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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1994 1
1995 3
1996 6
1997 8
1998 8
1999 24
2000 13
2001 32
2002 21
2003 41
2004 26
2005 31
2006 43
2007 56
2008 44
2009 72
2010 56
2011 48
2012 68
2013 92
2014 65
2015 74
2016 78
2017 79
2018 61
2019 63
2020 66
2021 64
2022 64
2023 60
2024 35

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1,252 results

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Page 1
Pig Coat Color Manipulation by MC1R Gene Editing.
Zhong H, Zhang J, Tan C, Shi J, Yang J, Cai G, Wu Z, Yang H. Zhong H, et al. Int J Mol Sci. 2022 Sep 8;23(18):10356. doi: 10.3390/ijms231810356. Int J Mol Sci. 2022. PMID: 36142269 Free PMC article.
Black coat color in pigs is determined by the dominant E allele at the MC1R locus. Through comparing MC1R gene sequences between recessive e and dominant E(D1) alleles, we identified four missense mutations that could affect MC1R protein function for e …
Black coat color in pigs is determined by the dominant E allele at the MC1R locus. Through comparing MC1R gene sequence …
Germline mutations predisposing to melanoma.
Toussi A, Mans N, Welborn J, Kiuru M. Toussi A, et al. J Cutan Pathol. 2020 Jul;47(7):606-616. doi: 10.1111/cup.13689. Epub 2020 May 11. J Cutan Pathol. 2020. PMID: 32249949 Free PMC article. Review.
Nearly 15% of melanomas occur in patients with a family history and a subset of these patients have a germline mutation in a melanoma predisposing gene. CDKN2A mutations are responsible for the majority of hereditary melanoma, but many other susceptibility genes hav …
Nearly 15% of melanomas occur in patients with a family history and a subset of these patients have a germline mutation in a melanoma predis …
Differential expression of MC1R gene in Liaoning Cashmere goats with different coat colors.
Li J, Chen W, Wu S, Ma T, Jiang H, Zhang Q. Li J, et al. Anim Biotechnol. 2019 Jul;30(3):273-278. doi: 10.1080/10495398.2018.1485681. Epub 2019 Jan 14. Anim Biotechnol. 2019. PMID: 30638122
Melanocyte stimulating hormone receptor (MC1R) has been known as a regulator of eumelanin and phaeomelanin production in the melanocytes, and MC1R mutations causing coat color changes are known in many vertebrates; however, there are no research reports about the di …
Melanocyte stimulating hormone receptor (MC1R) has been known as a regulator of eumelanin and phaeomelanin production in the melanocy …
Molecular characteristics of MC1R gene in tile-grey plumage of domestic chicken.
Zhang LY, Huang MY, Li Y, Yang XD, Luo YS, Shi XW. Zhang LY, et al. Br Poult Sci. 2020 Aug;61(4):382-389. doi: 10.1080/00071668.2020.1751804. Epub 2020 May 4. Br Poult Sci. 2020. PMID: 32264700
Through sequencing and comparison of the entire coding region of the MC1R gene, a total of 10 SNP loci were detected, of which eight were non-synonymous mutations that cause amino acid changes. ...Eighteen haplotypes of the MC1R gene were constructed b …
Through sequencing and comparison of the entire coding region of the MC1R gene, a total of 10 SNP loci were detected, of which …
Development and validation of a five-immune gene prognostic risk model in colon cancer.
Chen H, Luo J, Guo J. Chen H, et al. BMC Cancer. 2020 May 6;20(1):395. doi: 10.1186/s12885-020-06799-0. BMC Cancer. 2020. PMID: 32375704 Free PMC article.
