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329 results

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Page 1
Roles for MDC1 in cancer development and treatment.
Ruff SE, Logan SK, Garabedian MJ, Huang TT. Ruff SE, et al. DNA Repair (Amst). 2020 Nov;95:102948. doi: 10.1016/j.dnarep.2020.102948. Epub 2020 Aug 11. DNA Repair (Amst). 2020. PMID: 32866776 Free PMC article. Review.
This includes MDC1 functioning as a tumor suppressor, with its loss serving as a biomarker for cancer and contributor to drug sensitivity. ...This review will discuss reports that link MDC1 to cancer and identify MDC1 as an important player in t …
This includes MDC1 functioning as a tumor suppressor, with its loss serving as a biomarker for cancer and contributor to drug …
Functional defects of cancer-associated MDC1 mutations in DNA damage repair.
Xie R, Yan Z, Jing J, Wang Y, Zhang J, Li Y, Liu X, Yu X, Wu C. Xie R, et al. DNA Repair (Amst). 2022 Jun;114:103330. doi: 10.1016/j.dnarep.2022.103330. Epub 2022 Apr 21. DNA Repair (Amst). 2022. PMID: 35378404
In cancers, genomic instability results from mutations in DNA repair genes and drives cancer development. ...Here, we summarized cancer-associated mutations of MDC1 including insertion/deletion mutations as well as missense mutations in key functional …
In cancers, genomic instability results from mutations in DNA repair genes and drives cancer development. ...Here, we summariz …
DNA damage response signaling pathways and targets for radiotherapy sensitization in cancer.
Huang RX, Zhou PK. Huang RX, et al. Signal Transduct Target Ther. 2020 May 1;5(1):60. doi: 10.1038/s41392-020-0150-x. Signal Transduct Target Ther. 2020. PMID: 32355263 Free PMC article. Review.
Radiotherapy is one of the most common countermeasures for treating a wide range of tumors. However, the radioresistance of cancer cells is still a major limitation for radiotherapy applications. ...We further discuss recent advances identified from preclinical studies, cu …
Radiotherapy is one of the most common countermeasures for treating a wide range of tumors. However, the radioresistance of cancer ce …
MDC1 promotes ovarian cancer metastasis by inducing epithelial-mesenchymal transition.
Liu X, Dong R, Jiang Z, Wei Y, Li Y, Wei L, Sun H, Li Y, Yang N, Yang Q, Liu Z, Kong B. Liu X, et al. Tumour Biol. 2015 Jun;36(6):4261-9. doi: 10.1007/s13277-015-3063-5. Epub 2015 Jan 16. Tumour Biol. 2015. PMID: 25592380
Furthermore, MDC1 overexpression in ovarian cancer cells significantly increased migration and invasion. ...Taken together, our findings suggest that MDC1 promotes ovarian cancer metastasis through the induction of EMT....
Furthermore, MDC1 overexpression in ovarian cancer cells significantly increased migration and invasion. ...Taken together, ou …
MDC1 maintains active elongation complexes of RNA polymerase II.
Pappas G, Munk SHN, Watanabe K, Thomas Q, Gál Z, Gram HH, Lee M, Gómez-Cabello D, Kanellis DC, Olivares-Chauvet P, Larsen DH, Gregersen LH, Maya-Mendoza A, Galanos P, Bartek J. Pappas G, et al. Cell Rep. 2023 Jan 31;42(1):111979. doi: 10.1016/j.celrep.2022.111979. Epub 2023 Jan 12. Cell Rep. 2023. PMID: 36640322 Free article.
Of clinical relevance, cancer cells lacking MDC1 display hypersensitivity to RNAPII inhibitors. Overall, we unveil a role of MDC1 in RNAPII-mediated transcription with potential implications for cancer treatment....
Of clinical relevance, cancer cells lacking MDC1 display hypersensitivity to RNAPII inhibitors. Overall, we unveil a role of …
MDC1 depletion promotes cisplatin induced cell death in cervical cancer cells.
Singh N, Bhakuni R, Chhabria D, Kirubakaran S. Singh N, et al. BMC Res Notes. 2020 Mar 11;13(1):146. doi: 10.1186/s13104-020-04996-5. BMC Res Notes. 2020. PMID: 32160908 Free PMC article.
