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Page 1
MECOM Deficiency: from Bone Marrow Failure to Impaired B-Cell Development.
Voit RA, Sankaran VG. Voit RA, et al. J Clin Immunol. 2023 Aug;43(6):1052-1066. doi: 10.1007/s10875-023-01545-0. Epub 2023 Jul 5. J Clin Immunol. 2023. PMID: 37407873 Review.
MECOM deficiency is a recently identified inborn error of immunity and inherited bone marrow failure syndrome caused by haploinsufficiency of the hematopoietic transcription factor MECOM. ...Heterozygous mutations, as seen in MECOM-deficient bone marrow failu …
MECOM deficiency is a recently identified inborn error of immunity and inherited bone marrow failure syndrome caused by haploinsuffic …
PAX8 and MECOM are interaction partners driving ovarian cancer.
Bleu M, Mermet-Meillon F, Apfel V, Barys L, Holzer L, Bachmann Salvy M, Lopes R, Amorim Monteiro Barbosa I, Delmas C, Hinniger A, Chau S, Kaufmann M, Haenni S, Berneiser K, Wahle M, Moravec I, Vissières A, Poetsch T, Ahrné E, Carte N, Voshol J, Bechter E, Hamon J, Meyerhofer M, Erdmann D, Fischer M, Stachyra T, Freuler F, Gutmann S, Fernández C, Schmelzle T, Naumann U, Roma G, Lawrenson K, Nieto-Oberhuber C, Cobos-Correa A, Ferretti S, Schübeler D, Galli GG. Bleu M, et al. Nat Commun. 2021 Apr 26;12(1):2442. doi: 10.1038/s41467-021-22708-w. Nat Commun. 2021. PMID: 33903593 Free PMC article.
At a subset of these, PAX8 together with PRDM3 regulates a specific gene expression module involved in adhesion and extracellular matrix. This gene module correlates with PAX8 and MECOM expression in large scale profiling of cell lines, patient-derived xenografts (PDXs) an …
At a subset of these, PAX8 together with PRDM3 regulates a specific gene expression module involved in adhesion and extracellular matrix. Th …
MECOM gene overexpression in pediatric patients with acute myeloid leukemia.
Elsherif M, Hammad M, Hafez H, Yassin D, Ashraf M, Yasser N, Lehmann L, Elhaddad A. Elsherif M, et al. Acta Oncol. 2022 Apr;61(4):516-522. doi: 10.1080/0284186X.2022.2025611. Epub 2022 Jan 17. Acta Oncol. 2022. PMID: 35038958
PATIENTS AND METHODS: Real-time quantitative polymerase chain reaction and Livak method (2(deltadeltaCt)) were used to determine relative MECOM expression level among 243 pediatric patients with AML. MECOM overexpression was considered if the cumulative relative exp …
PATIENTS AND METHODS: Real-time quantitative polymerase chain reaction and Livak method (2(deltadeltaCt)) were used to determine relative …
CRISPR-mediated MECOM depletion retards tumor growth by reducing cancer stem cell properties in lung squamous cell carcinoma.
Ma Y, Kang B, Li S, Xie G, Bi J, Li F, An G, Liu B, Li J, Shen Y, Xu X, Yang H, Yang Y, Gu Y, Wu N. Ma Y, et al. Mol Ther. 2022 Nov 2;30(11):3341-3357. doi: 10.1016/j.ymthe.2022.06.011. Epub 2022 Jun 22. Mol Ther. 2022. PMID: 35733338 Free PMC article.
Targeted therapy for lung squamous cell carcinoma (LUSC) remains a challenge due to the lack of robust targets. Here, we identified MECOM as a candidate of therapeutic target for LUSC by screening 38 genes that were commonly amplified in three pairs of primary tumors and p …
Targeted therapy for lung squamous cell carcinoma (LUSC) remains a challenge due to the lack of robust targets. Here, we identified MECOM …
Epigenetic landscape reveals MECOM as an endothelial lineage regulator.
Lv J, Meng S, Gu Q, Zheng R, Gao X, Kim JD, Chen M, Xia B, Zuo Y, Zhu S, Zhao D, Li Y, Wang G, Wang X, Meng Q, Cao Q, Cooke JP, Fang L, Chen K, Zhang L. Lv J, et al. Nat Commun. 2023 Apr 25;14(1):2390. doi: 10.1038/s41467-023-38002-w. Nat Commun. 2023. PMID: 37185814 Free PMC article.
