Enhanced T cell effector activity by targeting the Mediator kinase module.
Freitas KA, Belk JA, Sotillo E, Quinn PJ, Ramello MC, Malipatlolla M, Daniel B, Sandor K, Klysz D, Bjelajac J, Xu P, Burdsall KA, Tieu V, Duong VT, Donovan MG, Weber EW, Chang HY, Majzner RG, Espinosa JM, Satpathy AT, Mackall CL.
Freitas KA, et al.
Science. 2022 Nov 11;378(6620):eabn5647. doi: 10.1126/science.abn5647. Epub 2022 Nov 11.
Science. 2022.
PMID: 36356142
Free PMC article.
T cells are the major arm of the immune system responsible for controlling and regressing cancers. To identify genes limiting T cell function, we conducted genome-wide CRISPR knockout screens in human chimeric antigen receptor (CAR) T cells. Top hits were MED12 and …
T cells are the major arm of the immune system responsible for controlling and regressing cancers. To identify genes limiting T cell …