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156 results

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Page 1
Did you mean tcm and liver (3,070 results)?
Sensitive and specific multi-cancer detection and localization using methylation signatures in cell-free DNA.
Liu MC, Oxnard GR, Klein EA, Swanton C, Seiden MV; CCGA Consortium. Liu MC, et al. Ann Oncol. 2020 Jun;31(6):745-759. doi: 10.1016/j.annonc.2020.02.011. Epub 2020 Mar 30. Ann Oncol. 2020. PMID: 33506766 Free PMC article.
Stage I-III sensitivity was 67.3% (CI: 60.7% to 73.3%) in a pre-specified set of 12 cancer types (anus, bladder, colon/rectum, esophagus, head and neck, liver/bile-duct, lung, lymphoma, ovary, pancreas, plasma cell neoplasm, stomach), which account for 63% of US cancer dea …
Stage I-III sensitivity was 67.3% (CI: 60.7% to 73.3%) in a pre-specified set of 12 cancer types (anus, bladder, colon/rectum, esophagus, he …
Liver injury in cynomolgus monkeys following intravenous and intrathecal scAAV9 gene therapy delivery.
Hudry E, Aihara F, Meseck E, Mansfield K, McElroy C, Chand D, Tukov FF, Penraat K. Hudry E, et al. Mol Ther. 2023 Oct 4;31(10):2999-3014. doi: 10.1016/j.ymthe.2023.07.020. Epub 2023 Jul 28. Mol Ther. 2023. PMID: 37515322 Free article.
These transient acute liver injury marker elevations occur from 3-4 days post intravenous administration to 2 weeks post intrathecal administration. ...Co-administration of prednisolone after intravenous or intrathecal dosing did not prevent liver enzyme or microsco …
These transient acute liver injury marker elevations occur from 3-4 days post intravenous administration to 2 weeks post intrathecal …
TAT-MTS-MCM fusion proteins reduce MMA levels and improve mitochondrial activity and liver function in MCM-deficient cells.
Erlich-Hadad T, Hadad R, Feldman A, Greif H, Lictenstein M, Lorberboum-Galski H. Erlich-Hadad T, et al. J Cell Mol Med. 2018 Mar;22(3):1601-1613. doi: 10.1111/jcmm.13435. Epub 2017 Dec 19. J Cell Mol Med. 2018. PMID: 29265583 Free PMC article.
Liver or combined liver/kidney transplantation has been used to treat those with the most severe clinical manifestations. ...Treatment also enhanced albumin and urea secretion in a CRISPR/Cas9-engineered HepG2 MUT (-/-) liver cell line. Therefore, we suggest …
Liver or combined liver/kidney transplantation has been used to treat those with the most severe clinical manifestations. ...T …
Metabolic Communication by SGLT2 Inhibition.
Billing AM, Kim YC, Gullaksen S, Schrage B, Raabe J, Hutzfeldt A, Demir F, Kovalenko E, Lassé M, Dugourd A, Fallegger R, Klampe B, Jaegers J, Li Q, Kravtsova O, Crespo-Masip M, Palermo A, Fenton RA, Hoxha E, Blankenberg S, Kirchhof P, Huber TB, Laugesen E, Zeller T, Chrysopoulou M, Saez-Rodriguez J, Magnussen C, Eschenhagen T, Staruschenko A, Siuzdak G, Poulsen PL, Schwab C, Cuello F, Vallon V, Rinschen MM. Billing AM, et al. Circulation. 2024 Mar 12;149(11):860-884. doi: 10.1161/CIRCULATIONAHA.123.065517. Epub 2023 Dec 28. Circulation. 2024. PMID: 38152989 Free PMC article.
RESULTS: Kidneys of nondiabetic mice reacted most strongly to SGLT2i in terms of proteomic reconfiguration, including evidence for less early proximal tubule glucotoxicity and a broad downregulation of the apical uptake transport machinery (including sodium, glucose, urate, purin …
RESULTS: Kidneys of nondiabetic mice reacted most strongly to SGLT2i in terms of proteomic reconfiguration, including evidence for less earl …
Racial and Ethnic Disparities in Liver Transplantation for Alcohol-associated Liver Diseases in the United States.
Cotter TG, Mitchell MC, Patel MJ, Anouti A, Lieber SR, Rich NE, Arab JP, Díaz LA, Louissaint J, Kerr T, Mufti AR, Hanish SI, Vagefi PA, Patel MS, VanWagner LB, Lee WM, O'Leary JG, Singal AG. Cotter TG, et al. Transplantation. 2024 Jan 1;108(1):225-234. doi: 10.1097/TP.0000000000004701. Epub 2023 Jun 21. Transplantation. 2024. PMID: 37340542
BACKGROUND: Emerging data suggest disparities exist in liver transplantation (LT) for alcohol-associated liver disease (ALD). ...