The clinical utility of the model and its correlation with immune cell infiltration were analyzed. RESULTS: A total of 333 DE immune genes (176 up-regulated and 157 down-regulated) were detected. We developed and validated a five-immune gene model of colon cancer, i …
The clinical utility of the model and its correlation with immune cell infiltration were analyzed. RESULTS: A total of 333 DE immune gene …
The role of MC1R gene variants and phenotypical features in predicting high nevus count.
van der Poel LAJ, Bergman W, Gruis NA, Kukutsch NA. van der Poel LAJ, et al. Melanoma Res. 2020 Oct;30(5):511-514. doi: 10.1097/CMR.0000000000000687. Melanoma Res. 2020. PMID: 32732695
Variants in the Melanocortin 1 Receptor (MC1R) gene have been associated with an increased risk of melanoma, but the role in nevus count is unclear. We investigated if specific MC1R gene variants or the number of MC1R gene variants and ph …
Variants in the Melanocortin 1 Receptor (MC1R) gene have been associated with an increased risk of melanoma, but the role in n …
Mc1r gene in Astroblepus pholeter and Astyanax mexicanus: Convergent regressive evolution of pigmentation across cavefish species.
Espinasa L, Robinson J, Espinasa M. Espinasa L, et al. Dev Biol. 2018 Sep 15;441(2):305-310. doi: 10.1016/j.ydbio.2018.07.016. Epub 2018 Jul 19. Dev Biol. 2018. PMID: 30031757 Free article.
Thus, the Mc1r gene has been the repeated and independent location of mutations in Astyanax. ...A. pholeter displays mutations in ultra-conserved areas of the pigment-controlling gene, Mc1r, that have been linked to pigment regulation in other organism …
Thus, the Mc1r gene has been the repeated and independent location of mutations in Astyanax. ...A. pholeter displays mutations …
Single-cell profiling of MC1R-inhibited melanocytes.
Berns HM, Watkins-Chow DE, Lu S, Louphrasitthiphol P, Zhang T, Brown KM, Moura-Alves P, Goding CR, Pavan WJ. Berns HM, et al. Pigment Cell Melanoma Res. 2024 Mar;37(2):291-308. doi: 10.1111/pcmr.13141. Epub 2023 Nov 16. Pigment Cell Melanoma Res. 2024. PMID: 37972124
While MC1R variants have been established as causative of RHC and are a well-defined risk factor for melanoma, it remains unclear mechanistically why decreased MC1R signaling alters pigmentation and increases melanoma susceptibility. Here, we use single-cell RNA seq …
While MC1R variants have been established as causative of RHC and are a well-defined risk factor for melanoma, it remains unclear mec …
Piebaldism.
Oiso N, Fukai K, Kawada A, Suzuki T. Oiso N, et al. J Dermatol. 2013 May;40(5):330-5. doi: 10.1111/j.1346-8138.2012.01583.x. Epub 2012 Jun 1. J Dermatol. 2013. PMID: 22670867 Review.
Piebaldism is an uncommon autosomal dominantly inherited pigment anomaly characterized by a congenital white forelock and leukoderma on the frontal scalp, forehead, ventral trunk and extremities. It is caused by a loss-of-function mutation in the KIT gene. Genetic analyses …
Piebaldism is an uncommon autosomal dominantly inherited pigment anomaly characterized by a congenital white forelock and leukoderma on the …
MC1R, the cAMP pathway, and the response to solar UV: extending the horizon beyond pigmentation.
García-Borrón JC, Abdel-Malek Z, Jiménez-Cervantes C. García-Borrón JC, et al. Pigment Cell Melanoma Res. 2014 Sep;27(5):699-720. doi: 10.1111/pcmr.12257. Epub 2014 May 30. Pigment Cell Melanoma Res. 2014. PMID: 24807163 Free PMC article. Review.
Polymorphisms in the MC1R gene are a major source of normal variation of human hair color and skin pigmentation, response to ultraviolet radiation (UVR), and skin cancer susceptibility. ...We also review the current knowledge about the function of MC1R as a s …
Polymorphisms in the MC1R gene are a major source of normal variation of human hair color and skin pigmentation, response to u …
1,252 results