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Year Number of Results
1999 1
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38 results

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Page 1
LINC00921 reduces lung cancer radiosensitivity by destabilizing NUDT21 and driving aberrant MED23 alternative polyadenylation.
Zhang N, Liu X, Huang L, Zeng J, Ma C, Han L, Li W, Yu J, Yang M. Zhang N, et al. Cell Rep. 2023 Dec 26;42(12):113479. doi: 10.1016/j.celrep.2023.113479. Epub 2023 Nov 24. Cell Rep. 2023. PMID: 37999979 Free article.
Alternative polyadenylation (APA) plays a major role in controlling transcriptome diversity and therapeutic resistance of cancers. However, long non-coding RNAs (lncRNAs) involved in pathological APA remain poorly defined. ...LINC00921-induced destabilization of NUDT21 pro …
Alternative polyadenylation (APA) plays a major role in controlling transcriptome diversity and therapeutic resistance of cancers. Ho …
MED23 in endocrinotherapy for breast cancer.
Lin B, Zhang L, Li D, Sun H. Lin B, et al. Oncol Lett. 2017 Jun;13(6):4679-4684. doi: 10.3892/ol.2017.6036. Epub 2017 Apr 13. Oncol Lett. 2017. PMID: 28588722 Free PMC article.
We also evaluated the endocrinotherapy and prevention method for breast cancer. Breast cancer cell strains were established that can continuously express MED23, as well as inducible MED23-shRNA expression plasmids. ...As a potential molecular therapeut …
We also evaluated the endocrinotherapy and prevention method for breast cancer. Breast cancer cell strains were established th …
Upregulation of mediator MED23 in non-small-cell lung cancer promotes the growth, migration, and metastasis of cancer cells.
Shi J, Liu H, Yao F, Zhong C, Zhao H. Shi J, et al. Tumour Biol. 2014 Dec;35(12):12005-13. doi: 10.1007/s13277-014-2499-3. Epub 2014 Oct 2. Tumour Biol. 2014. PMID: 25273169 Free article.
Mechanistically, MED23 was found to interact with beta-catenin and activate beta-catenin/TCF signaling. Our study demonstrated that MED23 played an oncogenic role in the progression of NSCLC and that MED23 might be a promising target for the treatment of NSCL …
Mechanistically, MED23 was found to interact with beta-catenin and activate beta-catenin/TCF signaling. Our study demonstrated that …
Selective requirement for Mediator MED23 in Ras-active lung cancer.
Yang X, Zhao M, Xia M, Liu Y, Yan J, Ji H, Wang G. Yang X, et al. Proc Natl Acad Sci U S A. 2012 Oct 9;109(41):E2813-22. doi: 10.1073/pnas.1204311109. Epub 2012 Sep 17. Proc Natl Acad Sci U S A. 2012. PMID: 22988093 Free PMC article.
By screening a large panel of human lung cancer cell lines with or without a Ras mutation, we found that Med23 RNAi specifically inhibits the proliferation and tumorigenicity of lung cancer cells with hyperactive Ras activity. ...Remarkably, lower Med23 …
By screening a large panel of human lung cancer cell lines with or without a Ras mutation, we found that Med23 RNAi specifical …
Med23 deficiency reprograms the tumor microenvironment to promote lung tumorigenesis.
Fu X, Liu S, Cao D, Li C, Ji H, Wang G. Fu X, et al. Br J Cancer. 2024 Mar;130(5):716-727. doi: 10.1038/s41416-023-02556-9. Epub 2024 Jan 9. Br J Cancer. 2024. PMID: 38195889 Free PMC article.
BACKGROUND: Lung cancer is the leading cause of cancer-related death worldwide. We previously found that Mediator complex subunit 23 (MED23) is important for the tumourigenicity of lung cancer cells with hyperactive Ras activity in vitro, although the …
BACKGROUND: Lung cancer is the leading cause of cancer-related death worldwide. We previously found that Mediator complex subu …
Med23 supports angiogenesis and maintains vascular integrity through negative regulation of angiopoietin2 expression.
