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2004 2
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48 results

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MDN1 Mutation Is Associated With High Tumor Mutation Burden and Unfavorable Prognosis in Breast Cancer.
Hao S, Huang M, Xu X, Wang X, Huo L, Wang L, Gu J. Hao S, et al. Front Genet. 2022 Mar 21;13:857836. doi: 10.3389/fgene.2022.857836. eCollection 2022. Front Genet. 2022. PMID: 35386280 Free PMC article.

Compared to the MDN1 wild-type patients, the TMB value was significantly higher in MDN1 mutant patients (p < 0.001). Prognostic analysis revealed that MDN1 mutant patients had a worse survival probability than MDN1 wild-type patients (hazard ratio =

…

Compared to the MDN1 wild-type patients, the TMB value was significantly higher in MDN1 mutant patients (p < 0.001). Progno

…
An improved MS2 system for accurate reporting of the mRNA life cycle.
Tutucci E, Vera M, Biswas J, Garcia J, Parker R, Singer RH. Tutucci E, et al. Nat Methods. 2018 Jan;15(1):81-89. doi: 10.1038/nmeth.4502. Epub 2017 Nov 13. Nat Methods. 2018. PMID: 29131164 Free PMC article.
Here, we describe a reporter system (MBSV6) with reduced affinity for the MCP, which allows mRNA degradation while preserving single-molecule detection determined by single-molecule FISH (smFISH) or live imaging. Constitutive mRNAs (MDN1 and DOA1) and highly-regulated mRNA …
Here, we describe a reporter system (MBSV6) with reduced affinity for the MCP, which allows mRNA degradation while preserving single-molecul …
Arabidopsis MDN1 Is Involved in the Establishment of a Normal Seed Proteome and Seed Germination.
Li PC, Ma JJ, Zhou XM, Li GH, Zhao CZ, Xia H, Fan SJ, Wang XJ. Li PC, et al. Front Plant Sci. 2019 Sep 10;10:1118. doi: 10.3389/fpls.2019.01118. eCollection 2019. Front Plant Sci. 2019. PMID: 31552080 Free PMC article.
In this study, we further found that the weak mutant of MDN1, mdn1-1, exhibits an increased seed size phenotype. Seed proteomic analysis reveals that a number of proteins involved in seed development and response to external environments are mis-regulated by the …
In this study, we further found that the weak mutant of MDN1, mdn1-1, exhibits an increased seed size phenotype. Seed proteomi …
The MIDAS domain of AAA mechanoenzyme Mdn1 forms catch bonds with two different substrates.
Mickolajczyk KJ, Olinares PDB, Chait BT, Liu S, Kapoor TM. Mickolajczyk KJ, et al. Elife. 2022 Feb 11;11:e73534. doi: 10.7554/eLife.73534. Elife. 2022. PMID: 35147499 Free PMC article.
Parallel experiments with Rsa4 and Ytm1 show that forces up to ~4 pN, matching the magnitude of force produced by AAA proteins similar to Mdn1, enhance the MIDAS domain binding lifetime up to 10-fold, and higher forces accelerate dissociation. Together, our studies indicat …
Parallel experiments with Rsa4 and Ytm1 show that forces up to ~4 pN, matching the magnitude of force produced by AAA proteins similar to …
Structural Insights into Mdn1, an Essential AAA Protein Required for Ribosome Biogenesis.
Chen Z, Suzuki H, Kobayashi Y, Wang AC, DiMaio F, Kawashima SA, Walz T, Kapoor TM. Chen Z, et al. Cell. 2018 Oct 18;175(3):822-834.e18. doi: 10.1016/j.cell.2018.09.015. Epub 2018 Oct 11. Cell. 2018. PMID: 30318141 Free PMC article.
Mdn1 is an essential AAA (ATPase associated with various activities) protein that removes assembly factors from distinct precursors of the ribosomal 60S subunit. ...Here, we present structures for S. pombe Mdn1 in the presence of AMPPNP at up to 4 A or ATP plus Rbin …
Mdn1 is an essential AAA (ATPase associated with various activities) protein that removes assembly factors from distinct precursors o …
