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1999 1
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2012 3
2013 4
2014 3
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2017 2
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Page 1
MED23 in endocrinotherapy for breast cancer.
Lin B, Zhang L, Li D, Sun H. Lin B, et al. Oncol Lett. 2017 Jun;13(6):4679-4684. doi: 10.3892/ol.2017.6036. Epub 2017 Apr 13. Oncol Lett. 2017. PMID: 28588722 Free PMC article.
We also evaluated the endocrinotherapy and prevention method for breast cancer. Breast cancer cell strains were established that can continuously express MED23, as well as inducible MED23-shRNA expression plasmids. ...As a potential molecular therapeut …
We also evaluated the endocrinotherapy and prevention method for breast cancer. Breast cancer cell strains were established th …
LINC00921 reduces lung cancer radiosensitivity by destabilizing NUDT21 and driving aberrant MED23 alternative polyadenylation.
Zhang N, Liu X, Huang L, Zeng J, Ma C, Han L, Li W, Yu J, Yang M. Zhang N, et al. Cell Rep. 2023 Dec 26;42(12):113479. doi: 10.1016/j.celrep.2023.113479. Epub 2023 Nov 24. Cell Rep. 2023. PMID: 37999979 Free article.
Alternative polyadenylation (APA) plays a major role in controlling transcriptome diversity and therapeutic resistance of cancers. However, long non-coding RNAs (lncRNAs) involved in pathological APA remain poorly defined. ...LINC00921-induced destabilization of NUDT21 pro …
Alternative polyadenylation (APA) plays a major role in controlling transcriptome diversity and therapeutic resistance of cancers. Ho …
Med23 deficiency reprograms the tumor microenvironment to promote lung tumorigenesis.
Fu X, Liu S, Cao D, Li C, Ji H, Wang G. Fu X, et al. Br J Cancer. 2024 Mar;130(5):716-727. doi: 10.1038/s41416-023-02556-9. Epub 2024 Jan 9. Br J Cancer. 2024. PMID: 38195889 Free PMC article.
BACKGROUND: Lung cancer is the leading cause of cancer-related death worldwide. We previously found that Mediator complex subunit 23 (MED23) is important for the tumourigenicity of lung cancer cells with hyperactive Ras activity in vitro, although the …
BACKGROUND: Lung cancer is the leading cause of cancer-related death worldwide. We previously found that Mediator complex subu …
Selective requirement for Mediator MED23 in Ras-active lung cancer.
Yang X, Zhao M, Xia M, Liu Y, Yan J, Ji H, Wang G. Yang X, et al. Proc Natl Acad Sci U S A. 2012 Oct 9;109(41):E2813-22. doi: 10.1073/pnas.1204311109. Epub 2012 Sep 17. Proc Natl Acad Sci U S A. 2012. PMID: 22988093 Free PMC article.
By screening a large panel of human lung cancer cell lines with or without a Ras mutation, we found that Med23 RNAi specifically inhibits the proliferation and tumorigenicity of lung cancer cells with hyperactive Ras activity. ...Remarkably, lower Med23 …
By screening a large panel of human lung cancer cell lines with or without a Ras mutation, we found that Med23 RNAi specifical …
Upregulation of mediator MED23 in non-small-cell lung cancer promotes the growth, migration, and metastasis of cancer cells.
Shi J, Liu H, Yao F, Zhong C, Zhao H. Shi J, et al. Tumour Biol. 2014 Dec;35(12):12005-13. doi: 10.1007/s13277-014-2499-3. Epub 2014 Oct 2. Tumour Biol. 2014. PMID: 25273169
Mechanistically, MED23 was found to interact with beta-catenin and activate beta-catenin/TCF signaling. Our study demonstrated that MED23 played an oncogenic role in the progression of NSCLC and that MED23 might be a promising target for the treatment of NSCL …
Mechanistically, MED23 was found to interact with beta-catenin and activate beta-catenin/TCF signaling. Our study demonstrated that …
Downregulation of MED23 promoted the tumorigenecity of esophageal squamous cell carcinoma.
