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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2005 1
2011 3
2012 15
2013 27
2014 29
2015 34
2016 35
2017 41
2018 56
2019 39
2020 37
2021 37
2022 44
2023 34
2024 17

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383 results

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Page 1
Genome-scale CRISPR-Cas9 knockout screening in human cells.
Shalem O, Sanjana NE, Hartenian E, Shi X, Scott DA, Mikkelson T, Heckl D, Ebert BL, Root DE, Doench JG, Zhang F. Shalem O, et al. Science. 2014 Jan 3;343(6166):84-87. doi: 10.1126/science.1247005. Epub 2013 Dec 12. Science. 2014. PMID: 24336571 Free PMC article.
First, we used the GeCKO library to identify genes essential for cell viability in cancer and pluripotent stem cells. Next, in a melanoma model, we screened for genes whose loss is involved in resistance to vemurafenib, a therapeutic RAF inhibitor. Our highest-ranking cand …
First, we used the GeCKO library to identify genes essential for cell viability in cancer and pluripotent stem cells. Next, in a mela …
Multi-layered prevention and treatment of chronic inflammation, organ fibrosis and cancer associated with canonical WNT/beta-catenin signaling activation (Review).
Katoh M. Katoh M. Int J Mol Med. 2018 Aug;42(2):713-725. doi: 10.3892/ijmm.2018.3689. Epub 2018 May 17. Int J Mol Med. 2018. PMID: 29786110 Free PMC article. Review.
beta-catenin/CTNNB1 is an intracellular scaffold protein that interacts with adhesion molecules (E-cadherin/CDH1, N-cadherin/CDH2, VE-cadherin/CDH5 and alpha-catenins), transmembrane-type mucins (MUC1/CD227 and MUC16/CA125), signaling regulators (APC, AXIN1, AXIN2 and NHERF1/EBP5 …
beta-catenin/CTNNB1 is an intracellular scaffold protein that interacts with adhesion molecules (E-cadherin/CDH1, N-cadherin/CDH2, VE-cadher …
MED12 and BRD4 cooperate to sustain cancer growth upon loss of mediator kinase.
Sooraj D, Sun C, Doan A, Garama DJ, Dannappel MV, Zhu D, Chua HK, Mahara S, Wan Hassan WA, Tay YK, Guanizo A, Croagh D, Prodanovic Z, Gough DJ, Wan C, Firestein R. Sooraj D, et al. Mol Cell. 2022 Jan 6;82(1):123-139.e7. doi: 10.1016/j.molcel.2021.11.015. Epub 2021 Dec 14. Mol Cell. 2022. PMID: 34910943 Free article.
Mediator kinases (CDK8/19) are transcriptional regulators broadly implicated in cancer. Despite their central role in fine-tuning gene-expression programs, we find complete loss of CDK8/19 is tolerated in colorectal cancer (CRC) cells. ...Concurrently, loss of Media …
Mediator kinases (CDK8/19) are transcriptional regulators broadly implicated in cancer. Despite their central role in fine-tuning gen …
Enhanced T cell effector activity by targeting the Mediator kinase module.
Freitas KA, Belk JA, Sotillo E, Quinn PJ, Ramello MC, Malipatlolla M, Daniel B, Sandor K, Klysz D, Bjelajac J, Xu P, Burdsall KA, Tieu V, Duong VT, Donovan MG, Weber EW, Chang HY, Majzner RG, Espinosa JM, Satpathy AT, Mackall CL. Freitas KA, et al. Science. 2022 Nov 11;378(6620):eabn5647. doi: 10.1126/science.abn5647. Epub 2022 Nov 11. Science. 2022. PMID: 36356142 Free PMC article.
T cells are the major arm of the immune system responsible for controlling and regressing cancers. To identify genes limiting T cell function, we conducted genome-wide CRISPR knockout screens in human chimeric antigen receptor (CAR) T cells. Top hits were MED12 and …
T cells are the major arm of the immune system responsible for controlling and regressing cancers. To identify genes limiting T cell …
MED12 mutation as a potential predictive biomarker for immune checkpoint inhibitors in pan-cancer.
Zhou Y, Tan Y, Zhang Q, Duan Q, Chen J. Zhou Y, et al. Eur J Med Res. 2022 Oct 29;27(1):225. doi: 10.1186/s40001-022-00856-z. Eur J Med Res. 2022. PMID: 36309740 Free PMC article.