BACKGROUND: Emerging data suggest disparities exist in liver transplantation (LT) for alcohol-associated liver disease (ALD). …
Identification of MCM family as potential therapeutic and prognostic targets for hepatocellular carcinoma based on bioinformatics and experiments.
Lei Y, Wang S, Liu J, Yan W, Han P, Tian D. Lei Y, et al. Life Sci. 2021 May 1;272:119227. doi: 10.1016/j.lfs.2021.119227. Epub 2021 Feb 16. Life Sci. 2021. PMID: 33607151
AIMS: The minichromosome maintenance (MCM) complex is highly conserved, which has drawn increasing attention on physiology and pathology process. However, the role of MCM in hepatocellular carcinoma (HCC) remains largely unclear. We aimed to conduct systematic analy …
AIMS: The minichromosome maintenance (MCM) complex is highly conserved, which has drawn increasing attention on physiology and pathol …
Krill Oil Treatment Increases Distinct PUFAs and Oxylipins in Adipose Tissue and Liver and Attenuates Obesity-Associated Inflammation via Direct and Indirect Mechanisms.
Gart E, Salic K, Morrison MC, Caspers M, van Duyvenvoorde W, Heijnk M, Giera M, Bobeldijk-Pastorova I, Keijer J, Storsve AB, Hals PA, Kleemann R. Gart E, et al. Nutrients. 2021 Aug 18;13(8):2836. doi: 10.3390/nu13082836. Nutrients. 2021. PMID: 34444996 Free PMC article.
The HFD with KrO was compared to an HFD control group to evaluate the effects on fatty acid composition and associated inflammation in epididymal white adipose tissue (eWAT) and the liver during obesity development. KrO treatment increased the concentrations of EPA and DHA …
The HFD with KrO was compared to an HFD control group to evaluate the effects on fatty acid composition and associated inflammation in epidi …
MCM family in HCC: MCM6 indicates adverse tumor features and poor outcomes and promotes S/G2 cell cycle progression.
Liu Z, Li J, Chen J, Shan Q, Dai H, Xie H, Zhou L, Xu X, Zheng S. Liu Z, et al. BMC Cancer. 2018 Feb 20;18(1):200. doi: 10.1186/s12885-018-4056-8. BMC Cancer. 2018. PMID: 29463213 Free PMC article. Review.
METHODS: MCMs were analyzed in 105 samples including normal livers (n = 15), cirrhotic livers (n = 40), HCC (n = 50) using quantitative polymerase chain reaction (qPCR) (Cohort 1). Significantly up-regulated MCMs were verified in 102 HCC and matched peritumoral l …
METHODS: MCMs were analyzed in 105 samples including normal livers (n = 15), cirrhotic livers (n = 40), HCC (n = 50) using qua …
MCMs in Cancer: Prognostic Potential and Mechanisms.
Yu S, Wang G, Shi Y, Xu H, Zheng Y, Chen Y. Yu S, et al. Anal Cell Pathol (Amst). 2020 Feb 3;2020:3750294. doi: 10.1155/2020/3750294. eCollection 2020. Anal Cell Pathol (Amst). 2020. PMID: 32089988 Free PMC article. Review.
This review provides an overview of the significant findings regarding the cellular and tumorigenic functions of the MCM family. Besides, current evidence of the prognostic roles of MCMs is retrospectively reviewed. This work also offers insight into the mechanisms of MCMs …
This review provides an overview of the significant findings regarding the cellular and tumorigenic functions of the MCM family. Besi …
Myofibroblast-specific YY1 promotes liver fibrosis.
Liu H, Zhang S, Xu S, Koroleva M, Small EM, Jin ZG. Liu H, et al. Biochem Biophys Res Commun. 2019 Jun 30;514(3):913-918. doi: 10.1016/j.bbrc.2019.05.004. Epub 2019 May 10. Biochem Biophys Res Commun. 2019. PMID: 31084931 Free PMC article.
Liver fibrosis is a common consequence of various chronic hepatitis and liver injuries. ...Using tamoxifen inducible myofibroblast-specific Cre-expressing mouse lines with selective deletion of the transcription factor Yin Yang 1 (YY1), here we show that YY1 deletio …
Liver fibrosis is a common consequence of various chronic hepatitis and liver injuries. ...Using tamoxifen inducible myofibrob …
156 results