Yang Y, Xiao Q, Yin J, Li C, Yu D, He Y, Yang Z, Wang G. Yang Y, et al. Commun Biol. 2022 Apr 19;5(1):374. doi: 10.1038/s42003-022-03332-w. Commun Biol. 2022. PMID: 35440711 Free PMC article.
Here, we dissected the role of the Mediator subunit Med23 in mouse cardiovascular development. Endothelial-specific Med23 deletion caused embryonic lethality before embryonic day 13.5 (E13.5). ...Knocking down Med23 in human umbilical vein endothelial cells ( …
Here, we dissected the role of the Mediator subunit Med23 in mouse cardiovascular development. Endothelial-specific Med23 dele …
MED23 depletion induces premature senescence in NSCLC cells by interacting with BCLAF1 and then suppressing NUPR1 expression.
Li Y, Sun Y, Jia B, Ma Z, Zhou R. Li Y, et al. Biochem Biophys Res Commun. 2024 Nov 19;734:150754. doi: 10.1016/j.bbrc.2024.150754. Epub 2024 Oct 2. Biochem Biophys Res Commun. 2024. PMID: 39366174
Lung cancer is the leading cause of cancer death worldwide. 85 % of lung cancers are categorized by their histological types as a non-small cell lung cancer (NSCLC) subtype. While the MED23 subunit of the mediator complex has been implicated in …
Lung cancer is the leading cause of cancer death worldwide. 85 % of lung cancers are categorized by their histological …
Downregulation of MED23 promoted the tumorigenecity of esophageal squamous cell carcinoma.
Shi J, Han Q, Zhao H, Zhong C, Yao F. Shi J, et al. Mol Carcinog. 2014 Oct;53(10):833-40. doi: 10.1002/mc.22041. Epub 2013 Apr 27. Mol Carcinog. 2014. PMID: 23625751
However, the function of MED23 in ESCC remains unknown. Here, we found that the expression of MED23 was downregulated in the clinical ESCC samples and the expression of MED23 reversely correlated with tumor size and clinical stage. ...Taken together, our stud …
However, the function of MED23 in ESCC remains unknown. Here, we found that the expression of MED23 was downregulated in the c …
Mediator MED23 Links Pigmentation and DNA Repair through the Transcription Factor MITF.
Xia M, Chen K, Yao X, Xu Y, Yao J, Yan J, Shao Z, Wang G. Xia M, et al. Cell Rep. 2017 Aug 22;20(8):1794-1804. doi: 10.1016/j.celrep.2017.07.056. Cell Rep. 2017. PMID: 28834744 Free article.
Little is known about the role of the transcriptional cofactor Mediator complex in DNA repair and pigmentation. Here, we demonstrate that Mediator MED23 plays an important role in coupling UV-induced DNA repair to pigmentation. The loss of Med23 specifically impairs …
Little is known about the role of the transcriptional cofactor Mediator complex in DNA repair and pigmentation. Here, we demonstrate that Me …
YEATS domain-containing protein GAS41 regulates nuclear shape by working in concert with BRD2 and the mediator complex in colorectal cancer.
Wang Z, Zhao N, Zhang S, Wang D, Wang S, Liu N. Wang Z, et al. Pharmacol Res. 2024 Aug;206:107283. doi: 10.1016/j.phrs.2024.107283. Epub 2024 Jul 2. Pharmacol Res. 2024. PMID: 38964523 Free article.
The maintenance of nuclear shape is essential for cellular homeostasis and disruptions in this process have been linked to various pathological conditions, including cancer, laminopathies, and aging. Despite the significance of nuclear shape, the precise molecular mechanis …
The maintenance of nuclear shape is essential for cellular homeostasis and disruptions in this process have been linked to various pathologi …
38 results