r(e/e)J mice, in which endog …
Here we demonstrate a potential MC1R-targeted intervention strategy in mice to rescue loss-of-function MC1R in MC1R RHC …
UV radiation and the skin.
D'Orazio J, Jarrett S, Amaro-Ortiz A, Scott T. D'Orazio J, et al. Int J Mol Sci. 2013 Jun 7;14(6):12222-48. doi: 10.3390/ijms140612222. Int J Mol Sci. 2013. PMID: 23749111 Free PMC article. Review.
UV is epidemiologically and molecularly linked to the three most common types of skin cancer, basal cell carcinoma, squamous cell carcinoma and malignant melanoma, which together affect more than a million Americans annually. Genetic factors also influence risk of UV-media …
UV is epidemiologically and molecularly linked to the three most common types of skin cancer, basal cell carcinoma, squamous cell car …
Germline mutations predisposing to melanoma.
Toussi A, Mans N, Welborn J, Kiuru M. Toussi A, et al. J Cutan Pathol. 2020 Jul;47(7):606-616. doi: 10.1111/cup.13689. Epub 2020 May 11. J Cutan Pathol. 2020. PMID: 32249949 Free PMC article. Review.
CDKN2A mutations are responsible for the majority of hereditary melanoma, but many other susceptibility genes have been discovered in recent years, including CDK4, TERT, ACD, TERF2IP, POT1, MITF, MC1R, and BAP1. Additionally, melanoma risk is increased in mixed cancer …
CDKN2A mutations are responsible for the majority of hereditary melanoma, but many other susceptibility genes have been discovered in recent …
Development and validation of a five-immune gene prognostic risk model in colon cancer.
Chen H, Luo J, Guo J. Chen H, et al. BMC Cancer. 2020 May 6;20(1):395. doi: 10.1186/s12885-020-06799-0. BMC Cancer. 2020. PMID: 32375704 Free PMC article.
BACKGROUND: Colon cancer is a common and highly malignant cancer. Its morbidity is rapidly increasing, and its prognosis is poor. ...Besides, as the risk score increased, the content of CD8+ T cells in colon cancer was decreased. CONCLUSIONS: We developed and …
BACKGROUND: Colon cancer is a common and highly malignant cancer. Its morbidity is rapidly increasing, and its prognosis is po …
Ultraviolet Radiations: Skin Defense-Damage Mechanism.
Mohania D, Chandel S, Kumar P, Verma V, Digvijay K, Tripathi D, Choudhury K, Mitten SK, Shah D. Mohania D, et al. Adv Exp Med Biol. 2017;996:71-87. doi: 10.1007/978-3-319-56017-5_7. Adv Exp Med Biol. 2017. PMID: 29124692 Review.
UV-C has the property of ionization thus acting as a strong mutagen, which can cause immune-mediated disease and cancer in adverse cases. Numbers of genetic factors have been identified in human involved in inducing skin cancer from UV-radiations. ...In addition to …
UV-C has the property of ionization thus acting as a strong mutagen, which can cause immune-mediated disease and cancer in adverse ca …
Melanogenesis and the Targeted Therapy of Melanoma.
Li C, Kuai L, Cui R, Miao X. Li C, et al. Biomolecules. 2022 Dec 14;12(12):1874. doi: 10.3390/biom12121874. Biomolecules. 2022. PMID: 36551302 Free PMC article. Review.
Here, we reviewed the current available literatures on the mechanisms of melanogenesis, including the signaling pathways of UVR-induced pigment production, MC1R's central determinant roles and MITF as a master transcriptional regulator in melanogenesis. Moreover, we furthe …
Here, we reviewed the current available literatures on the mechanisms of melanogenesis, including the signaling pathways of UVR-induced pigm …
MC1R signaling through the cAMP-CREB/ATF-1 and ERK-NFkappaB pathways accelerates G1/S transition promoting breast cancer progression.
Chelakkot VS, Thomas K, Romigh T, Fong A, Li L, Ronen S, Chen S, Funchain P, Ni Y, Arbesman J. Chelakkot VS, et al. NPJ Precis Oncol. 2023 Sep 7;7(1):85. doi: 10.1038/s41698-023-00437-1. NPJ Precis Oncol. 2023. PMID: 37679505 Free PMC article.
Mechanistically, MC1R signaling through the MC1R-cAMP-CREB/ATF-1 and MC1R-ERK-NFkappaB axes accelerated the G1-S transition in breast cancer cells. Our results revealed a new association between MC1R and breast cancer, which could be pote …
Mechanistically, MC1R signaling through the MC1R-cAMP-CREB/ATF-1 and MC1R-ERK-NFkappaB axes accelerated the G1-S transi …
MC1R, eumelanin and pheomelanin: their role in determining the susceptibility to skin cancer.
Nasti TH, Timares L. Nasti TH, et al. Photochem Photobiol. 2015 Jan-Feb;91(1):188-200. doi: 10.1111/php.12335. Epub 2014 Nov 7. Photochem Photobiol. 2015. PMID: 25155575 Free PMC article. Review.
Persons with red hair have mutations in the MC1R causing its inactivation; this leads to a paucity of eumelanin production and makes red-heads more susceptible to skin cancer. ...This review will focus on the role of MC1R in terms of its regulation of melanog …
Persons with red hair have mutations in the MC1R causing its inactivation; this leads to a paucity of eumelanin production and makes …
MC1R Is a Prognostic Marker and Its Expression Is Correlated with MSI in Colorectal Cancer.
Peng L, Chang J, Liu X, Lu S, Ren H, Zhou X, Liu Z, Hu P. Peng L, et al. Curr Issues Mol Biol. 2021 Oct 11;43(3):1529-1547. doi: 10.3390/cimb43030108. Curr Issues Mol Biol. 2021. PMID: 34698109 Free PMC article.
A few studies have reported a relationship between MC1R and colorectal cancer (CRC). In this research, our objective was to examine MC1R expression and MC1R SNPs and investigate their correlation with the clinicopathological features of human CRC tissu …
A few studies have reported a relationship between MC1R and colorectal cancer (CRC). In this research, our objective was to ex …
724 results