Our experiments demonstrate that MECOM depletion impairs human endothelial cell differentiation, functions, and Zebrafish angiogenesis. ...Further, we identify and verify the VEGF signaling pathway to be a key target of MECOM. Our work provides important insights in …
Our experiments demonstrate that MECOM depletion impairs human endothelial cell differentiation, functions, and Zebrafish angiogenesi …
A distal super-enhancer activates oncogenic ETS2 via recruiting MECOM in inflammatory bowel disease and colorectal cancer.
Chen Y, Ying Y, Wang M, Ma C, Jia M, Shi L, Wang S, Zheng X, Chen W, Shu XS. Chen Y, et al. Cell Death Dis. 2023 Jan 6;14(1):8. doi: 10.1038/s41419-022-05513-1. Cell Death Dis. 2023. PMID: 36609474 Free PMC article.
Abnormal activities of distal cis-regulatory elements (CREs) contribute to the initiation and progression of cancer. Gain of super-enhancer (SE), a highly active distal CRE, is essential for the activation of key oncogenes in various cancers. ...Functionally, MEC …
Abnormal activities of distal cis-regulatory elements (CREs) contribute to the initiation and progression of cancer. Gain of super-en …
Predicting master transcription factors from pan-cancer expression data.
Reddy J, Fonseca MAS, Corona RI, Nameki R, Segato Dezem F, Klein IA, Chang H, Chaves-Moreira D, Afeyan LK, Malta TM, Lin X, Abbasi F, Font-Tello A, Sabedot T, Cejas P, Rodríguez-Malavé N, Seo JH, Lin DC, Matulonis U, Karlan BY, Gayther SA, Pasaniuc B, Gusev A, Noushmehr H, Long H, Freedman ML, Drapkin R, Young RA, Abraham BJ, Lawrenson K. Reddy J, et al. Sci Adv. 2021 Nov 26;7(48):eabf6123. doi: 10.1126/sciadv.abf6123. Epub 2021 Nov 24. Sci Adv. 2021. PMID: 34818047 Free PMC article.
Current approaches to identifying MTFs rely on ChIP-seq data, which is unavailable for many cancers. We developed the CaCTS (Cancer Core Transcription factor Specificity) algorithm to prioritize candidate MTFs using pan-cancer RNA sequencing data. CaCTS ident …
Current approaches to identifying MTFs rely on ChIP-seq data, which is unavailable for many cancers. We developed the CaCTS (Cance …
Expanded phenotypic and hematologic abnormalities beyond bone marrow failure in MECOM-associated syndromes.
Lozano Chinga MM, Bertuch AA, Afify Z, Dollerschell K, Hsu JI, John TD, Rao ES, Rowe RG, Sankaran VG, Shimamura A, Williams DA, Nakano TA. Lozano Chinga MM, et al. Am J Med Genet A. 2023 Jul;191(7):1826-1835. doi: 10.1002/ajmg.a.63208. Epub 2023 Apr 17. Am J Med Genet A. 2023. PMID: 37067177
The MECOM gene encodes multiple protein isoforms that are essential for hematopoietic stem cell self-renewal and maintenance. ...A centralized international publicly accessible database to share annotated MECOM variants would advance their clinical interpretation an …
The MECOM gene encodes multiple protein isoforms that are essential for hematopoietic stem cell self-renewal and maintenance. ...A ce …
MECOM: A Very Interesting Gene Involved also in Lymphoid Malignancies.
Liu K, Tirado CA. Liu K, et al. J Assoc Genet Technol. 2019;45(3):109-114. J Assoc Genet Technol. 2019. PMID: 31554743
A review of the literature reveals four confirmed cases of MECOM cytogenetic abnormalities in lymphoid disorders, each of which could potentially implicate MECOM in the development or transformation of lymphoid disease. ...A query of the Mitelman Database of Chromos …
A review of the literature reveals four confirmed cases of MECOM cytogenetic abnormalities in lymphoid disorders, each of which could …
EVI1 drives leukemogenesis through aberrant ERG activation.
Schmoellerl J, Barbosa IAM, Minnich M, Andersch F, Smeenk L, Havermans M, Eder T, Neumann T, Jude J, Fellner M, Ebert A, Steininger M, Delwel R, Grebien F, Zuber J. Schmoellerl J, et al. Blood. 2023 Feb 2;141(5):453-466. doi: 10.1182/blood.2022016592. Blood. 2023. PMID: 36095844 Free article.
Chromosomal rearrangements involving the MDS1 and EVI1 complex locus (MECOM) on chromosome 3q26 define an aggressive subtype of acute myeloid leukemia (AML) that is associated with chemotherapy resistance and dismal prognosis. ...
Chromosomal rearrangements involving the MDS1 and EVI1 complex locus (MECOM) on chromosome 3q26 define an aggressive subtype of acute …
504 results