In this regard, we investigated the effect of MDC1 change in expression on the cisplatin sensitivity in cervical cancer cells. ...Further, we observed the increased p53 Ser 15 phosphorylation in the MDC1 depleted cells. Our studies suggest that MDC1 ex …
In this regard, we investigated the effect of MDC1 change in expression on the cisplatin sensitivity in cervical cancer cells. …
AP4 suppresses DNA damage, chromosomal instability and senescence via inducing MDC1/Mediator of DNA damage Checkpoint 1 and repressing MIR22HG/miR-22-3p.
Chou J, Kaller M, Jaeckel S, Rokavec M, Hermeking H. Chou J, et al. Mol Cancer. 2022 May 27;21(1):120. doi: 10.1186/s12943-022-01581-1. Mol Cancer. 2022. PMID: 35624466 Free PMC article.
Accordingly, MDC1 was directly induced by AP4 and indirectly by AP4-mediated repression of miR-22-3p. ...These findings explain how elevated AP4 expression contributes to development and chemo-resistance of colorectal cancer after c-MYC activation....
Accordingly, MDC1 was directly induced by AP4 and indirectly by AP4-mediated repression of miR-22-3p. ...These findings explain how e …
MDC1 Enhances Estrogen Receptor-mediated Transactivation and Contributes to Breast Cancer Suppression.
Zou R, Zhong X, Wang C, Sun H, Wang S, Lin L, Sun S, Tong C, Luo H, Gao P, Li Y, Zhou T, Li D, Cao L, Zhao Y. Zou R, et al. Int J Biol Sci. 2015 Jul 3;11(9):992-1005. doi: 10.7150/ijbs.10918. eCollection 2015. Int J Biol Sci. 2015. PMID: 26221067 Free PMC article.
In this study, we have identified MDC1 as a co-activator of ERalpha in breast cancer cells and demonstrated that MDC1 associates with ERalpha. ...MDC1 depletion led to the promotion of breast cancer progression, and the expression of MDC1 …
In this study, we have identified MDC1 as a co-activator of ERalpha in breast cancer cells and demonstrated that MDC1 a …
Long non-coding RNA MDC1-AS inhibits human gastric cancer cell proliferation and metastasis through an MDC1-dependent mechanism.
Qin Y, Zhuang S, Wen J, Zheng K. Qin Y, et al. Exp Ther Med. 2018 Jan;15(1):191-197. doi: 10.3892/etm.2017.5370. Epub 2017 Oct 24. Exp Ther Med. 2018. PMID: 29375682 Free PMC article.
The present study aimed to explore the role of the LncRNA mediator of DNA damage checkpoint protein 1-antisense RNA (MDC1-AS), the antisense transcript of MDC1, in human gastric cancer. The results revealed that the expression of MDC1-AS in human gastr …
The present study aimed to explore the role of the LncRNA mediator of DNA damage checkpoint protein 1-antisense RNA (MDC1-AS), the an …
A Novel Targeted Therapy System for Cervical Cancer: Co-Delivery System of Antisense LncRNA of MDC1 and Oxaliplatin Magnetic Thermosensitive Cationic Liposome Drug Carrier.
Ye H, Chu X, Cao Z, Hu X, Wang Z, Li M, Wan L, Li Y, Cao Y, Diao Z, Peng F, Liu J, Xu L. Ye H, et al. Int J Nanomedicine. 2021 Feb 11;16:1051-1066. doi: 10.2147/IJN.S258316. eCollection 2021. Int J Nanomedicine. 2021. PMID: 33603368 Free PMC article.
BACKGROUND: This study was aimed to prepare a novel magnetic thermosensitive cationic liposome drug carrier for the codelivery of Oxaliplatin (OXA) and antisense lncRNA of MDC1 (MDC1-AS) to Cervical cancer cells and evaluate the efficiency of this drug carrie …
BACKGROUND: This study was aimed to prepare a novel magnetic thermosensitive cationic liposome drug carrier for the codelivery of Oxaliplati …
329 results