The AAA ATPase MDN1 Acts as a SUMO-Targeted Regulator in Mammalian Pre-ribosome Remodeling.
Raman N, Weir E, Müller S. Raman N, et al. Mol Cell. 2016 Nov 3;64(3):607-615. doi: 10.1016/j.molcel.2016.09.039. Mol Cell. 2016. PMID: 27814492 Free article.
Here we show that SUMO conjugation/deconjugation of PELP1 controls its dynamic association with the AAA ATPase MDN1, a key factor of pre-60S remodeling. We demonstrate that modification of PELP1 promotes the recruitment of MDN1 to pre-60S particles, while deSUMOylat …
Here we show that SUMO conjugation/deconjugation of PELP1 controls its dynamic association with the AAA ATPase MDN1, a key factor of …
Long-range intramolecular allostery and regulation in the dynein-like AAA protein Mdn1.
Mickolajczyk KJ, Olinares PDB, Niu Y, Chen N, Warrington SE, Sasaki Y, Walz T, Chait BT, Kapoor TM. Mickolajczyk KJ, et al. Proc Natl Acad Sci U S A. 2020 Aug 4;117(31):18459-18469. doi: 10.1073/pnas.2002792117. Epub 2020 Jul 21. Proc Natl Acad Sci U S A. 2020. PMID: 32694211 Free PMC article.
Mdn1 is an essential mechanoenzyme that uses the energy from ATP hydrolysis to physically reshape and remodel, and thus mature, the 60S subunit of the ribosome. ...Here, we use chemical probes, single-particle electron microscopy, and native mass spectrometry to study the …
Mdn1 is an essential mechanoenzyme that uses the energy from ATP hydrolysis to physically reshape and remodel, and thus mature, the 6 …
Coordination between MIDASIN 1-mediated ribosome biogenesis and auxin modulates plant development.
Li K, Zhou X, Sun X, Li G, Hou L, Zhao S, Zhao C, Ma C, Li P, Wang X. Li K, et al. J Exp Bot. 2021 Mar 29;72(7):2501-2513. doi: 10.1093/jxb/erab025. J Exp Bot. 2021. PMID: 33476386
In this study, we further characterized the aberrant auxin-related phenotypes of mdn1-1, a weak mutant allele of MDN1. Auxin response is disturbed in both shoots and roots of mdn1-1, as indicated by the DR5:GUS reporter. By combining transcriptome profiling a …
In this study, we further characterized the aberrant auxin-related phenotypes of mdn1-1, a weak mutant allele of MDN1. Auxin r …
Mutation of an Essential 60S Ribosome Assembly Factor MIDASIN 1 Induces Early Flowering in Arabidopsis.
Li K, Wang P, Ding T, Hou L, Li G, Zhao C, Zhao S, Wang X, Li P. Li K, et al. Int J Mol Sci. 2022 Jun 10;23(12):6509. doi: 10.3390/ijms23126509. Int J Mol Sci. 2022. PMID: 35742952 Free PMC article.
However, the early-flowering phenotype resulting from the ribosome biogenesis defect is rarely reported. We previously identified that the AAA-ATPase MIDASIN 1 (MDN1) functions as a 60S RBF in Arabidopsis. Here, we found that its weak mutant mdn1-1 is early-flowerin …
However, the early-flowering phenotype resulting from the ribosome biogenesis defect is rarely reported. We previously identified that the A …
The AAA-ATPase MIDASIN 1 Functions in Ribosome Biogenesis and Is Essential for Embryo and Root Development.
Li PC, Li K, Wang J, Zhao CZ, Zhao SZ, Hou L, Xia H, Ma CL, Wang XJ. Li PC, et al. Plant Physiol. 2019 May;180(1):289-304. doi: 10.1104/pp.18.01225. Epub 2019 Feb 12. Plant Physiol. 2019. PMID: 30755475 Free PMC article.
Here, we showed that the Arabidopsis null mutant of MDN1 is embryo-lethal. Using the weak mutant mdn1-1, which maintains viability, we found that MDN1 is critical for the regular pattern of auxin maxima in the globular embryo and functions in root meristem ma …
Here, we showed that the Arabidopsis null mutant of MDN1 is embryo-lethal. Using the weak mutant mdn1-1, which maintains viabi …
48 results