Shi J, Han Q, Zhao H, Zhong C, Yao F. Shi J, et al. Mol Carcinog. 2014 Oct;53(10):833-40. doi: 10.1002/mc.22041. Epub 2013 Apr 27. Mol Carcinog. 2014. PMID: 23625751
However, the function of MED23 in ESCC remains unknown. Here, we found that the expression of MED23 was downregulated in the clinical ESCC samples and the expression of MED23 reversely correlated with tumor size and clinical stage. ...Taken together, our stud …
However, the function of MED23 in ESCC remains unknown. Here, we found that the expression of MED23 was downregulated in the c …
Med23 supports angiogenesis and maintains vascular integrity through negative regulation of angiopoietin2 expression.
Yang Y, Xiao Q, Yin J, Li C, Yu D, He Y, Yang Z, Wang G. Yang Y, et al. Commun Biol. 2022 Apr 19;5(1):374. doi: 10.1038/s42003-022-03332-w. Commun Biol. 2022. PMID: 35440711 Free PMC article.
The mutant embryos exhibited intracranial hemorrhage and diminished angiogenesis with dilated blood vessels in the head region, where the expression of Med23 was abundant at E10.5. Med23 deficiency impaired vasculogenesis in the head region and impeded retinal angio …
The mutant embryos exhibited intracranial hemorrhage and diminished angiogenesis with dilated blood vessels in the head region, where the ex …
Integration of radiogenomic features for early prediction of pathological complete response in patients with triple-negative breast cancer and identification of potential therapeutic targets.
Zhang Y, You C, Pei Y, Yang F, Li D, Jiang YZ, Shao Z. Zhang Y, et al. J Transl Med. 2022 Jun 7;20(1):256. doi: 10.1186/s12967-022-03452-1. J Transl Med. 2022. PMID: 35672824 Free PMC article.

The expression levels of gamma-H2A.X, p-ATM and p-CHK2 in MED23 p.P394H cells were significantly lower than those in wild type cells (p < 0.01). In the HR repair system, the GFP positivity rate of MED23 p.P394H cells was higher than that in wild-type cells (p &lt

…
The expression levels of gamma-H2A.X, p-ATM and p-CHK2 in MED23 p.P394H cells were significantly lower than those in wild type cells …
Mediator MED23 Links Pigmentation and DNA Repair through the Transcription Factor MITF.
Xia M, Chen K, Yao X, Xu Y, Yao J, Yan J, Shao Z, Wang G. Xia M, et al. Cell Rep. 2017 Aug 22;20(8):1794-1804. doi: 10.1016/j.celrep.2017.07.056. Cell Rep. 2017. PMID: 28834744 Free article.
The loss of Med23 specifically impairs the pigmentation process in melanocyte-lineage cells and in zebrafish. ...Collectively, the Mediator MED23/MITF axis connects DNA repair to pigmentation, thus providing molecular insights into the DNA damage response and skin-r …
The loss of Med23 specifically impairs the pigmentation process in melanocyte-lineage cells and in zebrafish. ...Collectively, the Me …
Interrupting specific hydrogen bonds between ELF3 and MED23 as an alternative drug resistance-free strategy for HER2-overexpressing cancers.
Hwang SY, Park S, Jo H, Hee Seo S, Jeon KH, Kim S, Jung AR, Song C, Ahn M, Yeon Kwak S, Lee HJ, Uesugi M, Na Y, Kwon Y. Hwang SY, et al. J Adv Res. 2023 May;47:173-187. doi: 10.1016/j.jare.2022.08.003. Epub 2022 Aug 10. J Adv Res. 2023. PMID: 35963541 Free PMC article.
RESULTS: ELF3-MED23 PPI was found to be specifically dependent on H-bondings between D400, H449 of MED23 and W138, I140 of ELF3 for upregulating HER2 gene transcription. Employing YK1, we confirmed that interruption on these H-bondings significantly attenuated the H …
RESULTS: ELF3-MED23 PPI was found to be specifically dependent on H-bondings between D400, H449 of MED23 and W138, I140 of ELF …
35 results