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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1993 1
1994 2
1995 1
1996 1
1997 1
1998 1
2000 2
2001 6
2005 2
2006 2
2007 5
2008 8
2009 6
2010 5
2011 10
2012 10
2013 11
2014 18
2015 18
2016 17
2017 11
2018 20
2019 15
2020 23
2021 25
2022 34
2023 22
2024 5

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237 results

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Page 1
Molecular Features of Cancer-associated Fibroblast Subtypes and their Implication on Cancer Pathogenesis, Prognosis, and Immunotherapy Resistance.
Galbo PM Jr, Zang X, Zheng D. Galbo PM Jr, et al. Clin Cancer Res. 2021 May 1;27(9):2636-2647. doi: 10.1158/1078-0432.CCR-20-4226. Epub 2021 Feb 23. Clin Cancer Res. 2021. PMID: 33622705 Free PMC article.
RESULTS: We identified six CAF subtypes (pan-CAF) shared across cancer types and uncovered the molecular characteristics and genetic pathways distinguishing them. ...CONCLUSIONS: Our study identifies the molecular characteristics of CAF subtypes shared across several ca …
RESULTS: We identified six CAF subtypes (pan-CAF) shared across cancer types and uncovered the molecular characteristics and genetic …
MEF2C silencing downregulates NF2 and E-cadherin and enhances Erastin-induced ferroptosis in meningioma.
Bao Z, Hua L, Ye Y, Wang D, Li C, Xie Q, Wakimoto H, Gong Y, Ji J. Bao Z, et al. Neuro Oncol. 2021 Dec 1;23(12):2014-2027. doi: 10.1093/neuonc/noab114. Neuro Oncol. 2021. PMID: 33984142 Free PMC article.
MEF2C silencing enhanced Erastin-induced ferroptotic meningioma cell death and lipid peroxidation levels in vitro, which was limited by forced expression of MEF2C targets, NF2 and E-cadherin. ...MEF2C could be a new molecular target in ferroptosis-inducing th …
MEF2C silencing enhanced Erastin-induced ferroptotic meningioma cell death and lipid peroxidation levels in vitro, which was limited …
MEF2C-AS1 regulates its nearby gene MEF2C to mediate cervical cancer cell malignant phenotypes in vitro.
Guo Q, Zhang L, Zhao L, Pang X, Wang P, Sun H, Liu S. Guo Q, et al. Biochem Biophys Res Commun. 2022 Dec 3;632:48-54. doi: 10.1016/j.bbrc.2022.09.091. Epub 2022 Sep 27. Biochem Biophys Res Commun. 2022. PMID: 36198203
Cervical cancer (CC) is the second most common malignancy among women. GEPIA demonstrated that MEF2C-AS1 and its nearby gene MEF2C present downregulation in CC tissues. ...MEF2C-AS1 competitively bound with miR-20 b-5p to upregulate MEF2C in CC …
Cervical cancer (CC) is the second most common malignancy among women. GEPIA demonstrated that MEF2C-AS1 and its nearby gene …
T-Cell Acute Lymphoblastic Leukemia: Biomarkers and Their Clinical Usefulness.
Bardelli V, Arniani S, Pierini V, Di Giacomo D, Pierini T, Gorello P, Mecucci C, La Starza R. Bardelli V, et al. Genes (Basel). 2021 Jul 23;12(8):1118. doi: 10.3390/genes12081118. Genes (Basel). 2021. PMID: 34440292 Free PMC article. Review.
Hence, TAL and/or LMO deregulation is typical of T-ALL with a mature phenotype (sCD3 positive) that of TLX1, NKX2-1, or TLX3, of cortical T-ALL (CD1a positive); HOXA and MEF2C are instead over-expressed in subsets of Early T-cell Precursor (ETP; immature phenotype) and ear …
Hence, TAL and/or LMO deregulation is typical of T-ALL with a mature phenotype (sCD3 positive) that of TLX1, NKX2-1, or TLX3, of cortical T- …
MEF2C promotes gefitinib resistance in hepatic cancer cells through regulating MIG6 transcription.
Zhang H, Liu W, Wang Z, Meng L, Wang Y, Yan H, Li L. Zhang H, et al. Tumori. 2018 Jun;104(3):221-231. doi: 10.1177/0300891618765555. Epub 2018 Apr 11. Tumori. 2018. PMID: 29714661
RESULTS: Our results indicated that both MEF2C and MIG6 could be upregulated in gefitinib-resistant cancer tissues and cancer cell lines compared with gefitinib-sensitive ones. ...This effect increased the gefitinib-resistant ability of cancer cells. T …
RESULTS: Our results indicated that both MEF2C and MIG6 could be upregulated in gefitinib-resistant cancer tissues and canc …
Mutation of TP53 Confers Ferroptosis Resistance in Lung Cancer Through the FOXM1/MEF2C Axis.