In this study, clinical and whole-exome sequencing (WES) data from published studies were merged as a WES cohort to explore the association between MED12 mutation (MED12-Mut) and ICIs efficiency across cancers. Then, Memorial Sloan Kettering Cancer Cen …
In this study, clinical and whole-exome sequencing (WES) data from published studies were merged as a WES cohort to explore the association …
Fibroepithelial tumours of the breast-a review.
Lerwill MF, Lee AHS, Tan PH. Lerwill MF, et al. Virchows Arch. 2022 Jan;480(1):45-63. doi: 10.1007/s00428-021-03175-6. Epub 2021 Sep 10. Virchows Arch. 2022. PMID: 34505197 Review.
Fibroepithelial tumours of the breast are biphasic neoplasms composed of both epithelial and stromal elements, including the common fibroadenoma and the infrequent phyllodes tumour. ...Stromal mitotic activity can be increased in fibroadenomas in the young and pregnant pat …
Fibroepithelial tumours of the breast are biphasic neoplasms composed of both epithelial and stromal elements, including the common f …
Exosomal transfer of miR-548aq-3p confers cisplatin resistance via MED12 downregulation in epithelial ovarian cancer.
Shi Y, Zou Y, Guo Y, Liu Y, Wang Q. Shi Y, et al. Am J Cancer Res. 2023 May 15;13(5):1999-2012. eCollection 2023. Am J Cancer Res. 2023. PMID: 37293147 Free PMC article.
The RNA polymerase II mediator complex subunit 12 (MED12) is an important factor for chemotherapy sensitivity. We explored the roles of exosomal transfer of carcinogenic microRNAs (miRNAs) in MED12 regulation and cisplatin resistance of ovarian cancer cells. …
The RNA polymerase II mediator complex subunit 12 (MED12) is an important factor for chemotherapy sensitivity. We explored the roles …
MED12 mutation activates the tryptophan/kynurenine/AHR pathway to promote growth of uterine leiomyomas.
Zuberi A, Huang Y, Dotts AJ, Wei H, Coon JS 5th, Liu S, Iizuka T, Wu O, Sotos O, Saini P, Chakravarti D, Boyer TG, Dai Y, Bulun SE, Yin P. Zuberi A, et al. JCI Insight. 2023 Sep 22;8(18):e171305. doi: 10.1172/jci.insight.171305. JCI Insight. 2023. PMID: 37607000 Free PMC article.
Driver mutations in the transcriptional mediator complex subunit 12 (MED12) gene in uterine myometrial cells initiate 70% of leiomyomas that grow in a progesterone-dependent manner. We showed a distinct chromatin occupancy landscape of MED12 in mutant MED12 ( …
Driver mutations in the transcriptional mediator complex subunit 12 (MED12) gene in uterine myometrial cells initiate 70% of leiomyom …
Single-cell sequencing reveals novel cellular heterogeneity in uterine leiomyomas.
Goad J, Rudolph J, Zandigohar M, Tae M, Dai Y, Wei JJ, Bulun SE, Chakravarti D, Rajkovic A. Goad J, et al. Hum Reprod. 2022 Sep 30;37(10):2334-2349. doi: 10.1093/humrep/deac183. Hum Reprod. 2022. PMID: 36001050 Free PMC article.
PARTICIPANTS/MATERIALS, SETTING, METHODS: We collected five MED12-variant positive leiomyomas and five myometrium samples from a total of eight patients. ...Variant analysis at the single-cell level revealed the presence of both MED12 variants as well as the wild-ty …
PARTICIPANTS/MATERIALS, SETTING, METHODS: We collected five MED12-variant positive leiomyomas and five myometrium samples from a tota …
MED12 is recurrently mutated in Middle Eastern colorectal cancer.
Siraj AK, Masoodi T, Bu R, Pratheeshkumar P, Al-Sanea N, Ashari LH, Abduljabbar A, Alhomoud S, Al-Dayel F, Alkuraya FS, Al-Kuraya KS. Siraj AK, et al. Gut. 2018 Apr;67(4):663-671. doi: 10.1136/gutjnl-2016-313334. Epub 2017 Feb 9. Gut. 2018. PMID: 28183795 Free PMC article.
OBJECTIVE: Colorectal cancer (CRC) is a common cancer and a leading cause of cancer deaths. ...Importantly, these correlations were replicated when MED12 expression was experimentally manipulated. CONCLUSIONS: Our data expand the recently described rol …
OBJECTIVE: Colorectal cancer (CRC) is a common cancer and a leading cause of cancer deaths. ...Importantly, these corre …
383 results