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Year Number of Results
2007 2
2009 1
2010 2
2011 1
2016 1
2017 2
2018 4
2019 1
2020 2
2021 3
2024 0

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Page 1
Inhibition of WEE1 Is Effective in TP53- and RAS-Mutant Metastatic Colorectal Cancer: A Randomized Trial (FOCUS4-C) Comparing Adavosertib (AZD1775) With Active Monitoring.
Seligmann JF, Fisher DJ, Brown LC, Adams RA, Graham J, Quirke P, Richman SD, Butler R, Domingo E, Blake A, Yates E, Braun M, Collinson F, Jones R, Brown E, de Winton E, Humphrey TC, Parmar M, Kaplan R, Wilson RH, Seymour M, Maughan TS; FOCUS4 Trial Investigators. Seligmann JF, et al. J Clin Oncol. 2021 Nov 20;39(33):3705-3715. doi: 10.1200/JCO.21.01435. Epub 2021 Sep 18. J Clin Oncol. 2021. PMID: 34538072 Free PMC article. Clinical Trial.
Expression of the cancer-associated DNA polymerase ε P286R in fission yeast leads to translesion synthesis polymerase dependent hypermutation and defective DNA replication.
Soriano I, Vazquez E, De Leon N, Bertrand S, Heitzer E, Toumazou S, Bo Z, Palles C, Pai CC, Humphrey TC, Tomlinson I, Cotterill S, Kearsey SE. Soriano I, et al. PLoS Genet. 2021 Jul 6;17(7):e1009526. doi: 10.1371/journal.pgen.1009526. eCollection 2021 Jul. PLoS Genet. 2021. PMID: 34228709 Free PMC article.
An essential role for dNTP homeostasis following CDK-induced replication stress.
Pai CC, Hsu KF, Durley SC, Keszthelyi A, Kearsey SE, Rallis C, Folkes LK, Deegan R, Wilkins SE, Pfister SX, De León N, Schofield CJ, Bähler J, Carr AM, Humphrey TC. Pai CC, et al. J Cell Sci. 2019 Mar 25;132(6):jcs226969. doi: 10.1242/jcs.226969. J Cell Sci. 2019. PMID: 30674555 Free PMC article.
DNA Double-Strand Break Repair Assay.
Pai CC, Blaikley E, Humphrey TC. Pai CC, et al. Cold Spring Harb Protoc. 2018 Apr 2;2018(4). doi: 10.1101/pdb.prot092031. Cold Spring Harb Protoc. 2018. PMID: 28733408
Analysis of DNA Metabolism in Fission Yeast.
Antequera F, Humphrey TC. Antequera F, et al. Cold Spring Harb Protoc. 2018 Apr 2;2018(4). doi: 10.1101/pdb.top079863. Cold Spring Harb Protoc. 2018. PMID: 28733402
18 results