Peng M, Hu Q, Wu Z, Wang B, Wang C, Yu F. Peng M, et al. Am J Pathol. 2023 Oct;193(10):1587-1602. doi: 10.1016/j.ajpath.2023.05.003. Epub 2023 May 25. Am J Pathol. 2023. PMID: 37236507
Mutations in TP53 may be associated with the malignant or indolent progression of ground glass nodules in early lung cancer, but whether ferroptosis may also be involved in determining this biological process has not yet been determined. ...This study provides new insights …
Mutations in TP53 may be associated with the malignant or indolent progression of ground glass nodules in early lung cancer, but whet …
MEF2c-Dependent Downregulation of Myocilin Mediates Cancer-Induced Muscle Wasting and Associates with Cachexia in Patients with Cancer.
Judge SM, Deyhle MR, Neyroud D, Nosacka RL, D'Lugos AC, Cameron ME, Vohra RS, Smuder AJ, Roberts BM, Callaway CS, Underwood PW, Chrzanowski SM, Batra A, Murphy ME, Heaven JD, Walter GA, Trevino JG, Judge AR. Judge SM, et al. Cancer Res. 2020 May 1;80(9):1861-1874. doi: 10.1158/0008-5472.CAN-19-1558. Epub 2020 Mar 4. Cancer Res. 2020. PMID: 32132110 Free PMC article.
Furthermore, we identified the myocyte enhancer factor 2 C (MEF2C) transcription factor as a key upstream activator of Myoc whose gain of function significantly deterred cancer-induced muscle wasting and dysfunction in a preclinical model of pancreatic ductal adenoc …
Furthermore, we identified the myocyte enhancer factor 2 C (MEF2C) transcription factor as a key upstream activator of Myoc whose gai …
Integrative Bioinformatics Analysis Reveals That miR-524-5p/MEF2C Regulates Bone Metastasis in Prostate Cancer and Breast Cancer.
Tian Q, Lu Y, Yan B, Wu C. Tian Q, et al. Comput Math Methods Med. 2022 Sep 10;2022:5211329. doi: 10.1155/2022/5211329. eCollection 2022. Comput Math Methods Med. 2022. PMID: 36128051 Free PMC article.
Bone metastases are highly prevalent in patients with advanced prostate cancer and breast cancer and have a serious impact on the survival time and quality of life of these patients. ...Meanwhile, miR-524-5p could target and inhibit the expression of MEF2C, w …
Bone metastases are highly prevalent in patients with advanced prostate cancer and breast cancer and have a serious impact on …
Emerging role of LINC00461 in cancer.
Zhang Q, Zhong C, Shen J, Chen S, Jia Y, Duan S. Zhang Q, et al. Biomed Pharmacother. 2022 Aug;152:113239. doi: 10.1016/j.biopha.2022.113239. Epub 2022 Jun 6. Biomed Pharmacother. 2022. PMID: 35679722 Free article. Review.
LINC00461 is located in the intergenic region between the protein-coding genes MEF2C and TMEM161B. LINC00461 upregulation was associated with the risk of 13 tumors and was strongly associated with clinicopathologic features and poor prognosis in 11 tumors. LINC00461 is inv …
LINC00461 is located in the intergenic region between the protein-coding genes MEF2C and TMEM161B. LINC00461 upregulation was associa …
MicroRNA-190b expression predicts a good prognosis and attenuates the malignant progression of pancreatic cancer by targeting MEF2C and TCF4.
Li Y, Wang Z, Zhao F, Zeng J, Yang X. Li Y, et al. Oncol Rep. 2022 Jan;47(1):12. doi: 10.3892/or.2021.8223. Epub 2021 Nov 15. Oncol Rep. 2022. PMID: 34779502 Free PMC article.
The aim of the present study was to examine the expression of miR-190b in pancreatic cancer cell lines and tissues and evaluate its effects on cancer progression. ...In addition, it was also found that miR-190b directly targeted myocyte enhancer factor 2C (MEF2C …
The aim of the present study was to examine the expression of miR-190b in pancreatic cancer cell lines and tissues and evaluate its e …
237 results